胶原

Methods The rat models of heart failure were established by left anterior descending coronary artery deligation. After 6 w, 24 surviving rats were divided into sham,model and Ramipril groups at random,8 rats in each,and were treated with medicines by intragastric administration respectively. At 10 w, left ventricular enddiastolic pressure, left ventricular systolic pressure,+dp/dtmax anddp/ dtmaxof left ventricular pressure were measured.

结扎大鼠左冠状动脉前降支并饲养6 w的16只存活大鼠，随机分为模型组及雷米普利组，每组8只，另取8只大鼠为假手术组，连续灌胃给药4 w后测定大鼠血流动力学参数，ELISA方法检测血清及左心室非梗死区AngⅡ的含量，RTPCR 法测定左心室非梗死区心肌组织AT1R mRNA表达水平，Masson染色观察非梗死区心肌胶原的沉积。

The speed of collagen fiber depositation decrease with aging.

窦房结在衰老过程中胶原纤维的沉积速度减慢

Desmodium pulchellum has the effect on antihepatic fibrosis. The mechanism is possibly concerned that it can make liver cell immune against injure and deduce indirectly the forming of liver collagen protein.

排钱草具有抗肝纤维化作用，其机理可能与其能保护肝细胞免受损伤破坏，从而间接减少肝内胶原纤维形成有关。

A kind of intramolecular charge transfer compound——3 methoxy 4' N,N dimethylamino flavone derivateves was used to detect collagen association in aqueous solution.

利用一种分子内电荷转移化合物3-甲氧基-4'N，N-二甲氨基黄酮作为荧光探针，研究了胶原蛋白在水溶液中的聚集状态。

Disodium cromoglycate can inhibit slightly the proliferation and collagen synthesis of hypertrophic scar fibroblasts in vitro .

本实验浓度组的色甘酸钠在体外对瘢痕成纤维细胞的增殖和胶原合成抑制作用有限。

This may be done on a temporary basis with a dissolvable collagen plug, or permanently with a silicone plug.

这一程序可以暂时用可溶解的胶原质塞来完成，或者用永久性的硅树脂塞来完成。

Sinusoids may become less distensible with the formation of collagen within the space of Disse.

肝窦的扩张性可能会随着Disse间隙内胶原的形成而更行降低。

Hematoxylin and eosin, Alcian blue, Masson Trichrome, and Elastica Van Giesonstains were performed for each LF. Nine LF were collected and were used for biologic study of real time RT-PCR to quantitatively measure mRNA expression of Type I collagen and elastin in each LF.

每份标本用HE染色、Alcian蓝染色， Masson Trichrome染色以及Elastica Van Gieson染色。9份标本染色后收集，用实时定量PCR定量分析每份标本中I 型胶原纤维和弹力纤维的mRNA的表达。

Third, as suggested in the study of human cells, the ellagic acid reduced inflammatory response and MMP secretion due to protection from the degradation of collagen.

第三，与人类细胞试验结果一样，鞣花酸可以减轻炎症反应，减少MMP分泌，以此保护胶原蛋白不被降解。

Objective To study the relationship of endangium proliferation and the expression of metalloproteinases and tissue inhibitors of metalloproteinases after angioplasty of iliac artery in rabbits to investigate the probable mechanism of composite Danshen pill in prevention and treatment of restenosisMethods 30 white male rabbits of Japan （the average body weight was 25～30 kg）were randomly divided into 3 groups:normal control group,model group (intima destroyed by balloon and given hypercholesterol diet),CDP group (intima destroyed by balloon and given hypercholesterol diet plus drug CDP 150 mg/d),10 ones each groupResults The results of iliac artery angiogram and the analysis of pathology:there were lumens stenosis,thinner intima,smaller intima area,in CDP group compared with those in model group,and ratio of intima and tunica media thickness and area among each group (P＜001)Immunohistochemistry analysis:the MMP2,MMP9,TIMP1,TIMP2 in model group significantly increased than those in control group (P＜001)The CDP group had lower MMP2 and MMP9 expression,higher TIMP1 and TIMP2 expression,and increased MMP2/TIMP1,MMP9/TIMP2 than model group (P＜001)The thickening of vascular neointima and stenosis degree of vascular lumen were relevant to MMP2 and MMP9 (r=0896,P＜001)Conclusions MMP and TIMP play the very important role in the restenosis process of arteryCDP could inhibit the thickness of vascular neointima after balloon injury,the probable mechanism of which may be inhibiting collagen formation,smooth muscle immigration and decreasing hyperplasia of intima by interfering expression of MMPs and TIMPs

目的 研究兔髂动脉成形术后血管内膜增生和基质金属蛋白酶及其抑制物表达之间的关系，探讨复方丹参滴丸预防再狭窄的可能机制。方法健康成年二级雄性日本大耳白兔30只，平均体重25～30 kg。随机分为3组：正常对照组10只，模型组10只（球囊内膜剥脱加高胆固醇饮食），治疗组10只（球囊内膜剥脱加高胆固醇饮食以及复方丹参滴丸150 mg/d）。结果兔髂动脉造影、血管病理图像分析检测结果：①复方丹参滴丸组较模型组血管造影示管腔直径狭窄、内膜厚度减少、内膜面积减少、内膜厚度和中膜厚度比、面积比，各组之间有显著性差异(P＜001)。②免疫组化分析：模型组MMP2、MMP9、TIMP1、TIMP2表达均高于对照组（P＜001）；复方丹参滴丸组MMP2、MMP9的表达低于模型组，而TIMP1、TIMP2的表达高于模型组；TIMP1/MMP2、TIMP2/MMP9明显增加，差异有显著性（P＜001）。③内膜的增生以及管腔的狭窄程度与MMP2、MMP9有很好的相关性(r=0896，P＜001)。结论 MMP和TIMP在再狭窄形成中起重要作用；复方丹参滴丸能够明显抑制血管损伤后的内膜增生，可能的机制是通过影响金属蛋白酶MMP2、MMP9及其抑制物TIMP1、TIMP2的表达从而抑制胶原的生成、平滑肌的迁移、增生，而减少内膜的增生。

Plunder melds and run with this jewel!

掠夺melds和运行与此宝石！

My dream is to be a crazy growing tree and extend at the edge between the city and the forest.

此刻，也许正是在通往天国的路上，我体验着这白色的晕旋。