胶原

Methods Expression of MMP-8, collagen Ⅰ and collagen Ⅲ in fascia transversalis from the patiens of indirect inguinal hernias and non hernias was examined by immunohistochemical method.

采用免疫组织化学方法检测30例腹股沟斜疝患者及25例非病患者腹横筋膜中MMP-8、胶原Ⅰ、胶原Ⅲ的表达。

Materials and methods: The lung preparation of 6 SARS death patient (died in 9,14,20,29,33,38d) and 6 macaque model (killed in 7,12,14,14, 32, 35d)were objects. Pathological changes, collagen fibers, lattice fibers, elastic fibers, collagen I and III in lungs and fine structure changes were studied by routine H.E dyeing, trigeminy dyeing, trinitrophenol- sirius red staining and polarization microscope, electron microscope and image analysis. Expression of Vimentin、 TGFβ_1、 TNF α、 IL-1β and MMP-2 were detected by immunohistochemistry.Results:1. Pathological changes of SARS death patient.

材料与方法：以6例SARS死亡患者(分别于发病后9、14、20、29、33、38d死亡)和6只猕猴实验模型(分别于染毒后7、12、14、14、32、35d活杀取材)肺标本为对象，应用H.E染色、三联染色、苦味酸-天狼猩红-偏振光法、电镜和图像分析等技术，对比性观察SARS肺组织病理变化和纤维化的病理过程、胶原纤维、网状纤维和弹力纤维的变化特点、Ⅰ型与Ⅲ型胶原纤维的数量和分布规律，旨在探讨SARS肺纤维化的病变经历过程及特点；利用免疫组织化学和形态计量学技术检测SARS死亡患者肺脏的Vimentin、TGFβ_1、TNFα、IL-1β和MMP-2等与炎症反应和纤维化相关活性因子，探讨其发病机制。

The tripeptide it contains, under the penetration by transdermal enhancer, can rapidly combine with reducing sugar to effectively reduce the bond between collagen caused by the combination of reducing sugar and collagen, avoid protein denaturation which leads to impoverished skin, and remove the fine lines and wrinkles of skin.

添加三胜肽在透皮促进剂的渗透下迅速与还原糖结合，有效地减少还原糖与胶原蛋白的结合所造成胶原蛋白相互交结，避免蛋白质变性而使皮肤失去弹性，并可以驰缓组织，抚平皮肤上既有的细纹与皱纹。

Whereas osteoporosis is unassociated with bone pain, osteomalacia has been associated with isolated or generalized bone pain.39,40 The cause is thought to be hydration of the demineralized gelatin matrix beneath the periosteum; the hydrated matrix pushes outward on the periosteum, causing throbbing, aching pain.7 Osteomalacia can often be diagnosed by using moderate force to press the thumb on the sternum or anterior tibia, which can elicit bone pain.7,40 One study showed that 93% of persons 10 to 65 years of age who were admitted to a hospital emergency department with muscle aches and bone pain and who had a wide ariety of diagnoses, including fibromyalgia, chronic fatigue syndrome, and depression, were deficient in itamin D.41

然而，骨质疏松症与骨痛无关联，而软骨病则与局部性或全身性骨痛有关。其原因被认为是骨膜下已去矿质化的胶原基质上发生的水合反应，水合的胶原基质在骨膜上向外扩张，引起阵痛。软骨病可通过以拇指适度挤压胸骨和胫骨前方以引起骨痛感。一项研究显示10岁到65岁中有93%的人向医院急诊室承认有肌肉疼痛和骨痛症状，他们还有一些其他症状包括纤维肌痛、慢性疲劳综合征、抑郁等，该研究显示他们都缺乏维生素D。本人已认领该文第9、10两部分，48小时后若未提交译文，请其他战友自由认领。本人已认领该文11、12部分编译，48小时后若未提交译文，请其他战友自由认领。本人认领第十三部分，48小时内交稿请战友纠错！

Objective To explore the indication of treatment of lumbar disc herniation with collagenase Methods The surgical operations were made in 30 cases of the lumbar disc herniation treated with collagenase, all of them were uneffective.

目的进一步探讨胶原酶治疗腰椎间盘突出症的适应证。方法在2年中对30例用胶原酶治疗腰椎间盘突出症的患者因治疗无效，症状未改善，予以手术摘除术。

Excessive collagen degradation and depressed collagen synthesis ability lead to unhealing wound.

慢性皮肤溃疡创面内胶原合成能力降低和胶原分解过度，成为创面难愈合的重要原因。

Drug intervention groups received either daily inhalation of budesonide, ipratropine or heparin respectively, starting on the 8th day or TGF-β1 monoclonal antibody(TB21)0.5 mg twice (6th and 19th day) via the tail veinous injection.

其它各药物干预组于制作模型第8 d起分别雾化吸入布地奈德（布地奈德组，12只）、溴化异丙托品（溴化异丙托品组，12只）和肝素（肝素组，6只）溶液。4周后检测小支气管平滑肌及胶原厚度，用免疫组化法及原位杂交法观察各生长因子在支气管肺内的表达，用放免法检测血清和BALF中细胞外基质成分Ⅲ型前胶原、层粘连蛋白及透明质酸。

Expressive grads of type Ⅰ collagen mRNA were control group0.05 , but it did not come to the same thing in experimental group.

说明人AS时Ⅰ型胶原、NF-κB、VCAM-1、CD36蛋白及Ⅰ型胶原mRNA、NF-κBmRNA的表达明显增加。

As the collagen layer thickens, older collagen calcifies and older chondrocytes deteriorate.

随着胶原层变厚，原来的胶原钙和关节软骨细胞退化。

The results also indicate that collagen denaturalizes gradually with increasing temperature in the range (10℃-40℃).

实验结果表明随着温度的升高，在10℃-40℃范围内胶原的吸附量逐渐降低，在 40℃-45℃范围内锐减，40℃是本实验条件下胶原的变性温度。

And Pharaoh spoke to Joseph, saying, Your father and your brothers have come to you.

47：5 法老对约瑟说，你父亲和你弟兄们到你这里来了。

Additionally, the approximate flattening of surface strip using lines linking midpoints on perpendicular lines between geodesic curves and the unconditional extreme value method are discussed.

提出了用测地线方程、曲面上两点间短程线来计算膜结构曲面测地线的方法，同时，采用测地线间垂线的中点连线和用无约束极值法进行空间条状曲面近似展开的分析。