胶原

The main components in hypodermis of mammiferous skin are collagens, amounting up to 70% of total proteins.

哺乳动物皮肤中真皮内的胶原蛋白含量约占70%，主要是Ⅰ型、Ⅲ型和少量Ⅴ型胶原蛋白。

Objective Effects of collagen degradation in hypertrophic scar by intradermal injection of collagenase were observed.

目的 观察胶原酶对肥厚性瘢痕胶原降解的影响，探讨它对HTS的治疗作用。

Methods Twenty DBA/1 mice were divided randomly into model group and control group with 10 in each, the model group were injected intradermally at the root of the tail with 100 μl emusion containing an equal volume of bovine type Ⅱcollagen solution and complete Freund's adjuvant on the 1st and 21 day. The control group were given 100 μl emusion containing an equal volume of complete Freund's adjuvant and glacial acetic acid.

取20只DBA/1小鼠随机分为模型组和对照组各10只，模型组分别于第1、21天自尾根部取3点皮内注射牛Ⅱ型胶原与褔氏完全佐剂充分乳化的胶原乳剂100μl，对照组同上方法注射褔氏完全佐剂与0.1M冰醋酸等体积乳化液100μl。

Appraised the clinical effect of the flavone of rhizome drynania on Senile Osteoporosis, according to the dynamic observation on integrative scores of lumbodorsal pain and lumbodynia,"VAS section grading method" on lumbodynia,"Barthel index rating method" on ADL, detected BMD on anterior-posterior position lumbar2~4 vertebra body and proximate of femur including neck/ward/troch, and determined the index of bone transition including BGP/PINP/ICTP through the radioimmunity method before and after treated half a year, then contrast intragroup and selfgroup. Depending on the standard of curative effect, contrast the difference of curative effect between two groups.

采用随机对照的方法，分为治疗组36例，对照组34例，依据对腰背痛及腰痛综合评分进行动态观察；依据"疼痛VAS线段分级法"对腰背痛（静止痛、翻身痛、久坐痛、起身痛、弯腰痛、步行痛、睡眠痛、叩击痛、压痛）进行量化动态观察；依据"Barthel指数评定法"对老年性骨质疏松症日常生活活动能力进行观察；采用双能X线骨密度仪对腰椎(L2-L4)、股骨近端各部位：股骨颈、股骨三角区、股骨粗隆进行骨密度定量检测；应用放射免疫法对骨转换指标进行测定，骨形成指标：骨钙素、Ⅰ型前胶原氨基端前肽；骨吸收指标：Ⅰ型胶原交联羧基末端肽等，评价骨碎补总黄酮治疗老年性骨质疏松症的临床效果。

OBJECTIVE: Using membrane guided tissue regeneration technique, to observe the healing velocity and quality of repairing rabbit radius segmental defect combined collagen membrane with allogeneic bone, further more, to contrast the result with pure collagen membrane.

目的：利用膜引导组织再生技术，观察胶原膜复合同种骨颗粒修复兔桡骨节段性骨缺损的成骨速度和质量，并与单纯胶原膜进行比较。

As collagen in the meshwork breaks down, it is replaced and repaired by new collagen secreted by fibroblasts.

随着胶原网打破了，这是更换和修理的新的胶原纤维细胞分泌的。

Seven patients aged 4 to 19 years, with myelomeningocele and high-pressure or poorly compliant bladders, were identified as candidates for cystoplasty. Each patient underwent bladder biopsy, and urothelial and muscle cells were grown in culture and seeded on a biodegradable bladder-shaped scaffold made of collagen, or on a composite of collagen and polyglycolic acid. About 7 weeks later, the autologous engineered bladder constructs were used for reconstruction, and implanted either with or without an omental wrap. After implantation, patients underwent serial urodynamics, cystograms, ultrasounds, bladder biopsies, and serum analyses.

年纪从4到19岁的7位脊髓脊膜膨出、罹有高压或者功能不良膀胱、被鉴定需进行膀胱成形术的病患，每一位病患接受膀胱切片，将上皮与肌肉细胞在膀胱形状的生物可分解的胶原支架或胶原聚羟基乙酸支架上加以培养；大约7周过后，形成一可自体移植的工程膀胱，移植时包覆或者未包覆网膜；移植后，病患进行一系列的尿路动力学、膀胱造影术、超音波、膀胱切片和血清分析。

Yrica rubra tannin, extracted from myrica rubra bark, was immobilized on collagen fibre through crosslinking reaction.

以胶原纤维为基质，通过交联剂将杨梅单宁固化在胶原纤维上制备吸附材料。

Methods Specimens of neurofibroma tissue, keloid and normal skin were collected. The distribution and expression of CTGF was measured by immunohistochemistry. The mRNA expression of CTGF, TGF-β1,ColⅠ and ColⅢ was detected by reverse transcription- polymerase chain reaction. Expression of CTGF protein was measured by western blotting.

收集神经纤维瘤组织、瘢痕疙瘩组织及正常皮肤组织标本，免疫组化检测CTGF的表达，逆转录-聚合酶链式反应方法检测组织CTGF、TGF-β1、Ⅰ型胶原及Ⅲ型胶原 mRNA表达，Western blotting检测组织CTGF蛋白的表达。

Nighty rats were randomly divided into the groups of control, myocardial infarction and doxycycline, which were given orally 48 hours before and 48 hours after MI with 30mg/Kg per day. Protein and mRNA extraction was done on left ventricular samples containing scar and myocardium together. Samples were assayed from 1 day to 4 weeks post-Mi. The activity of MMPs was measured by zymography and collagen amount by the method of chloramine T, the ratio of II III collagen was assessed by immunohistochemical stain. Protein and mRNA of MMP-2, 9, TIMP-1 were determined by Western-Blot and RT-PCR.

分为对照组、心梗组和治疗组(D组，术前两天至术后两天，口服Doxycycline，30mg／kg／天)，分别于术后第一天、术后一周、术后两周、术后四周取心肌组织，采用免疫组化测定胶原含量和Ⅰ／Ⅲ胶原比例，酶谱法测定心梗后MMP-2，9活性蛋白的表达规律，Western Blotting进一步确定酶谱法中所消化条带蛋白的属性，逆转录-聚合链反应法测定心梗后MMP-2，9和TIMP-1的mRNA的变化规律，运用Acuson Sequoia 512超声心动图机分别测定心梗组、治疗组在两周和四周时左室前壁、后壁厚度以及左心室舒张末内径和左室射血分数。

Plunder melds and run with this jewel!

掠夺melds和运行与此宝石！

My dream is to be a crazy growing tree and extend at the edge between the city and the forest.

此刻，也许正是在通往天国的路上，我体验着这白色的晕旋。