胶质

Objective To study the anti-neuroglioma effect of methyl-mercuric chloride by observing the morphological changes of apoptotic neuroglioma cells induced with MMC in rats with brain neuroglioma.

目的：通过观察氯化甲基汞诱导大鼠脑胶质瘤细胞凋亡的形态学改变，探讨MMC的抗脑胶质瘤作用。

Methods Experimental group were lavaged with MMC for 5 d and 10 mg/kg BW per day after the conduction of the athymic rat model of neuroglioma, control group was given with sodium chloride at the same dose.

制备裸鼠皮下U251胶质瘤模型，随机分为对照组和实验组，实验组裸鼠注射U251脑胶质瘤细胞1 w后，每天灌胃给予10 mg/kg体重MMC，连续5 d，对照组给予相同体积的生理盐水。

Oligodenderocyte and oligodendroglioma cells in vitro were able to secret beta-trace protein and explained why the concentration of β-tp in CSF was higher than that in serum, it was suggested that the level of β-tp released depended on both of cell member and type.

胶质细胞和人脑胶质瘤细胞能分泌β-tp，细胞分泌β-tp水平的高低由细胞类型及细胞的多寡决定。

Results There was significant negative correlation between the Nogo-A expression and the morphological change of tumor tissues according to immunohistochemistry. Western-blot analysis also indicated that the gray value of Nogo-A protein band in the oligodendroglioma group was significantly higher than that in the anaplastic oligodendroglioma group.

结果 免疫组织化学结果显示，Nogo-A免疫阳性染色的光密度值与肿瘤细胞核分裂、核异型比例呈明显的负相关，对蛋白印迹试验结果进行光密度分析也发现少突胶质细胞瘤中的Nogo-A蛋白条带灰度值明显高于间变型少突胶质细胞瘤中的灰度值。

To study levels of beta-trace protein in the cerebrospinal fluid with oligodendroglioma patients and in the mediums of incubated rat oligodenderocyte.

蒋雨平 ，蔡振林，任惠民目的：探索神经胶质细胞及人脑胶质瘤细胞是否能分泌β-tp。

The St. Jude team first determined that CSCs are located in ascular niches by identifying cells carrying a protein called Nestin that marks stem cells (Nestin+ cells) in four types of brain cancer remoed from patients: medulloblastoma, ependymoma,oligodendroglioma and glioblastoma.

圣犹达研究组研究了病人的四种脑肿瘤：成神经管细胞瘤、室管膜细胞瘤、少突神经胶质瘤和成胶质细胞瘤，通过鉴别名为Nestin的蛋白来识别肿瘤干细胞，第一个验证了肿瘤干细胞存在于血管性的微环境中。

It was demonstrated that the growth of glioma in rat can be inhibited by PCNA antisense oligonucleotides, the expression of PCNA target gene and prolification of glioma cells can be inhibited by PCNA antisense oligonucleotides.

PCNA反义寡核苷酸对胶质瘤的生长具有抑制作用，通过反义技术可抑制靶基因的表达，从而抑制胶质瘤细胞的增殖。

Methods:Thirty-seven glioma specimens were classified as astrocytoma(25 cases, including 7 fibrillary cases; 6 protoplasmic cases; 12 anaplasfic cases), and glioblastoma( 12 cases,including 4 GBM cases).

37例人脑胶质瘤标本按WHO分类标准(1990)分为：星形细胞瘤(25例，纤维型7例，原浆型6例，间变型12例)，胶质母细胞瘤(12例，包括GBM4例)。

RESULTS:Immunogold particles for IRE1 could be identified in RGCs of the retin...

IRE1在RGC与少突胶质细胞内胶体金标记颗粒分布部位距离ER管腔距离增加为特征，在钳夹0.5d内神经干少突胶质细胞以及视网膜RGC内均表现非常明显的距离增加。

It has been proved by previous studies that peripheral nerve injury can induce a series of changes of expression of some neural active material and their receptors either in the somata or in the terminals of the damaged primary afferent neurons and motoneurons. These changes may reflect a re-ordering of metabolic priorities so that the synthesis of trophic factors or growth-associated proteins augmented while that of neurotransmitter-related proteins decreased.

以往的研究表明，周围神经损伤能够引起受损神经元(包括初级传入神经元和运动神经元)的胞体或终末内某些神经活性物质及其受体的表达发生一系列变化，其中与神经生长和营养有关的物质常发生上调，而与神经传递有关的物质则发生下调；与此同时，受损神经元的周围常伴随发生胶质反应及神经胶质增生等变化。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。