胆碱能的

The researchers found that higher anticholinergic burden is associated with worse physical function, both self-reported and performance-based.

研究人员发现，较高的抗胆碱能负担的方法，是与更糟的身体机能，无论是自报和业绩为基础的。

Recent evidence indicates that the cholinergic innervation of the left ventricle is functionally very important in some mammalian species.

近年来的研究显示在一些哺乳动物的心脏上，胆碱能神经在心室也有分布，且对左心室的功能有重要的调控作用。

Therefore, CRP could mediate E-LDL participating in the early stage of atherogenesis. CRP is an ancient conserved protein whose initial role as a pattern recognition molecule may have been to defend against bacterial infections, but whose present biological role appears quite complex. CRP is protective against a variety of bacterial infections and inflammatory stimuli as an opsonin. It is likely that the activity of CRP in humans is either pro- or anti-inflammatory is dependent on the context in which it is acting.

由于CRP的识别相可以结合被暴露出磷酸胆碱结构的E-LDL，形成E-LDL／CRP复合体，而内皮细胞表面能以高亲和力识别CRP的配体相，从而CRP-相性结构具有结合E-LDL，被内皮细胞捕获，引起脂质沉积和激活补体、触发炎症反应的可能性，这样可以解释早期动脉粥样硬化为何同时存在E-LDL、CRP、补体，而这三种物质在同时、同地出现绝非一个巧合。

The results indicated that an increase in BP, HR and the pressor response induced by the dPAG stmulation was caused by physostigmine microinjection without DKJ-21 pretreatment and no any change of BP and HR was observed after physostigmine administration with the pretreatment of DKJ-21. These results suggested that the location of central cholinergic system associated with the mechanism of the incidence of hypertension are mainly locate on the rVLM.

进一步的实验在正常血压大鼠上以DKJ-21预先处理后，由毒扁豆碱(0.4μg/0.1μl/site)微量注射至双侧rVLM引起的升压、加快心率、以及增强防御性升压反应的效应均被阻断，提示应激导致高血压时中枢内胆碱能系统活动异常增强的部位主要在于rVLM。

The experiment concentratedly study the influence of Bushen Huoxue Huatan Prescription from multilateral and multilager in treating the dementia rats whose cholinergic nerve cells are injured.The study has suggested that the deficiency of essence Qi of kidney and insufficiency of brain marrow and the blood stasis and phlegm located in brain is the fundmental pathogenesis of begin prostatic hyperplasia, thus we bring forward the referentially experimental basis for the prevention and treatment of Alzheimers disease.

实验从多侧面、多层次集中研究了补肾活血化痰方对胆碱能损伤痴呆大鼠产生的影响，首次揭示了老年性痴呆"肾虚髓减，瘀血痰浊阻脑"病机理论的科学内涵，从而为老年性痴呆的预防和治疗提供了可供借鉴的实验依据。

In recent years, ENK-IR neurons in myenteric plexus have been discovered. ENK is one of the important neurotransmitters in ENS. It can reduce the amplitude of cholinergic fEPSP and the release of Ach so as to inhibit contraction of smooth muscles.

近年发现在肠肌间丛神经元中有ENK-IR神经元，脑啡肽是肠神经系统中重要的神经递质之一，可降低胆碱能快速兴奋性突触后电位的幅度，减少乙酰胆碱的释放，抑制平滑肌的收缩。

Furthermore,activation of nicotinic receptors facilitates the release ofnorepinephrine in the spinal cord.

而且，胆碱能受体的活化有助于脊索的去甲肾上腺素的释放。

NGFP, in the membrane of somata and project fibers, binds to NGF produced in hippocampus and cerebral cortex, as tartget region of cholinergic neuron in BF.

我们以往的研究证实海马结构、大脑皮质内胆碱能传入纤维分布的减少是老年性记忆减退的一个重要原因。

In early development stage, muscarinic agonist carbachol significantly decreased the magnitude of the pacemaker current If but had no effect in late development stage.

我们发现，在胚胎发育的早期阶段，M胆碱能受体激动剂(muscarinic agonist carbachol，CCh)明显抑制If，但在胚胎发育的晚期阶段，CCh对If的抑制作用消失。

Gelatin microsphere is firstly made by encapsulating bFGF into gelatin by special manufacture process, then this microsphere was combinated into PLGA conduit or PLGA film.when used, we need only pack the injury peripheral nerve, injury spinal cord, wounded pars encephalic with the PLGA conduit. The conduit or film can slowly release buff which would be absorbed by around tissues.bFGF was already proved to be nutritious to the regeneration and alive of neuron and protect injury neuron.bFGF can also promote morphogenesia and division of nerve cell which would raise the survival rate of neuron, guide the generation of axon etc.bFGF is one of the important factors of sustaining the normal survival of cholinergic nerve.

使用时，只需将此材料贴敷外周损伤神经伤患处，脊髓伤口，或在脑部开颅手术后填充于术后创面，可有效地在伤口局部缓慢地释放并由机体组织吸收bFGF等神经营养因子。bFGF等已被证明具有神经营养作用，可促进神经元的再生与存活，保护受损的神经元。bFGF等对神经细胞兼有促进形态发生与分裂作用，具有提高神经元的成活率、诱导轴突向外生长等功能，是维持前脑基底部胆碱能神经元正常生存的重要因素。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。