胶原

Appraised the clinical effect of the flavone of rhizome drynania on Senile Osteoporosis, according to the dynamic observation on integrative scores of lumbodorsal pain and lumbodynia,"VAS section grading method" on lumbodynia,"Barthel index rating method" on ADL, detected BMD on anterior-posterior position lumbar2~4 vertebra body and proximate of femur including neck/ward/troch, and determined the index of bone transition including BGP/PINP/ICTP through the radioimmunity method before and after treated half a year, then contrast intragroup and selfgroup. Depending on the standard of curative effect, contrast the difference of curative effect between two groups.

采用随机对照的方法，分为治疗组36例，对照组34例，依据对腰背痛及腰痛综合评分进行动态观察；依据&疼痛VAS线段分级法&对腰背痛（静止痛、翻身痛、久坐痛、起身痛、弯腰痛、步行痛、睡眠痛、叩击痛、压痛）进行量化动态观察；依据&Barthel指数评定法&对老年性骨质疏松症日常生活活动能力进行观察；采用双能X线骨密度仪对腰椎(L2-L4)、股骨近端各部位：股骨颈、股骨三角区、股骨粗隆进行骨密度定量检测；应用放射免疫法对骨转换指标进行测定，骨形成指标：骨钙素、Ⅰ型前胶原氨基端前肽；骨吸收指标：Ⅰ型胶原交联羧基末端肽等，评价骨碎补总黄酮治疗老年性骨质疏松症的临床效果。

Methods 30 patients with trichloroethylene medicamentous dermatitis and 30 normal persons were selected as the observation group and the control group respectively; color Doppler was used to detect the spleen thickness and longitudinal length, spleen vein and artery diameters, the maximum blood velocity and blood flow of spleen vein and artery; RIA was applied to determine the serum levels of HA, LN, PCⅢ, CⅣ and CG; relevant analysis was made on the linear relationship between serum indices of hepatic fibrosis and spleen hemodynamics of the two groups.

选择30例三氯乙烯药疹样皮炎患者作为观察组，30例同时期健康体检者作为对照组，用彩色多普勒超声仪，检测脾脏厚度及长径、脾动静脉直径、脾动静脉血流量和脾静脉最大流速SPV(下标 x。用放射免疫法检测肝纤维化指标透明质酸、层粘连蛋白、Ⅲ型前胶原、Ⅳ型胶原和甘胆酸的水平，并对观察组与对照组的脾血流动力学参数与肝纤维化指标进行相关分析。

Bone marrow-derived mesenchymal stem cells are capable of chondrogenesis, making them a possible source of cells for injectable cartilage tissue engineering. There exist different ideas on the ability of mesenchymal stem cells's chondrogenesis in monolayer culture. Because of this, the effect of adult rabbit's bone marrow-derived mesenchymal stem cells chondrogenesis in monolayer culture was studied. The mesenchymal stem cells was isolated from adult rabbit's bone marrow and monolayer cultured. TGF-β1, Vit-C and Dexamethasone were used. Immunohistochemistry analyses and histological staining of H-E, Methylaniline blue and Alcian blue were performed to identify the expression of collagen type Ⅱ and cartilage associated matrix. The results showed that the induced cells expressed and produced collagen type Ⅱ and cartilage associated matrix. This suggests that the differentiation of adult rabbit's marrow-derived mesenchymal stem cells into chondrocyte in monolayer culture is feasible and may be induced by TGF-β1, Vit-C and Dexamethasone.

骨髓基质干细胞的软骨分化潜能使其可能成为可注射组织工程化软骨研究的种子细胞，为探讨体外培养的骨髓基质干细胞在平面诱导条件下软骨分化的可行性，我们进行下列实验：获取并体外平面培养成体兔骨髓基质干细胞，应用TGF-β〓、Vit-C和地塞米松对其软骨分化诱导，诱导后的骨髓基质干细胞行细胞爬片组织学和Ⅱ型胶原免疫组化，结果证实，诱导后骨髓基质干细胞可分泌Ⅱ型胶原，组织学染色可见类似于软骨细胞，由此证明体外培养的骨髓基质干细胞在平面诱导条件下可以软骨分化，其软骨诱导因子为TGF-β〓、Vit-C和地塞米松。

Image analysis system was used for semi-quantitive assay of TGF-βRⅠ and R Ⅱexpression, and microphotography was used to record the morphologic changes of culturedchondrocytes. The results are:1. TGF-〓 showed sequentially inhibitory and promotive effects on the proliferation of human articular chondrocytes of two week monolayer culture from one passage to eight passage.

本研究采用CellTiter 96〓单溶液细胞增殖分析试剂盒测定体外培养中的软骨细胞的增殖活细胞数量；免疫组化法测定软骨细胞TGF-βR Ⅰ、R Ⅱ，Ⅱ型胶原和S-100蛋白的定性表达；酶免分析法测定TGF-〓作用后的Ⅱ型胶原定量表达；通过图象分析仪，对TGF-βRⅠ、R Ⅱ的免疫组化染色结果进行半定量分析；本研究的实验结果如下：1。

3 Can partially prevent excess collagen deposition in pulmonary arteries, attenuate hypoxia and MCT-induced pulmonary hypertension and reduce the percentage of nonmuscular intra-acinar arteries.

但对缺氧性肺动脉高压肺动脉壁胶原的抑制以及逆转右室肥厚的作用弱于BAPN.3.764-3很可能通过逆转中膜平滑肌细胞表型的改变而抑制肺动脉壁胶原的过度沉积。4。

Chronic hypoxia and MCT-induced pulmonary hypertension are associated with excess collagen deposition in pulmonary arteries; meanwhile, the muscularization of nonmuscular intra-aeinar arteries also plays an important role in maintenance of pulmonary hypertension.

1。在慢性缺氧和MCT诱发的肺动脉高压进展过程中，肺动脉壁胶原沉积过度，泡内动脉结构发生改变，动脉中层厚化，非肌性动脉肌性化。2.764-3能部分抑制胶原的过度沉积，降低缺氧性及野百合碱性肺动脉高压，从而逆转泡内动脉的结构改变。

In this study the composites were applied to repair the rabbits'mandibular defects and implanted at the surface as onlay grafts that was fixed with dental implants. The ability of the composites repairing maxillofacial defects was evaluated with general observation, radiological and histological examination and compared with autogenous bone and coral.

本研究通过观察rhBMP-2、胶原、珊瑚复合骨修复兔下颌骨缺损，加高狗下颌骨骨面及与牙种植体结合，并与新鲜自体骨和珊瑚的修复作用比较，（1）应用复合骨修复兔下颌骨缺损，1、2、3个月取材，（2）将复合骨植于狗下颌骨体部颊侧骨膜下，采用钛种植体固定，1.5、3个月取材，通过体视及测量，X线片，组织学等观测指标，分析rhBMP-2、胶原、珊瑚复合骨修复骨缺损特点和体内降解特点。

Following 7 and 14 days of induction, type I collagen expressed positively in the osteogenetic induction medium and combination groups, but negatively in the PRP and control groups.

诱导7，14 d后，成骨诱导培养基组、联合组Ⅰ型胶原均呈阳性表达，富血小板血浆组、对照组Ⅰ型胶原始终呈阴性表达。

Immunohistochemical staining with an anti-type II collagen antibody demonstrated rich production of the type II collagen in the pericellular matrix from the chondrocytes.

用抗II型胶原抗体免疫组织化学染色证明在软骨细胞周围的基质中有丰富的II型胶原产生。

Phylogenetically, most of the collagens are highly conserved between different species, which suggests that collagens also share similar functions in mice and men.

尽管人和鼠眼之间有相当多的不同，特别是不同组织的胶原组成比例不同，但在人和鼠之间胶原具有相似功能。

And Pharaoh spoke to Joseph, saying, Your father and your brothers have come to you.

47：5 法老对约瑟说，你父亲和你弟兄们到你这里来了。

Additionally, the approximate flattening of surface strip using lines linking midpoints on perpendicular lines between geodesic curves and the unconditional extreme value method are discussed.

提出了用测地线方程、曲面上两点间短程线来计算膜结构曲面测地线的方法，同时，采用测地线间垂线的中点连线和用无约束极值法进行空间条状曲面近似展开的分析。