胶原

Results: The staining of VG, HE show that the subepidermal thickness were reduced , the arrange of collagen tended to uni...

结果：兔耳腹侧面增生性瘢痕局部注射苦参碱后，按时间段取材；VG和HE染色显示真皮层明显变薄，成纤维细胞数量明显减少，胶原排列趋于一致；12周后，对照组苦参碱组的增生指数、成纤维细胞数密度、胶原密度分别为3.25±0.89/2.15±0.12，4517.5±879.6/3551.2±234.1，39.89±14.12/28.75±10.87。

To solve this problem,one of the routes with good potential for success is to treat collagen with special modifier to implement high exhaustion chrome tannage by simply providing additional cross-linking sites or binding sites for chromium.

解决这一问题的一条有效途径就是在铬鞣前采用改性剂对胶原进行改性，通过给胶原分子上引入附加交联点和结合点以实现高吸收铬鞣。

Collagen is the most abundant protein in higher vertebrates, accounting for one-third of the total body protein, collagen resists stretching, is the major component of tendo , and contai one-third glycine and one-fourth proline or hydroxyprolinethe rigid r grou , and the lack of hydrogen bonding by peptide linkages involving proline and hydroxyproline, prevents formation of an ∝-helical structure and forces the collagen polypeptide chain into an odd kinked-type helix.

胶原螺旋是高等脊椎动物中最丰富的一种蛋白质，占动物体蛋白总量的1/3。胶原蛋白中含有1\3的甘氨酸和1\4脯氨酸或羟脯氨酸，能抵抗拉伸，是腱的主要组分。

METHODS: Fresh bovine tendo calcaneus collagen was dispersed in 0.5 mol/L acetic acid, co-precipitated with chitosan and lyophilized. Dry membranes were cross-linked in 0.05% glutaraldehyde for 24 hours. In vitro its degrading rate was measured by use of collagenase degrading test. The chitosan-collagen membrane was implanted to subcutaneous dorsal sites of SD rats. After implantation, histocompatibility, vascularity and degradation were observed in vivo.

以酸溶法制备胶原溶液，添加一定比例的脱乙酰化几丁质，冻干成膜，0 。0 5 %戊二醛溶液浸泡交联，行体外酶降解实验，检测其耐受酶降解能力；将制备的几丁质-胶原蛋白膜包埋于 36只 SD大鼠皮下，术后 3、5天，1、2、3、4、6、8和 12周取材，检测其组织相容性、血管化能力及材料在体内降解情况。

There were no significant different about the thickness of epidermis in ETE group and RTE group; The collagen fiber in ETE group is more tenuity and the distance between them were increased on the basis of RTE group showed; the I type collage content decreased distinctly.

结果： 极限扩张后皮肤真皮层明显变薄，表皮层厚度与RTE组相比无明显变化；真皮层胶原纤维排列稀疏、纤维束细小；弹力纤维广泛断裂；Ⅰ型胶原含量减低。

The S 2p, C 1s, N 1s and O 1s spectra were typically analyzed. Experimental result has demonstrated that using MUA/Au, Ag as the substrates, collagen immobilization process in wet cell system or in atmospheric environment did not have qualitative or quantitative difference. Firstly, our well cell system is feasible to carry out on-line collagen immobilization process.

实验结果显示：具有羧基之 MUA /Au，Ag 於真空湿室反应室中及传统大气环境下固定胶原蛋白，试片在两种环境所固定的胶原蛋白结构，在定性及定量分析上无显著差异，先证实在本真空湿室反应室中进行连续的蛋白质固定程序具体可行。

Myocardial fibrosis is characteristic by excessive fibrous tissue accumulation, collagen contents or ratio alteration in heart tissue. The abnormal collagen accrementition is the characteristic pathological change in viral heart disease including acute and chronic myocarditis and partial dilated cardiomyopathy.

心肌纤维化是指心肌组织中胶原纤维过量积聚或胶原成分和/或比例发生变化，是病毒性心脏病(包括急、慢性心肌炎和部分扩张型心肌病)的特征性病理表现。

The up-regulation of the expression of MMP-9 perhaps takes part in the accrementition and reconstitution of mesenchymal fibers (Ⅰ-type collagen dominates in mesenchymal, IOD ratio ofⅠ/Ⅲchanged). MMP-9 can facilitate inflammatory cell infiltration, aggravate the development of CAM.

2MMP-9的增高可能参与了骨骼肌间质纤维增生及其构成的改变(Ⅰ和Ⅲ型增多，Ⅰ型胶原与Ⅲ型胶原比值增高)，诱导炎性细胞浸润，加重慢性酒精中毒性肌病的发生发展。

Antibodies against col Ⅲ reacted strongly in the entire pterygial stroma. Conclusions Components of ECM are changed in the pterygium: the sub-epithelial connective tissues and vessels are more prominent in the pterygia than in normal conjunctiva tissues, and abnormal fibers are visible only in the deeper subepithelial connective tissues. This study documents the overexpression of LN and col Ⅲ. They may play roles in cellular adherency, migration and angiogenesis. Also this study documents the overexpression of MMP3 which may degrade ECM in the pathogenesis of the pterygium.

结论翼状胬肉组织中ECM的成分较正常球结膜发生改变，有大量的弹性纤维变性、胶原纤维增生及新生血管形成；col Ⅲ在翼状胬肉组织中表达增加，LN及胶原纤维可能对翼状胬肉中血管形成、细胞粘附和迁移及ECM重建起作用；MMP-3在翼状胬肉组织中表达增加，其对ECM成分的降解作用可能有助于翼状胬肉的形成和向角膜中央侵袭。

2709 Alkalic protease was used to hydrolyse dechromed chrome shavings , and the factors that may affect the collagen hydrolysis ratio, including the amount of 2709 alkalic protease, temperature, pH and time of hydrolyzing reaction, were studied.

研究了采用2709碱性蛋白酶水解脱铬革屑制备胶原水解产物时，影响胶原水解率的各种因素。

And Pharaoh spoke to Joseph, saying, Your father and your brothers have come to you.

47：5 法老对约瑟说，你父亲和你弟兄们到你这里来了。

Additionally, the approximate flattening of surface strip using lines linking midpoints on perpendicular lines between geodesic curves and the unconditional extreme value method are discussed.

提出了用测地线方程、曲面上两点间短程线来计算膜结构曲面测地线的方法，同时，采用测地线间垂线的中点连线和用无约束极值法进行空间条状曲面近似展开的分析。