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Objective To explore the role of bile salt export pump in rat liver with bile duct obstruction and bile reflow.

胆酸是肝脏分泌到胆汁中最大量的有机酸,胆汁的主要成分。

Results showed that, bile salt levels were reduced, but phospholipids and cholesterol levels did not change markedly in both groups.

提示该制剂具有阻止胆固醇过饱和之成石性胆汁生成和阻止胆色素性成石性胆汁的生成作用。

But after bile salt stimulation, total bile acid and glutathione concentration in bile were significantly increased in AQP8 null mice compared with wild type mice.

本课题利用AQP8和AQP1基因敲除小鼠模型,系统地研究了水通道蛋白AQP8和AQP1在小鼠"原始"胆汁的形成和胆囊内胆汁浓缩过程中的作用。

MethodsThe antipyretic activity of ***PS was observed in rats with high temperature induced by dried yeast and 2,4-dinitrophenol; biliary duct cannula bile at 0.5,1,1.5,2,2.5 h after intraduodenal administration in rats was collected and counted to observe the effect of ***PS on biliary secretion;the weight of cholecyst in mice was counted to observe the effect of ***PS on the cholecyst of mice;the acute toxicity test of ***PS was done with mice.

方法采用干酵母、2,4二硝基苯酚致大鼠发热的模型观察玉米须多糖的解热作用;采用胆管引流法分别收集并计量给药后0.5,1,1.5,2 ,2.5 h的胆汁的方法观察***PS对肝脏分泌胆汁的影响;采用测定小鼠胆囊重量的方法观察***PS对胆囊的影响;对***PS进行了小鼠急性毒性实验。

Results: Elevated levels of unconjugated bilirubin(P.01)and Ga2+(P.05),decreased levels of total bile acid(P.01)and cholesterol(P.01)were found.

结果:乙肝病毒感染患者胆囊胆汁的非结合性胆红素、钙离子明显高于对照组(P.01,P.05),总胆汁酸、胆固醇明显低于对照组(P.01)。

It is suggested that coadministration with OM and inductor/inhibitor of microsomes should arouse the drug interaction.

胆汁排泄是OM的主要排泄途径之一,并且其胆汁排泄由转运蛋白介导,并依赖胆汁的生成。

Depending on the above research, it can be said that it has been provided experimental basic for the further research in the middling experiment of extracting the active component from the mixed bovine and ovine bile, supplied the reliable theory and possibility for comprehensive delevoping utilizing the bovine and ovine bile, and illustrated the distribution variation law of glycocholic acid in the blood-serum and texture of rat which is regarded to helping developing the biocherical drug from animal organs.

旨在为下一步开展从牛羊混合胆汁中提取有效成分的中试实验研究奠定试验基础,为牛羊胆汁的综合开发利用提供可靠的理论依据和可能性,同时为阐明甘氨胆酸在大鼠血清及组织中的分布和变化规律,开发脏器生化药物新资源提供线索。

Methods The antipyretic activity of SMPS was observed in rats with high temperature induced by dried yeast and 2,4-dinitrophenol; biliary duct cannula bile at 0.5,1,1.5,2,2.5 h after intraduodenal administration in rats was collected and counted to observe the effect of SMPS on biliary secretion;the weight of cholecyst in mice was counted to observe the effect of SMPS on the cholecyst of mice;the acute toxicity test of SMPS was done with mice.

采用干酵母、2,4二硝基苯酚致大鼠发热的模型观察玉米须多糖的解热作用;采用胆管引流法分别收集并计量给药后0.5,1,1.5,2 ,2.5 h的胆汁的方法观察SMPS对肝脏分泌胆汁的影响;采用测定小鼠胆囊重量的方法观察SMPS对胆囊的影响;对SMPS进行了小鼠急性毒性实验。

MethodsThe antipyretic activity of SMPS was observed in rats with high temperature induced by dried yeast and 2,4-dinitrophenol; biliary duct cannula bile at 0.5,1,1.5,2,2.5 h after intraduodenal administration in rats was collected and counted to observe the effect of SMPS on biliary secretion;the weight of cholecyst in mice was counted to observe the effect of SMPS on the cholecyst of mice;the acute toxicity test of SMPS was done with mice.

目的研究玉米须多糖的清热利胆作用及急性毒性。方法采用干酵母、2,4二硝基苯酚致大鼠发热的模型观察玉米须多糖的解热作用;采用胆管引流法分别收集并计量给药后0.5,1,1.5,2 ,2.5 h的胆汁的方法观察SMPS对肝脏分泌胆汁的影响;采用测定小鼠胆囊重量的方法观察SMPS对胆囊的影响;对SMPS进行了小鼠急性毒性实验。

Either of two bodily humors, black bile or yellow bile, in medieval physiology.

发怒液在古代生理学中人体黑色胆汁和黄色胆汁的任一种。

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