胶原

The palate bone defects can be repaired completely by GBR with collagen composite of human recombinant morpho...

1复合Hr -BMP胶原膜GBR具有确实有效的骨引导和骨诱导性，在骨缺损修复的早期阶段即可产生大量的新骨；2 复合Hr-BMP胶原膜植入后 4周内的成骨活动最活跃，胶原膜和复合Hr-BMP胶原膜在其降解吸收过程中，不干扰后续的成骨活动；3仍有必要构建具有适合的吸收降解性和一定力学强度的隔膜材料。

DESCRIPTION】the ingredients of the product comes from abyssopelagic fishes of special pure and clean sea areas, adopting Limited Enzymic Degraded Technology, a self-owned intellectual property, that is using compound bioenzyme preparations at a low temperature to extract active ingredients through a special low-temperature extraction process and specific sheared protein to ensure the bioactivity of Collagen.

本品原料来自纯净、无污染的特定海域中的深海鱼类，采用具有自主知识产权的限制性酶切制备多肽技术（Limited Enzymic Degraded Technology），在低温下使用复合生物酶制剂，通过特殊低温萃取工艺提取有效成分，通过特异性的剪切蛋白质，保证了胶原蛋白原有的生物活性，并将原分子量为30万左右的胶原蛋白分子降解成3500左右的胶原蛋白多肽（约含30个左右的氨基酸残基），其分子长度降至30—50nm，集中度达到99.5%以上，呈白色或淡黄色，无异味，无杂物，不添加任何激素和化学物质，没有任何毒副作用。

The result of Picric- sirius red polarized light method shows thatthe accrementition and reconstitution of mesenchymal fibers were markedly in experimental group compared with control group, especially in plantaris.Ⅰ-type collagen dominates in mesenchymal, IOD ratio ofⅠ/Ⅲchanged.

5天狼猩红-偏振光法提示在实验组骨骼肌间质纤维结缔组织明显增多尤其是在跖肌，以Ⅰ和Ⅲ型胶原增生为主，Ⅰ型胶原增生更为明显，Ⅰ型胶原与Ⅲ型胶原比值增高。

A method of capillary electrophoresis with tris (2,2′-bipyridyl) ruthenium electrochemiluminescence detection has been applied to the simultaneous determination of proline and hydroxyproline in human urine.

1引言胶原蛋白中常含有丰富的脯氨酸和羟脯氨酸，其中Hyp几乎为胶原蛋白所特有。在胶原蛋白代谢中，Pro通过羟基化形成Hyp，胶原蛋白降解释放的Hyp从尿中排泄[1]。

Results :①The MVs were formed by osteoblast of the secret type、dentinoblast and process;② There was a mature process of the MVs in the extracellular matrix.The appearance of the hydroxyapatite was a major mature feature;③ HAP formed initially in the MVs entered into collage matrix and eventually mineralized;④ The shifting sign of HAP from MVs to the surface of collage fibril was observed.

结果：①MVs是由分泌型成骨细胞、成牙本质细胞及其突起芽生进入胶原基质；②MVs在细胞外胶原基质中有一个逐渐成熟的过程，并以羟基磷灰石（hydroxyapatite，HAP）晶体的出现为其主要特征；③HAP在MVs内形成、增多，最终进入胶原基质并进一步沉积、钙化；④部分胶原原纤维表面沉积的HAP 晶体与MVs分泌的晶体有明显的移形迹象。

The objectives of the study were to investigate the characteristics and influencing factors of myocardial interstitial collagen of right ventricle in tetralogy of Fallot.Tissues of the infundibular septum from 22 patients with TOF were studied and 8 patients without cardiovascular disease and collagen system disease were used as control.Collagen were determined by biochemical methods.

为了解法洛四联症肥大右室心肌间质Ⅰ、Ⅲ型胶原改建的特点及其影响因素，用生化等方法定量分析了22例法洛四联症病人和8例非心血管及胶原系统疾病尸检者的右室心肌间质中的胶原含量和Ⅰ、Ⅲ型胶原比值，以及法洛四联症病人的血氧饱和度等影响因素。

Methods Samples of the infundibular septum from 22 patients with TOF and 8 patients without cardiovascular disease and collagen system disease as control were studied. Collagen was determined by biochemical methods, Pro α mRNA, Pro α mRNA levels were determined by dot blot hybridization.

用生化方法定量分析了22例法乐四联症患者和8例非心血管及胶原系统疾病尸检者的右室心肌间质中的胶原含量和Ⅰ、Ⅲ型胶原比值，以及用斑点杂交法测定法乐四联症患者右室心肌间质Ⅰ、Ⅲ型前胶原基因mRNA的表达。

A special delaminated expression was observed in the pericystic layer of hepatic hydatid cyst Collagen Ⅰ,Ⅲ and Ⅳ expression in the side of pericystic layer directed to the cyst of parasite(50 0%,37 5% and 40 0%) were lower than those in the side of pericyst...

靠近虫体侧纤维囊壁中，Ⅰ、Ⅲ和Ⅳ型胶原的表达阳性率分别为500%、375%和400%。靠近肝实质侧纤维囊壁中，Ⅰ、Ⅲ和Ⅳ型胶原的表达阳性率分别为875%、825%和850%。Ⅰ、Ⅲ、Ⅳ型胶原在两层中表达的差异均有显著意义(P01，P01，P01)。肝包虫囊肿周围人体纤维囊壁分层，Ⅰ、Ⅲ和Ⅳ型胶原与肝实质侧纤维囊壁的形成有密切关系。

Special staining methods, such as Masson and the Van Gieson staining were used to study the distribution of collogen fibers and elastic fibers. ResultsBy HE staining, the subepithelial connective tissues and vessels in the pterygium were more prominent than normal conjunctival tissues. An amorphous subepithelial superficial hyalinized zone and coarse eosinophilic granular materials were observed in the pterygia, but they were not found in normal conjunctival specimens. Coarse fibers were visible only in the deeper subepithelial connective tissues of pterygial samples. With Masson′s staining, the dense staining of collagen fibers was also more prominent in the pterygium than in the subepithelial connective tissues of normal conjunctiva. Abnormal collagen fibers were visible in the deeper sub-epithelial connective tissues of pterygial samples. With Van Gieson staining, abnormal collagen fibers were visible in the deeper subepithelial connective tissues. Dark coarse elastic fibers were found in the abnormal fibers only in the subepithelial deep connective tissues of pinguecula in the pterygia but not in the conjunctiva. With immunohistochemistry staining, MMP-3 was strong in the pterygial epithelium, moderate in fibroblast and absent from pterygial vascular walls. LN was strongly expressed in the blood vessel wall, moderately in the epithelial basement membrane and absent from the entire stroma.

结果HE染色：翼状胬肉组织上皮下基质中存在结缔组织的增生和血管形成；基质浅层存在一无定形物质透明区及粗糙的颗粒样嗜酸性物质，在翼状胬肉体部深层基质中存在粗糙的纤维组织；正常球结膜组织细胞排列整齐；基质为疏松结缔组织，胶原纤维平行排列，其间可见成纤维细胞，散在少量中性粒细胞、毛细血管；Masson染色：翼状胬肉浅层基质中存在致密的胶原纤维染色，深层基质中的胶原纤维存在变性样改变；VG染色：翼状胬肉组织深层基质中存在大量变性的胶原纤维，其间夹杂黑色的弹性纤维；免疫组化染色法：MMP-3在翼状胬肉上皮细胞中呈强表达，成纤维细胞中呈中等强度表达，血管内皮细胞中未见表达；LN在血管壁中呈强表达，在上皮细胞基底膜中呈中等强度表达，在整个基质中未见明显表达；col Ⅲ在整个翼状胬肉基质中呈强表达。

SP tested the vimentine expression around filling materials, from three days to two weeks after operation, the tinctorial intensity level around silicon gel was highe...

术后3～14天，硅凝胶周围波形蛋白表达量比注射用胶原蛋白高（P＜0.05），注射用胶原蛋白比HPG高（P＜0.05）；术后30～90天，注射用胶原蛋白周围波形蛋白表达量比硅凝胶高（P＜0.05），硅凝胶比HPG高（P＜0.05）。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。