胆碱

objective to investigate the clinical significance of serum cholinesteraseand prealbuminin patients with chronic hepatosis.

目的 探讨慢性肝病患者血清胆碱酯酶、前白蛋白测定的临床意义。

In this thesis, a series of derivatives of -Huperzine A and benzylpiperidine were designed and synthesized, including nonsteroidal anti-inflammatory drug derivatives, heterocycle derivatives, aromatic derivatives and its sckiff derivatives, etc.

全部目标化合物进行了胆碱酯酶的活性测试，石杉碱甲类衍生物的乙酰胆碱酯酶活性比母体差，说明该类取代基在胺基上取代可能会使石杉碱甲衍生物的活性降低。

The benzylpiperidine derivatives show high activity of inhbiting against AChE in vitro, some of them are even more potent than -Hup A and Tacrine.

苄基哌啶类衍生物的胆碱酯酶活性发现，其与四氢吖啶的衍生物对AChE的抑制活性超过石杉碱甲和Tacrine。

HupA had only a weak inhibitory effect on the voltage-gated soldium channels at a concentration of 1 mM.

HupA对〓和〓的抑制作用与胆碱能系统无关，加入Atropine或Carbacol对HupA的抑制作用没有影响。

The effect of HupA on these voltage-activated currents in acutely dissociated hippocampal CA1 pyramidal neurons were summarized as follows

随着胆碱酯酶抑制剂的广泛应用，它们的药理作用机制以及可能引起的副作用也越来越受到人们的关注。

In general, we conclude that HupA can regulate the metabolism of APP in addition to improving the cholinergic neurotransmission and protecting neuronal cells against multiple injuries.

综上所述，本论文的研究提示，石杉碱甲除改善胆碱能传递功能、对抗多因素诱发的细胞损伤外，还对β-淀粉样蛋白的代谢过程具有调节作用。

The inhibition on these channels by HupA and Tacrine might form a potential toxic effect in the treatment of AD, because their 〓 values in inhibition of Cholinesterase are only 0.082 μM and 0.090 μM respectively.

石杉碱甲对电压门控钾通道的作用，与其胆碱酯酶抑制活性相比较（〓=0.082μM），相差近一万倍，因此不可能对AD的治疗有直接的联系，相反，它可能成为潜在的副作用。

Use biochemical method to observe the effect of electro-acupuncture on AchE、SOD、MAO、NO、NOS of senile dementia AD rat's brain tissue; use immunohistochemistry technique to observe protein kinase expression of hippocampal; use optical and electron microscope to observe morphosis change of rat's brain tissue; use in situ hybridism technique to observe aspartate receptor mRNA expression of hippocampal; use water and electric maze experiment to observe rat escape latent period and mistake times, to understand it's learning and memory ability.

分别用生化方法观察电针对AD大鼠脑组织胆碱酯酶、超氧化物歧化酶、单胺氧化酶、一氧化氮、一氧化氮合酶的影响；用免疫组化方法观察海马组织蛋白激酶的表达；用光、电镜方法观察大鼠脑组织形态结构的变化；用原位杂交方法观察海马组织天门冬氨酸受体rnRNA的表达；用水迷宫和电迷宫实验观察大鼠逃避潜伏期和错误次数，以了解其学习记忆能力。

Cholinesterase activities in brain were determined by microdosage hydroxylamine method.

结果 ：益智灵胶囊明显改善上述 3种模型小鼠的学习记忆能力，并能降低脑内胆碱酯酶的活性。

The results above suggest that there was the hypothyroid in brain tissue of AD model.

本研究结果表明：在AD模型中存在甲状腺激素代谢紊乱，主要表现为脑组织中甲状腺功能不足，是由于〓-脱单碘活性降低所致，这种酶活性降低的原因推测是AD模型胆碱能系统损害后引起脑内自由基增多而致。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。