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For clinical research, its healing effects on acute ileus, acute pancreatitis, postoperative gastrointestinal disorder, delayed gastric emptying, gastrointestinal floating caused by mechanical ventilation as well as its influence on multiple organ dysfunction syndrome were reviewed; experimental research confirmed that Dachengqi decoction can enhance experimental rats' antibacterial capability, effectively regulate gastrointestinal motility and reduce antiperistalsis, promoting the recovery from digestive disorders.

临床研究阐述了其在治疗急性肠梗阻、急性胰腺炎、治疗术后胃肠功能障碍、治疗胃排空障碍,治疗机械通气所致胃肠胀气、对MODS的影响等六方面的研究及应用;实验研究证实了大承气汤可提高试验用小鼠的抗菌能力,并且可有效调节胃肠动力,减少胃肠逆蠕动的发生,从而促进消化障碍性疾病的康复,同时大承气汤可以有效防治内毒素血症和多器官功能损害的发生,并可提高严重创伤感染患者的免疫功能。

Being a new approach for treatment of gastrointestinal atony in ruminants, the carbonate buffer mixture can eliminate the gastrointestinal atony originated from the over acidity in gastrointestinal canal.

从而认为,对起因于胃肠酸碱环境改变的酸过多性胃肠弛缓疾病投服碳酸盐缓冲合剂可有效纠正胃肠弛缓状态,为反刍兽胃肠弛缓开辟了新的防治途径,创立了又一个病因一发病机理疗法。

ObjectiveTo observe the effect of Weichangshu on gastrointestinal motility disorder caused by Atropine in mice,and to explore its mechanism.

目的观察胃肠舒对阿托品致胃肠动力障碍小鼠胃肠运动的影响,探讨其作用机制。

Ecr could promote the gastrointestinal motility, which has some dose-effect relationship. The effect on the gastrointestinal motility of Ecr has no significant difference with the domperidone and prepulsid. The mechanism may be that Ecr could affect the activity of the DVC in the spinal cord, and sequentially the activity of pneumogastric nerve were regulated.

白萝卜提取物对胃肠动力有较为明显的促进作用,这种促动力作用存在着一定的量-效关系;白萝卜提取物促进胃肠道动力的作用与经典的促胃肠动力药物对比没有显著性差异;白萝卜提取物促进胃肠动力的作用机制存在通过对支配胃运动的延髓迷走复合体的激活作用,进而调节迷走神经而实现其对胃运动的调节。

Resul ts:Besides the structural changes caused by operation,barium meal rev ealed:①decreased gastrointestinal tonicity and abnormal configuration.②hypokin esis and incoordination of stomach.③moderate gastric retention but with normal emptying of liquid.

结果:除手术引起的胃肠结构改变外,胃肠钡餐还显示:①胃肠张力降低、形态失常;②胃肠动力减弱,运动不协调;③中等量胃潴留,但液体排空正常;④胃肠位置呈中线性变化但无出口狭窄梗阻。

This position statement has been endorsed by the American Society for Gastrointestinal Endoscopy, the Society for Healthcare Epidemiology of America, the Joint Commission on Accreditation of Healthcare Organizations, the American College of Gastroenterology, the American Gastroenterological Association, the American Society of Colon and Rectal Surgeons, the Society of American Gastrointestinal Endoscopic Surgeons, the Society of Gastroenterology Nurses and Associates, the Association of Perioperative Registered Nurses, the Association for Professionals in Infection Control, and the Federated Ambulatory Surgery Association.

本状况报告的认可机构包括为美国胃肠内镜检查术学会、美国健康护理流行病学会、健康护理组织水准鉴定联合委员会、美国胃肠病学院、美国胃肠病联合会、美国结肠与直肠手术学会、美国胃肠病内镜检查手术学会、胃肠病学护士与同事学会、围产手术注册护士协会、感染控制职业者协会、及联邦门诊外科协会。

Based on this,We designed a series of experiments to study the treatment and its mechanism of Iridoids composition of Valeriana jatamansi Jones of the IBS animal model.1 Research on Iridoids composition of Valeriana jatamansi Jones in the role of gastrointestinal function.1.1 Effection of Iridoids composition of Valeriana jatamansi Jones on gastrointestinal function of normal miceMethods:Compared with normal group and YJBH group,mice which has given Iridoids composition of Valeriana jatamansi Jones as 71.2mg/kg,35.6mg/kg,17.8mg/kg,8.9mg/kg was detected gastric emptying and small intestinal propulsion after 4 days drug given.Results:Compared with normal group,gastric emptying and small intestinal propulsion in 35.6mg/kg and 17.8mg/kg group was inhibited.

课题通过观察蜘蛛香环烯醚萜对正常及IBS模型动物的胃肠道功能、精神活动的影响,以及蜘蛛香环烯醚萜干预下IBS大鼠结肠、血清、中枢5-HT含量,结肠5-HTR3A受体的mRNA和色氨酸羟化酶(TPH1)的mRNA表达,结肠和血浆中SP和VIP含量以及结肠中肥大细胞分布,探讨蜘蛛香环烯醚萜对腹泻型IBS的治疗作用及其作用机理,为临床治疗IBS提供实验依据。1蜘蛛香环烯醚萜对胃肠功能的作用目的:探讨蜘蛛香环烯醚萜对胃肠功能的影响1.1蜘蛛香环烯醚萜对正常小鼠胃肠功能的作用方法:正常小鼠灌胃给予蜘蛛香环烯醚萜71.2mg/kg、35.6mg/kg、17.8mg/kg、8.9mg/kg与空白组和越鞠保和丸组对照,给药4日后测定动物的胃排空率和小肠推进率。

Objective:The study mainly utilize the raphanus which is a edible Chinese officinal herb and has little side-effect, easily accepted, steadly effect, and so on, to exploit its pharmacological value on gastrointestinal motility. By observing the effects of the crude extract of radishon the electrogastrogram,gastric emptying and small bowel peristalsis activity of the rats in vivo ,the effects of Ecr on gastrointestinal motility could be manifested. Furthermore, the contrast study about the effects of gastrointestinal motility was also observed among Ecr domperidone and prepulsid. The mechanism was explored by observing Ecr on the expression of Fos protein of the dorsal vagal complex.

目的:本研究主要利用十字花科萝卜属植物白萝卜作为食源性中药,具有副作用少、易被接受、作用稳定等特点,通过白萝卜提取物(The crude extract of radish,Ecr)对在体大鼠胃排空、肠推进、胃电活动的观察,并与经典的促胃肠动力药物进行对比观察,研究提取物对大鼠胃肠动力的作用;进一步通过研究提取物对大鼠中枢支配胃运动的迷走复合体(Dorsal vagal complex,DVC)中Fos蛋白表达的影响,从而反映DVC被激活的情况,来探讨白萝卜提取物促进胃肠动力的机制,从而为其在胃肠动力相关的功能性疾病的治疗上的应用提供实验基础和理论依据。

Results:eighty-one of 129 MODS patients had gastrointestinal failure and the morbidity of gastrointestinal failure was 62.8%,in whom 54 patients received rhubarb therapy and 33 patients(61.1)were all eviated.Whereas only 7(25.9%) out of 27 patients suffered from gastrointestinal failureinnon-rhubarb treatment group were improved.There was as ignificant difference between the two groups(P.01).Furthermore,28(51.9%) out of 54 MODS patients accompanied by gastrointestinal dysfunction were survive dafter rhubarb treatment,whereas 6(22.2%) of 27 MODS patients suffered from gastrointestinal dysfunction were survived in non-rhubarb treatment group.

其中54例患者接受大黄治疗,有效率为61.1%;27例患者为非大黄治疗组,胃肠功能恢复率为25.9%,2组间有显著性差异(P.01)。54例MODS伴胃肠功能障碍患者接受大黄治疗后,有28例患者存活,存活率为51.9%;27例MODS伴胃肠功能障碍患者接受其它胃肠动力剂治疗后有6例患者存活,存活率为22.2%。29例MODS不伴胃肠功能障碍的患者接受大黄治疗后有12例存活,存活率为41.4%;19例MODS不伴胃肠功能障碍者接受其它胃肠动力剂治疗后,有7例存活,存活率为36.8%。

A community sample of 40 RAP consulters, 41 RAP nonconsulters,and 36 pain-free controls and their mothers completed questionnaires on GI and non-GI symptoms, school absences, psychological symptoms, coping, self-esteem, and behavioral and cognitive responses to RAP.

调查对象来源于同一个社区,包括40例RAP咨询者,41例非咨询者和36例无腹痛症状的对照者及其母亲,所有被调查者完成问卷调查,问卷内容包括胃肠道及非胃肠道症状、学校缺勤率、心理学症状、心理应对、自尊心及对RAP的行为和认知反应。t检验结果显示,RAP组与对照组在以下方面存在显著性差异:①胃肠道及非胃肠道症状、学校缺勤率;②儿童的心理不良应激及消极应对;③母亲1BS严重程度、躯体症状及对RAP的恐惧。

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