胆固醇

Methods: Ninety three female with adiposis were assessed for cholesterol, triglycerides, HDL-C, HDL2-C, HDL3-C, LDL-C and VLDL-C.

同时测量93例肥胖病妇女的腰围、腹围、臀围、腰围臀围比值（WHR1）和腹围臀围比值（WHR2），并测定血清总胆固醇、甘油三酯、高密度脂蛋白胆固醇、高密度脂蛋白-2-胆固醇（HDL2-C）、高密度脂蛋白-3-胆固醇（HDL3-C）、低密度脂蛋白胆固醇和极低密度脂蛋白胆固醇。

Methods: Ninety three female with adiposis were assessed for cholesterol, triglycerides, HDL-C, HDL2-C, HDL3-C, LDL-C and VLDL-C. At the same time the waist circumference was measured from the midpoint between the lower rib and the upper margin of the iliac crest (waistline 1) and the level of umbilicus (waistline 2). The hip circumference was measured at the greatest girth of the gluteus and waist-to-hipratio was calculated (waist circumference/hip circumference).

同时测量93例肥胖病妇女的腰围、腹围、臀围、腰围臀围比值(WHR1)和腹围臀围比值(WHR2)，并测定血清总胆固醇、甘油三酯、高密度脂蛋白胆固醇、高密度脂蛋白－2-胆固醇(HDL2-C)、高密度脂蛋白－3-胆固醇(HDL3-C)、低密度脂蛋白胆固醇和极低密度脂蛋白胆固醇。

But when the cholesterol was substituted by its oxide result, the membrane life time extended to nearly 60 hrs ;besides the diameter of the hole on which the membrane exists 、temperature、PH value cause great effects to the life time of the membrane, and the diameter was the most important element. When the diameter larger than 3mm it is almost no way to form a membrane on the hole under experiment condition. Between 1mm and 3mm it has a better result by change the prescription of the membrane. when it is 0.5mm all the membrane can last more than 40 hrs ,and the prescription like Och : phosphatidylcholine / cephalin＝4:1; 3:1; 2:1; 1:1; 2:3 need the request of the experiment basically, when cooperate with multi hole structure it is very to detect the concentration and found the model.

研究结果说明，成膜在普通胆固醇/磷脂配方下不能达到满意的结果，无论如何改变外界条件成膜始终超不过7小时，而将胆固醇换成氧化胆固醇再和磷脂按照一定配比的时候，成膜时间则大大延长，可达60h左右；另外除成膜配方，成膜孔径、温度、PH值等因素对成膜有着很重要的影响，成膜孔径对膜的影响最为关键，在3mm以上的孔径时成膜比较困难，在1－3mm适当提高成膜液浓度可以改善，孔径为0.5mm左右成膜比较稳定基本都能达到40h以上，合适的几个配方如卵/脑磷脂：氧化胆固醇＝4：1；3：1；2：1；1：1；2：3基本满足实验要求，配合一板多孔结构，可以保证单位时间的离子传输量的检测和计算。

Cholesterol gallstones formed in C57L mice and fatty livers developed in AKR mice. Conclusions Biliary cholesterol hypersecretion is the key pathophysiological defect of gallstone formation, lith genes have effects on biliary cholesterol hypersecretion and susceptibility to cholesterol gallstone formation in C57L mice. Lithogenic bile is formed at the canalicular membrane and precedes the development of cholesterol gallstones. It is most likely that cholesterol and bile acid hyposecretion make the AKR strain susceptible to the development of fatty livers and resistant to gallstone formation.

结论胆道胆固醇的高分泌是胆囊胆固醇结石形成的主要病理生理基础，结石基因决定了C57L鼠肝内胆汁中胆固醇的高分泌和胆囊胆固醇结石的易患性，成石胆汁形成在肝内胆管，先于胆囊结石的形成；肝内胆汁中胆固醇和胆酸的低分泌可能与AKR鼠脂肪肝的发生和胆囊结石的免患性有关。

Present study aims to evaluate the effect of proso millet prolamin on cholesterol metabolism in mice, by comparing the concentration of plasma total cholesterol, high-density lipoprotein cholesterol with triglyceride of mice given the diets containing casein, soy protein isolated or PMP (supplemented with 1.82%Lys and 0.23%Trp).

比较了分别饲喂酪蛋白、大豆分离蛋白、黄米醇溶蛋白小鼠的血清总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇，甘油三酯浓度和动脉硬化指数，旨在评价黄米醇溶蛋白对小鼠胆固醇代谢的特定作用。

Methods Rabbit model was adopted with gallstone induced by high cholesterol diet. Dynamic study on the serum lipoprotein cholesterol, hepatic total cholesterol, bile cholesterol and glycocholate, and low density lipoprotein recepter activity of hepatocytes had been conductd for the test and control groups after 1,2,3 and 4 weeks respectively.

采用高胆固醇膳食诱发兔胆囊结石模型，对进食高胆固醇膳食后1，2，3，4周实验组和对照组血清脂蛋白胆固醇、肝脏总胆固醇、胆汁中胆固醇和甘氨胆酸，肝细胞低密度脂蛋白受体活性变化进行了动态研究。

Methods: Foty healthy New Zealand white rabbits were randomly divided into four groops. Control groop was fed with normal diet for 10 weeks, model groop was fed with 1.5% cholesterol diet plus normal diet; APS groop was fed with 1.5% cholesterol plus 12.0mg/kg APS plus normal diet; Captopril groop was fed with 1.5% cholesterol plus 15.0mg/kg Captopril plus normal diet. After ten weeks' experiment, the concentration of each group's Triglyceride, Total Cholesterol, High Density Lipoprotein Cholesterol, C Reactive Protein, Nitric Oxide, Maleic Dialdehyde and Endothelin-1 were measured, so was the activity of superoxide dismutase.

将40只雄性新西兰兔随机分为4组，每组10只，对照组餵普通饲料；模型组：普通饲料加质量分数为1.5%的胆固醇餵养；黄芪多糖组：普通饲料加质量分数为1.5%的胆固醇餵养，同时腹腔注射APS(12.0mg/kg)；卡托普利组：普通饲料加质量分数为1.5%的胆固醇餵养，同时灌喂卡托普利(15.0mg/kg)；10周后，测定各组空腹血清或血浆三脂酰甘油、总胆固醇、高密度脂蛋白胆固醇、一氧化氮、内皮素-1(ET-1)、丙二醛、C反应蛋白含量以及超氧化物歧化酶活性，并计算主动脉内膜粥样斑块面积。

Methods Twelve rabbits fed with high-cholesterol diet for 8 weeks wererandomly divided into two groups:(1) high cholesterol group (n=6):maintained on high cholesterol diet for 6 weeks;(2) niacin group (n=6):the same cholesterol diet plus niacin 200mg·kg~(-1·d~(-1) for 6 weeks. Controlgroup (n=6) was fed with normal diet for 14 weeks. Subcutaneousadipose was collected from inguen for RNA analysis. Leptin and MCP-1levels in serum and adipocytes culture supernatant were measured byELISA.

选取12只健康雄性新西兰兔给予高胆固醇饲料培养8周，建立高胆固醇兔模型后，随机分为：(1)高胆固醇组：继续饲以高胆固醇饲料6周；(2)烟酸治疗组：在饲以高胆固醇饲料的基础上给予烟酸缓释剂0.2g.kg~(-1)。d~(-1)，共6周；另选普通饮食14周雄性新西兰兔(n=6)作为对照组。

The hydrophobic core serves as a reservoir for water-insoluble drugs.Hence,these nanoparticles can be used as carriers for hydrophobic drugs.For the synthesis of cholesterol-modified glycol chitosan conjugates,a carboxyl group was initially introduced to cholesterol molecule using succinic anhydride,and then covalently coupled with the primary amino group of glycol chitosan in the presence of 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride and N-hydroxyl succinimide.

本文采用二步反应将胆固醇接枝到乙二醇壳聚糖，首先将胆固醇进行羧基化，将胆固醇与琥珀酸酐反应生成胆固醇半琥珀酸酯，然后用1-乙基-3-(3-二甲基氨丙基)碳二亚胺盐酸盐与N-羟基琥珀酰亚胺作为偶联剂，将胆固醇半琥珀酸酯的羧基与乙二醇壳聚糖主链的氨基进行反应，得到胆固醇疏水改性乙二醇壳聚糖共聚物。

This experiment was made to investigate the changes of lipopro tein li pase and hepatic lipase activity and their effects on gallstone formati on in rabbit model in which the stones were induced by high cholesterol diet.Act ivities of plasma LPL and HL were determined; other data including concentratio n of plasma lipoprotein cholesterol, concentration of bile cholesterol and bile acids were also obtained.

为研究肝脂酶及脂蛋白脂酶在胆固醇结石成石过程中的变化及其对成石的影响，采用高胆固醇膳食诱发兔胆囊胆固醇结石模型，观测对照组及高胆固醇膳食1、2 、3、4周组动物血浆脂蛋白脂酶、肝脂酶活性、血浆脂蛋白胆固醇及胆汁中甘氨胆酸、甘氨脱氧胆酸、胆固醇的变化。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。