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KEY WORDS tetromethylpyrazine; aminoguanidine; diabetic nephropathy; vascular endothelial growth factor

关键词]川芎嗪;氨基;糖尿病肾病;血管内皮细胞生长因子

Objective To investigate the inhibitory effects of aminoguanidine,a selective inhibitor of inducible nitric oxide synthase, on mice stomach cancer and its′mechanism.

目的:研究诱导型一氧化氮合酶选择性抑制剂氨基对皮下接种MFC胃癌细胞株小鼠的抑瘤作用,探讨其抑瘤机制。

Aminoguanidine was supplied by Sigma, USA.

氨基由美国Sigma公司提供。

Objective To study the effects of inducible NOS inhibitor aminoguanidine on the expression of NOS in facial nerve and surrounding tissue of traumatic facial paralysis rats.

目的 研究诱导型一氧化氮合酶抑制剂氨基对创伤性面瘫大鼠外周面神经及周围组织一氧化氮合酶表达的影响。

When compared with DM group, the thyroid tissue injury of insulin intervention group and aminoguanidine intervention group were lessened to different degree.

胰岛素和氨基干预组甲状腺组织超微结构较DM组有不同程度的减轻。

Vitamin E and aminoguanidine attenuate the production of Dia.

结论AGEP-BSA能升高培养的大鼠血管平滑肌细胞中的Dia水平,维生素E 和氨基能明显抑制这一效应。

To explore the alteration of protein kinase C activity and the effect of aminoguanidine on diabetic glomerulopathy in streptozocininduced diabetic rats.

目的:研究糖尿病大鼠肾脏蛋白激酶C(protein kinase C,PKC)活性变化,探讨氨基对糖尿病大鼠肾脏的保护作用及其机制。

HMF in ZXTMN group were lower than in aminoguanidine group.

止消通脉宁有阻断肾脏组织非酶糖基化的作用,而对5-HMF的作用优于氨基

BACKGROUND: Previous studies demonstrate that inducible nitric oxide synthase and NO play important roles in both the occurrence and the recovery of acute soft tissue injury; however, their effect on the recovery of chronic injury, especially, the influence of aminoguanidine on recovery of acute soft tissue injury remains unclear.

背景:研究表明,诱导型一氧化氮合酶及一氧化氮在急性软组织损伤及其修复过程中起到重要的作用,但目前有关其在慢性软组织损伤修复过程中的作用,及氨基对其作用的影响尚不明确。

The therapeutic mechanism of tetromethylpyrazine and aminoguanidine on diabetic nephropathy may be inhibiting the over-expression of VEGF in kidney of diabetic rats.

川芎嗪联合氨基治疗可抑制糖尿病大鼠肾脏VEGF的过度表达,从而对糖尿病肾病起治疗作用。

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