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It has been demonstrated that TAK-147 is more potent and brain-specific AChE inhibition than tacrine and physostigmine, and has been approval potentiating choline acetyltransferase activity in cultured rat septal neurons more potent than donepezil, tacrine and revastigmine.

TAK-147 { 3-[l一(phenylmethyl(-4-piperidinyl]-l一门,3,4,5-tetrahydro-IH-l-be.azepln-8-yi(-l-propanone umarate }是日本最近研制的一个选择性胆碱酯酶抑制剂。TAK-147与毒扁豆碱和他克林相比是具有更强作用和中枢选择性的胆碱酯酶抑制剂。

Master the pharmacological action, clinical application and major adverse reaction of pilocarpine and of neostigmine(anti-cholinesterase).

掌握M 胆碱受体激动药毛果芸香碱、抗胆碱酯酶药新斯的明的作用、应用及主要不良反应。

Alzheimer′s disease animal models were made by damaging bilateral nucleus basalis of Meynert of elderly rats (20-22 month) with quinolinic acid(150 nmol in 2 μL for each NBM, given d 3 after administration of test drugs). Activity of choline acetyltransferase was measured by radiochemistry assay. One time training passive avoidance step-down and water-maze spatial localization task were used to observe effects of ginsenoside of stem and leaf in combination with choline on learning and memory of AD model rats.

应用喹啉酸(每侧150 nmol,2 μL,给受试药后d 3注射)损毁老年大鼠双侧Meynert基底核制备阿尔茨海默病动物模型,放射化学法测定胆碱乙酰基转移酶活性,一次性训练被动回避跳台实验和水迷宫空间分辨能力测试,观察人参茎叶皂甙和胆碱合用对AD模型大鼠学习记忆的影响。

Ladder outflow obstruction secondary to BPH can decrease the densities of cholinergic nerve and receptor and damage the function of cholinergic nerve in bladder detrusor.

PH引起膀胱出口梗阻,梗阻可导致逼尿肌胆碱能神经和受体的密度降低,以及胆碱能神经功能减退。

Self-catalyzed characteristic of choline chloride based on kinetics is further proved by studying the effect of reactant concentration during the process of synthesis of choline chloride from the chloroethanol and trimethylamine.

通过研究由氯乙醇和三甲胺反应合成氯化胆碱过程中反应物浓度的变化规律,进一步从动力学角度验证了氯化胆碱的自催化特性。

Objective: To investigate the protective effect of cholinergic anti-inflammatory pathway via vagotomy, vagus nerve stimulation and acetylcholinesterase inhibitors during lung ischemia-reperfusion injury.

目的:通过刺激和切断迷走神经或运用抗胆碱酯酶药物研究胆碱能抗炎通路对肺缺血再灌注损伤的影响。

" Acetylcholine: Ester of choline and acetic acid, a neurotransmitter active at many nerve synapses and at the motor end plate of vertebrate voluntary muscle s."

乙醯胆碱胆碱和醋酸的酯,是许多神经突触和脊椎动物肌肉运动神经终板的神经介质(在重症肌无力里,这种活动停止)。

In this paper, cholinergic neurons was mapped in the two kinds of birds (Emberiza rutila and Fringilla montifringilla) by using immunohistochemical method.The soma size and cell density of cholinergic neurons in the three song control nuclei, the higher vocal center, the robust nucleus of the archistriatum and area X, were measured and compared. Here we discussed the distribution of cholinergic neurons and their effect on the process of song producing and song learning.

本文以中国北方地区常见的两种鸣禽栗鹀和燕雀为材料,应用免疫组化方法,对两种鸣禽发声控制核团,即上纹状体腹侧尾核或高级发声中枢、古纹状体粗核、X区内胆碱能神经元的胞体大小和胞体密度进行了观察测量,旨在探讨胆碱能神经元在发声控制核团内的分布情况及其在鸣啭产生和学习过程中的作用。

To clarify the effect of lidocaine oncholinergic synapse, we reconstructed a cultured soma–somachemical synapse model consisting of two identified visceraldorsal 4 (VD4) and left pedal e-1 (LPeD1) neurons from the snail, Lymnaea stagnalis , in vitro , and used it to determine how lidocaineaffects cholinergic synaptic transmission.

为了阐明利多卡因对胆碱能突触的影响,我们从椎实螺属 stagnalis 的蜗牛离体重建了含两种已被鉴定的内脏背4( VD4)和左足 e-1( LPeD1)神经元的培养体细胞-体细胞化学突触模型,来研究利多卡因如何影响胆碱能突触传递。

Some researchers have found that SP could affect other neurons in enteric nervous system . However, little is known about the mechanism of SP on the myenteric cholinergic neurons.

本研究采用全细胞膜片钳技术和免疫细胞化学技术探讨了SP对豚鼠回肠肌间丛胆碱能神经元电活动的影响,为揭示肽类递质对胆碱能神经元的调节机制提供依据。

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According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm~150rpm时取得最大值,此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世,形体几无变化。

When I was in school, the rabbi explained everythingin the Bible two different ways.

当我上学的时候,老师解释《圣经》用两种不同的方法。