胆汁酸

In order to identified phase Ⅱ conjugates, the aglycones were identifiedafter rat bile was treated with either glucuronidase or sulfatase firstly. Phase Ⅱ conjugates were also separated anddetermined for their molecular ions by LC-MS, at last they were verified by identifying characteristic product ionsor precursor ions by MS-MS.

胆汁经过葡萄糖醛酸酶或硫酸酯酶水解，鉴定其水解产物，从而确定Ⅱ相结合物，再通过LC-MS分离和确定分子离子峰，最后利用MS-MS寻找特征子离子和母离子的方法进行验证。

Two clinical phenotypes for citrin deficiency have been reported. One is adult-onset citrullinemia type II (CTLN2) and another is neonatal intrahepatic cholestasis caused by citrin deficiency.

Citrin缺陷病(citrin deficiency， CD)已报道两种临床表现型，一种是成人发病瓜氨酸血症Ⅱ型(CTLN2)，另一种是citrin缺陷导致的新生儿肝内胆汁淤积症。

and Result:(1 ) Endogastric administration of tan-extracted Rhubarb had no effecton gastric emptying and pancreatic enzyme secretion,buthepatic-bile secretion was increased.

胃饲去鞣质大黄水浸煎剂和腹腔、静脉给予没食子酸，观察对大鼠体重、摄食量、胃排空速度以及胰酶、肝胆汁分泌量的影响。

It was found that after the intravenous injection of bilirubin into a rat the concentration of both bilirubin and glucuronic acid in the bile rose.

在给大鼠静脉注射胆红素之后发现在胆汁中的胆红素和葡萄糖醛酸浓度升高。

S-adenosylmethionine is a naturally occurring molecule, which widely distributes throughout tissues and fluids. It has been one of the very important pharmaceuticals because of its essential role in transmethylation, transsulphuration and transaminopropylation.

S-腺苷蛋氨酸是一种广泛存在于各种组织和细胞中的生物小分子，具有转甲基、转硫和转氨丙基等重要生理作用，已成为治疗肝损伤、胆汁郁积和抑郁症等疾病的重要药物。

The gallbladder mucosa absorbs excess water and electrolytes and secretes hydrogen ions, concentrating and acidifying bile.

胆囊粘膜吸收多余的水、电解质，分泌氢离子，从而浓缩和酸化胆汁。

Methods:The guinea pig models with choletithasis were established by feeding on speical food induing choletithasis and treated with suspension of JXDC given through gastrotube.After one therapeutic course the total bilirubin,indirect bilirubin,calcium ion (Ca2＋),and β-glucuronidase were detected respectively.

用致石饲料诱发豚鼠胆石模型后，予以金熊胆安胶囊混悬液灌胃治疗，疗程结束后，检测胆汁中总胆红素、间接胆红素、钙离子（Ca2+）含量及β-葡萄糖醛酸酶活性，分别用重氮法、甲基麝香草酚蓝比色法和石井畅法测定。

The black bile, sourly bitter, rose in Bonasera's throat, overflowed through tightly clenched teeth.

又酸又苦的黑色胆汁，涌上伯纳塞拉的喉咙，从紧咬的牙关溢出来。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。