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The results show that: This tablet can decrease the rat"s footpad swell induced by Freud"s, inhibit the permeability of the blood capillary in inflammatory joint and decrease the 11-2 level in serum while increasing the rat"s body weight,(2) It can lower the rat"s temperature and the permeability of the blood capillary in inflammatory joint induced by collagen and inhibit the delayed type hypersensitivity,It can lower the stickiness of full blood and the accumulation of erythrocyte obviously inblood stasis model rats,lt can inhibit the formation of hemolysin and decrease the index of carbon granule clearance in mice, It can lower the permeability of celiac blood capillary and inhibit the granulomatous hyperplasia by sc cotton ,It can inhibit the pain induced by acetic acid and raise the pain threshold value of heat stimulation.

结果表明:关络通片能明显降低佐剂性关节炎大鼠左右足趾肿胀度,降低大鼠炎症关节的通透性,抑制其IL-2含量,对大鼠体重增长缓慢有一定的改善作用;能改善Ⅱ型胶原诱导性关节炎大鼠的表征指标及炎症关节的通透性,对其迟发型超敏反应有一定的抑制作用;对血瘀模型大鼠,能显著性降低其全血粘度、血浆粘度、红细胞压积;能抑制小鼠的溶血素抗体生成,抑制小鼠网状内皮系统的吞噬能力,具有一定的抑制机体免疫功能的作用,能抑制小鼠腹腔毛细血管通透性增高,抑制大鼠棉球肉芽组织增生,具有一定的抗炎作用;能抑制小鼠醋酸扭体反应、提高小鼠热板痛阈值,具有一定的镇痛作用。

Beijingensis under three droughttreatments, normal, moderate and severe stresses. The results showed:(1) the canker disease ofboth cultivars was serious gradually with increased drought;(2) the bark tissue cells sufferedplasmolysis, more evident with the severity of drought stress;(3) under the drought andinoculation with B. dothidea, cells of two cultivars damaged at different degree, mailyrepresented in the changes of organelles, such as chloroplast swollen and distorted, number ofmitochondria increased and membrane system indistinct; then organelles suffered furtherdamagement with inoculation time, thinned mitochondrias stroma, decreased cristae, crumpledand partly broken membrane of chloroplasts with stroma exosmosis. At last, the chloroplastspartly disorganized;(4) the hyphae growed mainly intercellular in resistant cultivar and notonly intercellular but also intracellular in susceptible cultivar, which directly caused thenecrosis of cells;(5) under the severe drought, the damage of cells enhanced the infection ofpathogen and drought and pathogen stressed together and promoted the disease development;the damage from pathogen on cells was more serious than that from drought.

结果显示:(1)随着干旱胁迫程度的增加,2种杨树溃疡病害发生渐趋严重;(2)干旱胁迫下,杨树树皮组织细胞发生质壁分离,并随胁迫程度的增加而严重;(3)干旱胁迫下接种病原菌,2种杨树细胞发生不同程度的损伤,主要表现为细胞器发生较大变化,如出现叶绿体肿胀变形、线粒体数量增多,质膜模糊不清等现象;随接种时间的延长,细胞器受到进一步损伤,叶绿体被膜折皱,严重时局部破裂,基质外渗,并部分最终解体;(4)毛白杨中的菌丝主要在细胞间隙中穿行,而北京杨的菌丝除在细胞间隙中生长之外,侵入细胞内部也较多,直接导致细胞的解体;(5)干旱胁迫下细胞的损伤促进了病原菌的侵染,干旱和病原菌的双重胁迫加剧了病害的发生程度,并且病原菌侵染对细胞的破坏程度大于水分胁迫。

Results:(1) FSN can inhibit secondary joints swelling and multi-arthritis evidently, improve the whole condition of rats; at the same time, it can also lighten the synovial inflammation and hyperplasia of lesion joints distinctly, and prevent the joint cartilage and bone from destruction; the collective efficiency of FSN is better than TWP.(2) FSN can raise AA rats low LTT of spleen to normal nearly, remedy the disorder of Th / Ts and Thl / Th2 cells balance in peripheral blood, restrain exorbitant TNF- a ? IL-1 produced by PM O , thereof exert anti-inflammatory and immunoregulation effect.(3) Inside the lesion joints, FSN can depress abnormal hyper-expression of TNF- a mRNA and NF-kB in synovial tissues, as well as advance the expression of Caspase-3 (a proteolytic enzyme of apoptosis), reduce synovial immflamination and proliferation.(4) FSN can lower the expression of VEGF in synovial tissue,reduce neogenetic veins, so inhibit the growth of pannus tissue and the damage of cartilage and bone by that.(5) The above effect of FSN are in proportion to its dosage.Conclusions: FSN has inhibitory effects on symptom and condition of experimental RA, which is better than TWP as a whole.

结果:(1)FSN有明显的抗炎作用,可显著抑制AA大鼠足跖肿胀与多关节炎,改善大鼠的全身情况,同时明显减轻病变关节滑膜炎症与增生,防止关节软骨及骨质的破坏,其综合作用优于TWP;(2)FSN还能使AA大鼠低下的脾LTT恢复至接近正常,纠正外周血中T细胞亚群Th/Ts及Th1/Th2平衡紊乱,抑制大鼠PHφ过高的TNF-α、IL-1分泌,而发挥抗炎和免疫调节作用;(3)在病变关节局部,FSN能显著抑制AA大鼠滑膜细胞异常增高的TNF-αmRNA的表达,降低滑膜组织中NF-kB表达,并增加凋亡蛋白酶Caspase-3表达,从而抑制滑膜的炎症与增殖;(4)FSN还可下调滑膜组织中VEGF表达,减少血管新生,由此抑制血管翳的形成及其对软骨和软骨下骨的侵蚀;(5)FSN的上述作用皆呈现一定的量效依赖关系,高剂量组作用优于低剂量组。

FSN can raise AA rats low LTT of spleen to normal nearly, remedy the disorder of Th/Ts and Th1/Th2 cells balance in peripheral blood, restrain exorbitant TNF-α、IL-1 produced by PMφ, thereof exert anti-inflammatory and immunoregulation effect.(3) Inside the lesion joints, FSN can depress abnormal hyper-expression of TNF-αmRNA and NF-kB in synovial tissues, as well as advance the expression of Caspase-3 (a proteolytic enzyme of apoptosis), reduce synovial immflammation and proliferation.(4) FSN can lower the expression of VEGF in synovial tissue, reduce neogenetic veins, so inhibit the growth of pannus tissue and the damage of cartilage and bone by that.(5) The above effect of FSN are in proportion to its dosage. Conclusions: FSN has inhibitory effects on symptom and condition of experimental RA, which is better than TWP as a whole.

结果:(1)FSN有明显的抗炎作用,可显著抑制AA大鼠足跖肿胀与多关节炎,改善大鼠的全身情况,同时明显减轻病变关节滑膜炎症与增生,防止关节软骨及骨质的破坏,其综合作用优于TWP;(2)FSN还能使AA大鼠低下的脾LTT恢复至接近正常,纠正外周血中T细胞亚群Th/Ts及Th1/Th2平衡紊乱,抑制大鼠PMφ过高的TNF-α、IL-1分泌,而发挥抗炎和免疫调节作用;(3)在病变关节局部,FSN能显著抑制AA大鼠滑膜细胞异常增高的TNF-αmRNA的表达,降低滑膜组织中NF-kB表达,并增加凋亡蛋白酶Caspase-3表达,从而抑制滑膜的炎症与增殖;(4)FSN还可下调滑膜组织中VEGF表达,减少血管新生,由此抑制血管翳的形成及其对软骨和软骨下骨的侵蚀;(5)FSN的上述作用皆呈现一定的量效依赖关系,高剂量组作用优于低剂量组。

While the tissue spaces surrounding a few blood vessels wasAl and Fg positive,no Al or Fg positive cells were observed.In antemortem injurygroup,diffuse subarachnoid hemorrhage,cerebral edema,swelling or pyknotic neu-rons could be observed.The axons showed irregular swelling and disconnection at1~3h,marked swelling and disconnection at 6h,and retraction ball at 15h whichwas more remarkable at 24h after injury.The space between myelin sheaths andaxons was increased at 3~6h after injury.Tortuous and wavelike myelin sheathswhich adhered on axons incompletely,or even peeled off could be found from 15hto 24h after injury.Perinuclear lysis of Nissl bodies began at 24h after injury.Thenumber of GFAP positive cells in cerebrum and brain-stem increased significantlyfollowed by decrease,and then increased again,but the time courses of the changesin different areas of brain were not same.Al and Fg positive neural cells,mainlysurrounded blood vessels,with diffuse or peripherally distributed positive matter incytoplasm could be observed at 0.5h after injury.The number of Al or Fg positivecells and the intensity of immunoreaction increased with the time of injury.The areaof SYN positivity in medulla oblongata and pons decreased notably 3~6h afterinjury,then return to normal levels and continued to 24h after injury.

生前损伤组,可见广泛蛛网膜下腔出血,脑组织水肿,神经细胞肿胀,晚期神经元固缩;伤后1~3h见部分神经轴突不规则增粗、断裂,伤后6h断端膨大,伤后15h可见收缩球,至伤后24h更为明显;伤后3~6h可见部分神经髓鞘与轴突之间的间隙增宽,伤后15h髓鞘明显曲折,不完全附着在轴突两侧,甚至剥脱,持续到伤后24h;核周尼氏体减少在伤后24h才开始出现;同一部位的GFAP阳性细胞数目随损伤时间发生改变,先增多(最早在伤后0.5h),达到高峰后减少,其后又有增多趋势,但不同部位的GFAP阳性细胞数目增减的时间过程不尽相同,同时,大脑中的GFAP阳性细胞数目也有改变;伤后0.5h,可在脑干组织中见到Al和Fg阳性神经细胞,主要位于血管周围,阳性物在胞浆中呈弥散性分布,但部分细胞的阳性物仅分布于靠近胞膜的胞浆中而呈环状,随损伤时间延长,阳性细胞数目增多,反应强度增加;伤后3~6h,延髓及桥脑中的SYN阳性物面积减少,其后恢复到正常水平,并持续到伤后24h。

Observe the formula's effects to the diabetic nephropathy rat model cause by small dose STZ injured, high lipin feed and hemiresection, the results showed that can decrease significantly blood sugar after diet 2h, control availably hyperplasia of glomerulus mesenteric cell, inhibite tumefaction of glomerulus capillary endothelial cell, keep integrality of podocytic process and basement membrane, relieve vasal cavum stricture, reduce the GFR and excretory rate of 〓-MG, improve the status of high blood lipin, specially decrease significantly TC, reduce the 〓 and T/K, improve the status of microcirculation obstacle, elevate the activity of 〓-〓-ATP enzyme.

观察降糖益肾方对小剂量STZ诱导并单侧肾切除,高脂饲料喂养的糖尿病肾病大鼠模型的影响实验结果:对2h后血糖有显著降低作用(p.05),能有效抑制肾小球系膜基质的增生,减轻肾小球毛细血管内皮细胞肿胀,保持足突与基底膜的完整性,减轻血管腔狭窄,降低GFR、尿微量白蛋白以及〓-微球蛋白的排泄率(p.05),能改善高血脂状态,降低血TG、TC含量(p.05),降低〓与T/K比值(p.05),改善微血管循环障碍的状态;能升高肾组织中〓-〓-ATP酶的活性(p.05)。

Nursing care interventions offered included pain relief, physical therapy, and alternative therapies. We managed the problems of ineffective airway clearance due to the swelling of the larynx. Individualized wound care was provided for the patients to improve the noxious odor of the malignant fungated ulcerating wound. Through the nursing care the patient could actively participate in wound care, have better interaction with his family, and improve the disturbance of body image. During the process, we provided professional nursing care through listening, smiling, accompanying, and caring. Finally the patient could positively face the last course of his life. We combined the hospice care and assisted the patient and family to understand the meaning of hospice care. The patient was transferred to the hospice care unit and received continual care to promote his life quality at the terminal stage. At last, the young patient's life was ended peacefully without any regret. We expected to share these nursing care experiences with other nurse colleagues.

针对个案健康问题提出个别性、整体性之护理计画,包括协助个案减轻因肿瘤压迫带来的疼痛感;提供胸腔物理与其辅助疗法,处理因喉部肿胀致使痰液黏稠不易排出的问题;给予个别性伤口护理使能有效改善蕈状溃疡性伤口的恶臭,进而使个案愿意主动参与伤口照护并与家人有良性互动,以改善身体心像紊乱的问题;互动过程中以倾听、微笑、陪伴、关怀的护理美学与专业态度照顾个案及家属,而以正向态度面对生命最后一程;最后照会安宁共同照护,协助个案及家属了解安宁理念后,转入安宁病房接受癌末持续性照护,在生命最后阶段提升其生活品质,为年轻的生命划上无遗憾的句点。

A certain consumer segment has always been drawn toward more natural and healthy products, but with the volume of healthy-minded consumers swelling, the beverage segment has turned an attentive ear to the wants and needs of discerning shoppers in search of better-for-you drinks.

有一定的消费群体一直注意对自然和健康的产品,但随着数量的健康意识的消费者肿胀,饮料市场已成为一个倾听的欲望和需求的辨识购物者寻找更好的为您饮料。

Result: With a high cancer-inhibiting rate on the animal model having been transplanted the cancer, this medicine can remarkably restrain the growth of cancer cells cultivated in vitro and improve the life quality of mouse model, and also shows obvious promotion and enhancement function on the DTH ear-swelling of mouse with cancer, the proliferation of mouse spleen lymphocyte induced by ConA and the cytokine (TNF-α、IFN-γ) of mouse with cancer respectively. It can obviously decrease the adverse effects like weight reduction, damage of viscera and degradation of life quality caused by the chemotherapeutic medicines, and has a remarkable stimulation on the lymphocyte proliferation induced by ConA. It is also able to improve the ratio of SMMC-7721 cells in G0-G1 period and reduce the cell amount in G2/M period to cut down the possibility of stepping into the division period; additionally, it can obviously inhibit some cancer genes of the cancer cells and meanwhile up regulate the cancer-inhibiting gene.

结果:本品能明显抑制体外培养肿瘤细胞的生长,对在体肿瘤移植模型动物具有较高的抑瘤率,能明显提高模型小鼠的生存质量;对荷瘤小鼠DTH耳肿胀、ConA诱导的小鼠脾淋巴细胞增殖、荷瘤小鼠细胞因子(TNF-α、IFN-γ)呈现明显的促进或提高作用;能显著减少化疗药所引起的小鼠体重降低、脏器损害以及生存质量下降等不良作用;本品含药血清对ConA诱导的淋巴细胞增殖具有明显的促进作用;能提高SMMC-7721细胞G0-G1期比例,降低G2/M期细胞数目,而减少其进入分裂期;对肿瘤细胞的多个癌基因具有明显的抑制作用,同时上调抑癌基因等。

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With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务,乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐,因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。

Closes the eye, the deep breathing, all no longer are the dreams as if......

关闭眼睛,深呼吸,一切不再是梦想,犹如。。。。。。