胆碱酯酶

Trev.=Lycopodium serratum Thunb., which are two new Lycopodium alkaloids with marked anticholinesterase activity and marked activity in increasing the efficiency for learning and memory of animals.

它们都具有很强的抑制胆碱酯酶活性和提高学习、记忆效率的功能，其中石杉碱甲经临床试验证明对重症肌无力、老年性健忘症和老年性痴呆症有一定疗效。

AIM: To investigate the antinociceptive effect of anticholinesterase agent physostigmine at different postoperative time, and the interaction of intravenous physostigmine with intrathecal morphine in rats.

目的：观察在术后不同阶段静脉注射胆碱酯酶抑制剂毒扁豆碱对鼠痛阈的影响，以及静注毒扁豆碱和蛛网膜下腔注射吗啡的药物相互作用。

The antinociception of physostigmine occurs at early postoperative time. The interaction of iv physostigmine with ith morphine indicates their synergistic effect.

胆碱酯酶抑制剂毒扁豆碱在术后早期产生镇痛作用；静注毒扁豆碱与蛛网膜下腔注射吗啡的联合给药呈协同效应。

The patients with IMS,when they have difficulty in breathing,should be put under treatmentwith respirator and treated with pralidoxime in addition to aˉtropine.

IMS患者出现呼吸衰竭时应使用呼吸机治疗，同时合理使用阿托品、胆碱酯酶复能剂。

The results showed that (1) the positive staining of ChAT was obviously observed in the cells of the three kinds of human pituitary adenoma, however, it was lower than that in normal human pituitary gland;(2) ACh had a similar effect on the proliferation of the three kinds of human pituitary adenoma cells. ACh at 0.1～10 μmol/L decreased the ［3H］TdR incorporation and the MTT A value in a dose-dependent manner. At the same time, ACh decreased the ratio of S or G2 phase pituitary adenoma cells significantly, but increased the ratio of G1 phase pituitary tumour cells markedly;(3) the effect of acetylcholine on the proliferation of human pituitary adenoma cells was inhibited by atropine, but not by tubocurarine;(4) ACh had no effect on the apoptosis of human pituitary adenoma cells cultured in vitro.

结果发现：(1)三种垂体腺瘤细胞中均有胆碱酯酶的表达，但明显少于正常垂体；(2)ACh对三种类型的人垂体腺瘤细胞增殖代谢的影响相类似，不同浓度的ACh能明显抑制体外培养的三种人垂体腺瘤细胞的增殖，呈明显的剂量效应关系，同时ACh能减少垂体腺瘤细胞进入S、G2期的细胞比例，而使处于G1期的细胞比例增加；(3)ACh的这种作用可被阿托品阻断，但不受筒箭毒的影响；(4)ACh对体外培养的三种人垂体腺瘤细胞凋亡无明显影响。

Methods Serum transferrin of 100 patients with different types of hepatitis were determined with immuno turbidimetry and compared with prothrombin time, serum bilirubin and serum cholinesterase.

采用免疫比浊法检测100例不同临床类型病毒性肝炎病人的TF，同时检测凝血酶原时间、血清总胆红素、血清胆碱酯酶。

Observe all the patients ingested dosage, treatment time after poisoning, cholinesterase activity on admission and the mortality; Observe the survived patients' duration of the recovery of CHE activity, the time interval to achieve atropinization from admission, the cumulative dosages of atropine to achieve atropinization, the cumulative dosages of atropine in the hospital and the incidence of intermediate syndrome.

观察全部病例的服用量，首诊时间，初诊时胆碱酯酶活力和死亡率，存活病例的CHE恢复时间，达阿托品化的时间，阿托品化的阿托品用量，病程中阿托品的总量及中间综合徵发生率。

The experimental vitiligo models were prepared by chemical decolour method in Guinea Pigs. And we choose the Meladinines recommeded level (0.15%) as high concentration, use the high, middle and low concentration levels (0.15%, 0.075 %, 0.03 %) of LMOP gels to progress the pharmacodynamics comparative study, 8-MOP tincture was used as controll group, observing the melanin distribution, the number of DOPA active cells, the number of hair follicles contented melanin, the levels of ChE and MDA of the experimental vitiligo models.

用化学脱色法制备豚鼠实验性白癜风动物模型，以市售敏柏宁酊的推荐使用浓度(0.15％)为最高浓度，设定LMOP凝胶低、中、高三个浓度组(0.03％，0.075％，0.15％)，进行药效学比较性研究，以8-MOP酊剂(敏柏宁酊稀释至含8-MOP 0.15％)为对照，考察其对皮肤黑素分布、DOPA阳性细胞数、含黑素毛囊数、胆碱酯酶及丙二醛的影响。

The rat with pyridostigmine that caused a 52% decrease in plasma ChE activity led to a significant enhancement of the hyperthermic response to open-field exposure.

给大鼠吡啶斯的明可引起血浆胆碱酯酶的活性降低52%，而导致暴露在开放环境中大鼠的体温过高反应明显提高。

All patients were treated by anticholinesterase,some patients were also treated by corticosteroid therapy,immunosuppressant or both.After24months follow up,all cases were relieved,and no myasthenic crisis occured.

全部病例用胆碱酯酶抑制剂治疗，部分加用肾上腺糖皮质激素或免疫抑制剂，病情均得到缓解，随诊至今无危象发生。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。