胍

Second, guanidine chloride is another important denaturant used commonly for protein unfolding. It is believed that guanidine chloride and urea have a similar mechanism of action.

其次，盐酸胍是常用于使蛋白质变性的另一种重要变性剂，盐酸胍分子与蛋白质分子相互作用的机理和尿素的情形具有相似性。

In Chapter 2 of this thesis, the kinetic equation of substrate reaction in presence of denaturant has been derived. A re-examination of the effect of high concentrations of guanidine hydrochloride on the inactivation of papain, taking into consideration the effect of high concentrations of guanidine hydrochloride on the Michaelis constant, showed that, for papain, the substrate gives no protection on its inactivation.

我们在第二章中推导了变性剂存在下的底物反应动力学方程，并在考虑了高浓度盐酸胍对酶催化反应米氏常数的影响的前提下，根据推导的动力学方程重新分析了盐酸胍存在下木瓜蛋白酶的失活动力学，结果表明底物对木瓜蛋白酶的失活没有保护作用。

In this paper, the synthesis of alkyl-guanidine sulfate s and its flotation properties to diaspore, kaolinite, pyrophyllite and illite have been started.

本文系统地研究了烷基胍硫酸盐系列捕收剂的合成方法及其对一水硬铝石、高岭石、叶蜡石和伊利石的浮选性能，通过矿物的接触角测量、ζ-电位测定和红外光谱分析等手段，探讨了烷基胍类捕收剂与铝硅矿物的作用机理。

FPG,FINS,TG,TC,LDL-C of Model group were increased,ISI were decreased . The expression of PAI-1mRNA of adipose tissues was increased significantly (.2)Compairing with model group,the berberine and taurine group and combine group could significantly increase insulin sensitivity, decrease the expression of PAI-1mRNA in epiploon adipose tissue. The parameters mentioned above in combine group was better than other groups.

与正常组比较，模型组体重增加，血清 FPG、FINS、TG、TC 、LDL-C 升高，ISI 降低，血清中 FFA 浓度增加，内脏脂肪细胞肥大，脂肪组织中 PAI-1 mRNA 表达显著增加；(2)与模型组比，联合组、黄连素组、牛磺酸组、二甲双胍组均出现 ISI 升高和 PAI-1mRNA 表达减少，二者的协同作用优于单独作用，并优于二甲双胍组。

The behaviors of extracting gold from alkaline cyanide solution with guanidine and phosphoric-oxygenic compound were studied.

研究了胍与磷氧化合物从碱性氰化液中萃取金的性能，考察了胍、磷酸三丁酯和三丁基氧化膦的浓度对金萃取性能的影响。

Design, Setting, and Participants Case-control study of 21 patients with type 2 diabetes (studied 2003-2005) compared with 21 age- and sex-matched controls (studied in 2001) in Montpellier, France.

研究设计及方法：将新近诊断的，或曾经使用过口服降糖药，现仅有饮食及锻炼治疗的2型糖尿病成年病人随机分组，并接受二甲双胍缓释片或速效二甲双胍双盲治疗24周。

Respectively use chelex 100 resinate,boiling extraction,proteinase K digest/isopropanol precipitation,proteinase K digest/phenol/chloroformextra ction,alkaline lysis,guanidine thiocyanate lysis,guanidine hydrochloride lysis,spin column method to extract Mycobacterium tuberculosis DNA for multiplepolymerase chain eraction.

选择3份含结核分枝杆菌分别为4.325×103、6.857×104、5.356×105 Copies/ml的痰液，分别用Chelex 100树脂法、煮沸法、蛋白酶K消化异丙醇沉淀法、蛋白酶K消化酚/氯仿抽提法、碱裂解法、异硫氰酸胍裂解法、盐酸胍裂解法、离心柱法抽提结核分枝杆菌DNA作多重聚合酶链反应，显色法芯片检测结核分枝杆菌RFP和INH耐药基因。

(1)This three schemes mentioned above are effective for weight reduction, among them, the effect is best by using sibutramine and metformin together, which is second-best by using sibutramine simply and tertius by metformin.

①三种治疗方案对减肥均有疗效，其中西布曲明和二甲双胍联合治疗疗效最佳，单用西布曲明疗效次之，而单用二甲双胍疗效最差。

Methods: Glipizide gliclazide glyburide glimepiride gliquidone repaglinide nateglinide pioglitazone rosiglitazone metformin phenformin and tolbutamide added in the blank ground samples were extracted with 80% methanol and were separated from an ACQUITY UPLC DBH C18 column with a gradient mobile phase of acetonitrile - 0.2 % formic acid water solution. A tandem quadrupole mass spectrometer equipped with electrospray ionization source was used in positive ion mode multiple reaction monitoring was performed to quantify above mentioned compounds.

被添加在中成药制剂及其包装物中的二甲双胍、苯乙双胍、罗格列酮、吡格列酮、格列吡嗫娶瑞格列奈、甲苯磺丁脲、格列齐特、格列苯脲、那格列奈、格列美脲、格列喹酮等西药成分用80%甲醇提取，以乙腈- 0.2%甲酸水溶液为流动相梯度洗脱，在ACQUITY UPLC DBH C18色谱柱上分离，串联四级杆质谱检测，MRM方式采集并定量。

Box warning has been removed there is still some caution with heart failure but in reality all of the contraindications are based on a theoretical lactic acidemia which we have not really proven exists with metformin and so metformin remains the first line.

而实际上这些禁忌症都是基于理论上的乳酸性酸血症，而后者还没被证实确实是二甲双胍的不良反应。因此二甲双胍仍然是糖尿病治疗的一线药物。

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。