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胆汁

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"Bile contains bile acids and salt s, cholesterol, and electrolyte chemicals that keep it slightly acidic."

胆汁中包含胆汁酸和胆汁盐、胆固醇及电解质等,保持胆汁呈微酸性。

The data showed that, when adminisered for two weeks, cholagogue dry syrup significantly decreased both biliary and serum 33.5 kDa vesicular protein in cholesterol stone patients, while sodium cholate and control groups showed no significant changes.

在不同人群胆汁泡蛋白的含量差异有显著性;利胆冲剂等溶石防石药物能降低胆汁和血清33.5kd泡蛋白含量,改变胆汁致石性,为其临床应用提供了一定的理论依据。

Objective To explore the effect of high serum concentration of bile acids on energy metabolism of liver.Methods Bile acids were continously infused into the Wistar rats to simulate the serum concentration change of patients with obsturctive jaundice.Serum bile acids concentration,arterial blood ketone body ratio and energy charge of liver were determined.Results Aterial blood ketone body ratio and energy charge of liver decreased with the increase of serum bile acids concentration.Conclusion High serum concentration of bile acids plays an important role in hepatic fumction injury caused by biliary obstruction.

目的 探讨高胆汁酸血症单一因素对肝脏能量代谢的影响方法经Wistar大鼠颈内静脉持续给予外源性胆汁酸,升高其外周血清中胆汁酸浓度,模拟阻塞性黄疸患者外周血清中胆汁酸的变化规律,观察腹腔动脉血酮体比值及肝组织能荷变化,时间一周结果随外周血清中胆汁酸浓度的升高,腹腔动脉血酮体比值、肝组织能荷均呈进行性下降结论高胆汁酸血症时肝脏能量代谢受损,表明在阻塞性黄疸患者肝功能损害中高胆汁酸血症起了重要作用

Infusion of theChinese prescription "Ying-chen dandao tang" in 28 cholelithiatic patients who had had cholecystectomy choledochotomy with a "T" tube drainage (15 cases in experimental group and 13 cases in control group).

发现,在胆酸丢失、胆汁成石指数增高、胆汁成石性增高的情况下,应用该制剂时,胆汁成石指数无明显变化;并且胆汁中总胆红素、非结合胆红素浓度及胆汁UCB/T Bil%值等均较注药前明显降低。

The mean conˉcentrationsof the total bile acid in the gallbladders were respectively77.53±11.93,51.81±8.12and53.27±7.04in group DM,CH and DMCH,but it was79.28±18.28in group N.Combined bile acids(both glycocholic acid and taurocholic acid)were apparently lessened and the ratio of cholic acid and chenodeoxycholic acid was rised in group DM,CH and DMCH,the concentrationsof cholesterol were respectively5.31±0.81,5.69±2.20and5.12±1.47,but0.86±0.20,in the group N;those of phospholipd were respectively0.35±0.16,0.52±0.18and1.38±0.34,but0.59±0.28,group N.

胆囊胆汁成分分析中,DM组、CH组和DMCH组总胆汁酸分别为77.53±11.93、51.81±8.12和53.27±7.04,N组为79.28±18.28;与N组比较结合胆汁酸减少,其中甘氨胆汁酸盐与牛磺胆汁酸盐均减少;鹅去氧胆酸减少,胆酸/鹅去氧胆酸比值升高;胆汁胆固醇分别为5.31±0.81、5.69.20和5.12±1.47,N组为0.86±0.20;磷脂分别为0.35±0.16、0.52±0.18和1.38±0.34。

Stones were seen in the gallbladder of12/12cases in either group DM and CH,and11/12in the group DMCH.The mean conˉcentrationsof the total bile acid in the gallbladders were respectively77.53±11.93,51.81±8.12and53.27±7.04in group DM,CH and DMCH,but it was79.28±18.28in group N.Combined bile acids(both glycocholic acid and taurocholic acid)were apparently lessened and the ratio of cholic acid and chenodeoxycholic acid was rised in group DM,CH and DMCH,the concentrationsof cholesterol were respectively5.31±0.81,5.69±2.20and5.12±1.47,but0.86±0.20,in the group N;those of phospholipd were respectively0.35±0.16,0.52±0.18and1.38±0.34,but0.59±0.28,group N.

胆囊胆汁成分分析中,DM组、CH组和DMCH组总胆汁酸分别为77.53±11.93、51.81±8.12和53.27±7.04,N组为79.28±18.28;与N组比较结合胆汁酸减少,其中甘氨胆汁酸盐与牛磺胆汁酸盐均减少;鹅去氧胆酸减少,胆酸/鹅去氧胆酸比值升高;胆汁胆固醇分别为5.31±0.81、5.69.20和5.12±1.47,N组为0.86±0.20;磷脂分别为0.35±0.16、0.52±0.18和1.38±0.34。

It was observed that, at the doses of 50 mg/kg and 100 mg/kg, geniposide could significantly increase the biliary secretion after intraduodenal administration, while crocins showed no effect.

结果显示西红花苷50和100 mg/kg剂量均不增加大鼠的胆汁流量,而京尼平苷50和100 mg/kg剂量均可显著增加大鼠胆汁流量,降低胆汁内胆固醇含量,增加胆汁内HCO-3浓度,但对胆汁酸,胆红素,〔Ca2+〕含量无显著影响。

Approximately some 1/4 unio primary bile acid in the jejunum,the ileum and the colon upside ,with the effect of enzyme's catalysis,produces the deoxycholic acid,the lithocholic acid ,the bear deoxycholic acid and etc.

大约有1/4的结合型初级胆汁酸在空肠、回肠及结肠上段,在细菌的酶的催化下,进一步生成去氧胆酸、石胆酸、熊去氧胆酸等次级胆汁酸。C·胆汁酸的合成:肝细胞合成的胆汁酸与甘氨酸或牛磺酸结合,形成结合型胆汁酸,分泌入胆道。

When the swine's bile acid, made from the waste liquid of swine's bile after bilirubin is extracted, is used as an antitussive medicine to treat the mice's cough induced by SO2 the following result is recorded: The swine's bile acid is effective in prolongating the cough latency and decreasing the cough frequency per unit time.

本文利用提取胆红素后的猪胆汁废液所制备的猪胆汁酸,作对SO_2诱发咳嗽的正常NIH系小白鼠镇咳效果观察。结果表明;猪胆汁中的胆汁酸对SO_2诱发咳嗽的小白鼠具有延长诱发咳嗽潜伏期和减少单位时间内咳嗽次数的效果。

To study the relationship between gastric pH and bilirubin absorption value in bile reflux gastritis, we simultaneously assessed the changes in gastric pH and bilirubin absorption value during 24h in 22 patients with bile reflux gastritis using ambulatory 24h pH meter and bilirubin monitoring technique.

研究胆汁反流性胃炎患者胃内 pH值与胆汁反流的关系。胆汁反流性胃炎患者 2 2例,应用便携式pH及胆汁监测仪同步监测胃内 2 4h的 pH值及胆红素吸收值。

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