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Significantly lower amount of glycogen was observed in spongiotropho- blasts 1asts especially in those glycogen cells of MXC mice compared with control ones.We found that MXC can disrupt reproductive function ,which resulted in dysgenesis and maldevelopment in mice.

①MXC可干扰孕小鼠的生殖功能和激素水平,孕鼠体质量和肝脏相对体质量随剂量的增加有下降趋势,而血清P含量降低,引起黄体数量和着床数减少,不良妊娠结局增加;②MXC可通过降低胎盘的糖原贮存。

Decidual tissue is a very complex and highly concordant tiny environment between mother and embryo during pregnancy, which is constituted of the variety cells such as extravi11ous trophoblast,endometrium cells, bone marrow cells, decidua l microphage,T cells and a few B cells and so on.

正常蜕膜组织是母-胎界面间一个非常复杂而又高度协调的微环境,它由多种细胞如侵袭至蜕膜的绒毛外滋养细胞(extravi11ous trophoblast,EVT)、子宫内膜源性细胞(如上皮细胞和血管内皮细胞)、骨髓源性细胞(如大颗粒淋巴细胞、蜕膜巨噬细胞、T细胞和少许B细胞)构成,这些细胞以及由这些细胞、母体和胎儿所分泌到蜕膜的细胞因子共同形成了母-胎间信息交流的平台,并对胚胎滋养细胞"有控性"侵袭、子宫内膜的免疫容受性、蜕膜化和胎盘的形成进行精细的调控。

Exercise during pregnancy has been the subject of much debate, the main concern being that it may interfere with fetal/placental demands, increasing the risk of abnormalities or compromising fetal development or growth.

运动在怀孕期间一直受到很大的辩论中,主要关注的是,它可能会干扰胎儿/胎盘的要求,越来越多的风险异常或损害胎儿发育或增长。

On the functional differentiation,we found and that the type II ras-GTPaseactivating protein (p100-GAP),which was specifically expressed in humanplacenta,was largely expressed in the highly-differentiated syncytiotrophoblastcells and moderately expressed in the cultured intermediate trophoblast cells.While in the non-differentiated cytotrophoblast cell line-NPC,no expression was observed.Its mRNA and protein expressingcharacterization was in consistent with that of hCGβ,which was one of the mostimportant markers of the trophoblast cell functional differentiation.In addition,the expressing amount of p100-GAP increased with the progressing of pregnancyand the syncytium formation in vitro.

细胞功能分化的研究结果表明:经重组质粒的构建获得特异表达于人胎盘的p100-GAP的cDNA探针后,从蛋白和分子水平证实p100-GAP大量表达于分化程度高的合体滋养层细胞,少量表达于体外培养的中间型滋养层细胞,而非分化的细胞滋养层细胞NPC则不表达,这种表达特性与作为滋养层细胞功能分化重要指标之一的hCGβ高度一致;p100-GAP表达量还随妊娠过程和体外合体化过程而逐渐增加。

Objective: To study the possible relationship between expressions of Matrix Metalloproteinase-2,-9 and the pathogenesis of preeclampsia in which trophoblast invasions is impaired.

目的:通过比较子痫前期和正常胎盘的滋养细胞MMP-2和-9的表达情况,探讨MMP-2和-9与子痫前期发病的关系。

The present study suggested that high levels of plasma IGF-1 of perinatal ewes may related to the growth and development of fetal sheep; cholic acid load may affect IGF-1 production in liver and/or the regulatory function of placenta.

本研究提示妊娠后期绵羊母体血浆高水平的IGF-1可能与胎儿生长发育有关;胆酸负荷可能影响了妊娠母体的肝功能或胎盘的调节作用。

The obvious indication of TGA is a newborn who becomes cyanotic in the transitional first day of life when the maternal source of oxygen is removed.

大动脉转位的明显的迹象是新生儿在其娩出后第一天里当来自胎盘的母体的氧断开后就出现紫绀。

It is currently considered that HDCP origins from the patho-physio changes of placenta,this kind of changes can further lead to the damage and disfunction of blood vessel endotheliocyte,and consequently,cause a serial of symptoms.

目前认为HDCP的发病起源于胎盘的病理生理改变,此改变进一步导致全身血管内皮细胞损伤和功能异常,从而引起一系列HDCP的临床症状。

The experiments suggest a relationship between (1) the FN cytoplasm location and the invasion of trophoblastic tumor and the FN cytoplasm location and the trophoblastic migration during normal secondary gestations.

纤维粘连蛋白(fibronectin,FN)作为间质细胞的胞外基质成分研究较多,在胎盘的分布状况也较常见[1,2],但对正常和异常滋养上皮的准确定位和功能的关系的全面系统报道研究未见报道。

Ethod Twenty trimester placentae from normal mature pregnancy between 38 and 40 weeks gestation and thirty-six placentae from pregnancy complicated with ICP were collected following termination of pregnancy.

DR3、BSEP及FIC1等三种基因在ICP胎盘的表达情况以及与ICP受损的胆汁酸排泌功能的关系值得研究。

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