胞浆

Histoplasmosis: fever, weight loss, skin ulcers, difficulty in breathing, anemia, swollen glands.

组织胞浆菌病：发烧，体重下降，皮肤溃烂，呼吸困难，贫血，腺肿。

However, after that time, six patients died, four of whom had taken infliximab. The causes of death in those taking the drug included histoplasmosis 4 weeks after the final infusion; Listeria encephalitis 3 years afterward; prostate cancer 3.5 years afterward; and natural causes 10 months later. The two who received placebo died from a suicide and a cerebrovascular accident.

但在这之后，6例患者死亡：其中英夫利昔单抗组4例——1例患者在末次输注4周后死于组织胞浆菌病、1例患者3年后死于李斯特菌脑炎、1例患者3.5年后死于前列腺癌，1例患者10个月后自然死亡；安慰剂组2例患者分别死于自杀和脑血管意外。

In 18 patients studied, common infections included HPV and histoplasmosis. Ten patients developed one or more malignancies, including nine myelodysplasia/leukemia, one vulvar carcinoma and metastatic melanoma, one cervical carcinoma, one Bowen's disease of the vulva, and one multiple Epstein-Barr virus leiomyosarcoma.

在所研究的18例患者中，常见感染包括HPV和组织胞浆菌感染。10例患者出现1种或多种恶性肿瘤，包括9例脊髓发育不良/白血病、1例外阴癌和转移性黑色素瘤、1例宫颈癌、1例外阴鲍温病(Bowen's disease)及1例多发性EB病毒平滑肌肉瘤。

Research background: Choroidal neovascularization is a common cause of vision loss in patients, which often resulted from exudative Age-related macular degeneration、 pathologic myopia、 central serous chorioretinopathy、ocular histoplasmosis and angioid streaks, Rarely, CNV is seen in children, usually in association with inherited macular dystrophies. Despite extensive basic and clinical research, our knowledge of the complicated molecular mechanism of CNV is still limited, for these reasons currently used therapeutic approaches are insufficiently effective.

课题研究背景：脉络膜新生血管(choroidal neovascularization，CNV)是导致视力丧失的一种常见原因，多继发于渗出型年龄相关性黄斑变性、近视性黄斑变性、中心性浆液性脉络膜视网膜炎、眼组织胞浆菌病和眼底血管样条纹等眼病，在儿童罕见，主要与遗传性黄斑营养不良有关，尽管近年来进行了大量的基础和临床研究，但对CNV复杂分子机制的认识仍然非常有限，因此目前的治疗措施都不尽如人意。

One patient taking infliximab developed tuberculosis and one developed histoplasmosis. Five patients (four taking infliximab and one taking placebo) developed cancer. New autoimmune disorders developed in two patients taking infliximab and one patient taking placebo. Two patients developed optic neuritis and one developed a multifocal motor neuropathy; all three were taking the study drug.

英夫利昔单抗组1例患者发生结核病，1例发生组织胞浆菌病。5例患者(英夫利昔单抗组4例，安慰剂组1例)发生癌症。2例英夫利昔单抗组患者和1例安慰剂组患者新发自身免疫性疾病。2例患者发生视神经炎，1例发生多灶性运动神经病；这3例患者均服用了英夫利昔单抗。

Notable serious adverse events included culture-negative septic arthritis in a subject receiving leflunomide and fatal disseminated histoplasmosis considered unrelated to rAAV2-TNFR:Fc in a subject receiving adalimumab.

其他的严重不良反应包括1例服用来氟米特患者出现培养阴性的化脓性关节炎、1例用阿达木单抗治疗患者出现致命性播散性组织胞浆菌病（与 rAAV2-TNFR：Fc 无关）。

These cysts are lined by epithelium with eosinophilic cytoplasm and a hobnail morphology, and there is often ovarian-like stroma.

囊壁由含有嗜酸性胞浆的上皮围成，上皮细胞呈鞋钉状，常常有卵巢样间质。

Grossly, the tumors ranged from 0.7 to 17 cm, and exhibited a spongy or bubble wrap appearance reflecting the microscopic presence of variably sized cystically dilated tubules lined by a single layer of epithelium. The lining varied with a cuboidal, flat, and hobnail cell appearance, and the neoplastic cells had abundant eosinophilic cytoplasm and enlarged nuclei with prominent nucleoli.

大体上，肿瘤大小为0.7至17cm，海绵样或泡沫样外观，镜下观是大小不等的扩张成囊的管子，这些管子被覆单层上皮，上皮形态立方状、扁平状和鞋钉样，肿瘤细胞胞浆丰富、嗜酸，细胞核大，核仁明显。

Results The liver cells in model group were hydropic degeneration.

结果 模型组大鼠肝脏中可见肝细胞水肿、体积增大，胞浆疏松化，部分肝细胞出现脂肪变性，肝血窦狭窄，门管区炎细胞增多；bFGF表达增高，主要表达在肝小叶中央静脉周围。

Results: Expression of PAI-1, TIMP-1 and FN in kidney of diabetic rats began to increase in the second week of diabetes; PAI-1 and TIMP-1 mainly expressed in intracytoplasm of renal tubular epithelial cells, while FN mainly expressed in renal tubule matrix and glomerului; Their expression showed a tendency of increasing along with the progression of diabetes.

结果：PAI-1、TIMP-1及FN表达从糖尿病2周起较正常对照组明显增多(P.01)，PAI-1和TIMP-1阳性表达主要位于肾小管上皮细胞胞浆内，FN阳性表达主要位于肾小管间质和肾小球，且随着糖尿病进展有逐渐增加的趋势。

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。