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ABSTRACT The cardiac electrophysiological effects of agmatine were examined in guinea pig papillary muscle using intracellular microelectrode technique.

应用细胞内微电极技术,观察了基丁胺(agmatine, AGM)对豚鼠乳头肌细胞的电生理效应。

It has been well established that agmatine is an endogenous agonist at imidazoline receptors and noncatecholamine ligand at alpha - 2 adrenergic receptors (α2- AR).

业已证明,丁胺是一种内源性的咪唑啉受体激动剂和α2-肾上腺素能受体(α2-AR)的非儿茶酚胺配基。

It turns out that agmatine can inhibit PC12 cell line DNA injury induced by glutamate through block NMDA-R and improve mitochondrial function and reduce glutamate oxidative toxicity.

这说明基丁胺具有抑制PC12细胞DNA损伤的作用,其机制可能与其拮抗NMDA受体,改善线粒体功能和减轻谷氨酸的氧化毒性有关。

Present study, therefore, is to directly demonstrate whether I1-imidazoline receptor participates in the modulation to morphine dependence by agmatine, and to discuss its molecular mechanism in signal transduction aspect.

本文 旨在首次提供直接证据以阐明I1-眯唑啉受体是否介导了丁胺对吗啡依赖的调节,并探讨I1-咪唑啉受体在受体后水平抑制吗啡依赖的可能分子机制。

In 66 anaesthetized rats, the effects of local injection of agmatine on femoral, renal, and mesenteric vascular beds were investigated respectively by constant flow perfusion method.

在66只麻醉大鼠,分别采用后肢、肾脏和肠系膜动脉在体恒流灌注法,观察了向灌流环路中直接注射丁胺(agmatine, AGM)的血管效应,以所引起的灌流压增减反映血管的收缩和舒张。

When the nucleophile was alkanol, the reaction proceeded smoothly in the room temperature to give 6- alkoxyl pyrazolo[3,4-d]pyrimidin-4(5H)-ones.

并分离出了部分反应中间提,提出可能的反应机理,对这种反应的选择性进行了解析。

Forty-nine compounds including hydrazines, derivatives of aminoacid and guanidine, and alkaloids of Amaryllidaceae have been examined in vitro and in vivo.

并讨论了非肼类和肼类化合物(包括吲哚类、氨基酸类、类、石蒜生物碱、及酰肼类)等49种药物的初筛结果。

The condensation of 3 carbethoxy isoquinol 4 one with carbamidine, amidine, carbamide and sulfocarbamide gave isoquinolo pyrimidine derivatives, respectively and isoquinolo quinoline derivatives were synthesized by the reaction of o aminobenzaldehyde or o aminopiperonal with isoquinol 4 one.

报道了利用 3 乙氧甲酰基异喹啉 4 酮分别与、脒、脲及硫脲类化合物缩合反应合成异喹啉并嘧啶衍生物,邻氨基苯甲醛、邻氨基胡椒醛分别与异喹啉 4 酮反应合成异喹啉并喹啉化合物。6个新化合物的结构通过元素分析、红外光谱、核磁共振氢谱和质谱予以证

Objective To evaluate the therapeutic effects of aminoguanidine on cerebral ischemia-reperfusion damage in rats.

目的 探讨氨基对大鼠脑缺血再灌注后的血脑屏障的影响及对再灌注损伤的保护作用。

Objective To observe the effect of Aminoguanidine and Vitamin C on immune function of Streptozotocin-induced Diabetic Rats.

目的 观察氨基、维生素C对糖尿病大鼠免疫功能影响。

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