肿瘤样的

There were 36 males and 40 females,with the average age of 47.7 years.36 patients presented with sciatica and perineal numbness,11 patients had painless mass and the other 20 were identified due to other causes.Among 67 benign neurogenic tumors,54 were originated from S1-S3 nerves,3 from S4-S5 nerves and 11 from the presacral space without caudal involvement.Giant cell tumor was found in 60 patients,which included 24 males and 36 females,with an average age of 32 years.Upper sacrum（S1-S2） was involved firstly.There were 56 patients（average,37.7 years） diagnosed as other primary benign bone tumors,which included 24 cases of teratomas,epidermoid cyst or dermoid cyst.Other malignant tumors,including chondrosarcoma （17）,Ewing′s sarcoma/PNET（14）,multiple myeloma（12）,lymphoma（6） and osteosarcoma（6） were found in 64 patients.

其中脊索瘤95例，男62例，女33例，平均年龄55.7岁，骶尾区疼痛是主要症状（82例），半数以上患者伴有坐骨神经痛，肿瘤多先累及低位骶骨（S3~S5）；神经源性肿瘤76例，男36例，女40例，平均年龄47.7岁，神经纤维瘤43例，神经鞘瘤24例，恶性神经鞘瘤9例，主诉多为坐骨神经痛、会阴部麻木（36例）和无痛性包块（11例），20例患者为查体或其他原因检查时发现，67例骶骨良性神经源性肿瘤起源于S3以上神经者54例，起源于S3以下神经者3例，发生于骶前未累及骶管者10例；骨巨细胞瘤60例，男24例，女36例，平均年龄32岁，腰骶尾部不适（37例）、坐骨神经痛（21例）是主要的临床表现，肿瘤多先累及上位骶骨（S1~S2）；骶骨其他原发良性肿瘤及瘤样病变56例，包括畸胎瘤、皮样囊肿、表皮样囊肿共24例；其他原发恶性肿瘤64例，包括软骨肉瘤17例，尤文肉瘤14例，多发性骨髓瘤12例，成骨肉瘤6例等。

Grossly, the tumors ranged from 0.7 to 17 cm, and exhibited a spongy or bubble wrap appearance reflecting the microscopic presence of variably sized cystically dilated tubules lined by a single layer of epithelium. The lining varied with a cuboidal, flat, and hobnail cell appearance, and the neoplastic cells had abundant eosinophilic cytoplasm and enlarged nuclei with prominent nucleoli.

大体上，肿瘤大小为0.7至17cm，海绵样或泡沫样外观，镜下观是大小不等的扩张成囊的管子，这些管子被覆单层上皮，上皮形态立方状、扁平状和鞋钉样，肿瘤细胞胞浆丰富、嗜酸，细胞核大，核仁明显。

As such, recognition of this entity is important in cases that show similar morphologic overlap with other chondroid/myxoid neoplasms that can arise within or near the central nervous system.

因此，认识这种肿瘤，并将其与之形态相似的、能发生在中枢神经系统内或附近的其他脊索样/黏液样肿瘤相鉴别，就显得十分重要。

The standard of the well contr ol of the disease included:(1) the ocular tumor shrank or even disappeared, and the tumor had creamlike changes or calcification and cicatrisation;(2) no oc u lar tumor recurrence in patients who had undergone enucleation;(3) no metastasi s found in the followup period.

病情得到良好控制的标准为：（1）眼部肿瘤缩小乃至消失，肿瘤病灶呈软乳酪样改变或出现钙化和瘢痕化；（2）眼球摘除者未出现眼眶肿瘤复发；（3）临床检查未见肿瘤转移。

To solve the problem and improve the safety of gene therapy, we used microencapsule, a insulation tool of cell transplantation immunity, to encapsule human fibroblastlike bone marrow stroma cells transfected by part of CEA gene and produced microencapsulated CEA transgeneic cell vaccines; we also studied the expression of vaccine in mouse body as well as its immunologic characteristics.

为解决上述问题、提高基因治疗的安全性，本研究采用细胞移植免疫用隔离工具-微胶囊包裹转染部分CEA基因的人成纤维样骨髓基质细胞HFCL，制备出CEA微囊化转基因细胞疫苗，并进行了疫苗在小鼠体内的表达及其免疫学性质的研究，探讨该疫苗应用于CEA阳性肿瘤治疗的可能性，并为进一步的临床应用研究奠定了基础。

Methods Nuclear β-catenin expression was detected by immunohistochemistry in 77 lesions with desmoid-type fibromatosis and 171 other spindle cell lesions, including superficial fibrmoatosis (n=18), nodular fasciitis (n=36), keloid (n=16), scar (n=10), granulation tissue (n=9), synovial sarcoma (n=38), neufibroma (n=13), solitary fibrous tumor (n=12), gastrointestinal stromal tumor (n=10), low-grade myxofibrosarcoma (n=3), low-grade fibromyxoid sarcoma (n=3), and smooth muscle tumor (n=10). In addition, the immunohistochemical expressions of ER-α, ER-β and Ki-67 were examined in all of the lesions with desmoid-type fibromatosis. The nuclear immunohistochemical staining for nuclear βcatenin and ER-β was graded as high level (≥25% of cells), low level (5%-25%) or none.

采用免疫组织化学染色法检测77例韧带样型纤维瘤病和171例其它良、恶性梭形细胞病变（包括结节性筋膜炎36例、浅部纤维瘤病11例、瘢痕疙瘩16例、增生性瘢痕10例、肉芽组织9例、滑膜肉瘤38例、神经纤维瘤13例、孤立性纤维性肿瘤12例、胃肠间质肿瘤10例、低度恶性黏液纤维肉瘤3例、低度恶性纤维黏液样肉瘤3例及平滑肌肿瘤10例）组织中β-catenin核阳性的表达，同时检测韧带样型纤维瘤病中ER-α、ER-β和Ki-67的表达。

Results CT showed a intrapelvic mass of rectal wall or surrounding soft tissue with inequality of size, relation closeness with intestinal wall; rectall wall different degree compression and narrowing,and extruding surrounding tissue.Below 5cm tumor density were slightly reduced,but symmetrical. Exceed 5cm tumor moderately enhanced, but asymmetrical. CT value of major mass were 25-35Hu, with boundary zone nodule enhancement, contrast-enhanced CT value 50-60Hu, and centricity necrosis.

结果 （1）盆腔内直肠壁或直肠周围软组织肿块，大小不等，肿块与直肠壁关系密切；（2）直肠不同程度的受压、变窄，肿块主要向直肠腔外生长，对周围组织产生推挤压迫；（3）径线在5cm以下肿瘤平扫时密度稍低，但均匀，增强时表现为中等度均匀强化，无坏死；径线在5cm以上10例肿块密度平扫时呈稍低密度且不均匀，CT值25-35Hu，增强时较大的肿瘤边缘带中等度结节样强化，CT值50-60Hu，肿块中心部分无强化，呈坏死样改变。

A cerebellar tumor like this, occurring in a 21 year old, generates a list of differential diagnosis that includes medulloblastoma (anaplastic or large cell variant), atyical rhabdoid/teratoid tumor, and less likely, choroid plexus carcinoma and metastasis.

发生于21岁男性小脑类似这样的病变，需要跟多种肿瘤鉴别，包括髓母细胞瘤，不典型畸胎瘤样/横纹肌样瘤，脉络丛癌以及转移性肿瘤等。

The mitotic count was higher than 5/50HPF in 5 cases in which the diameters of tumor were above or equal to 5 cm. Cystification, hemorrage or necrosis were found in 4 cases and mucification in 1 case. The mitotic count was 2-5/50HPF in 2 cases which were epithelioid cell and tumor diameter were 2-4 cm with mucification in 1 case.

核分裂像大于5/50HPF的5例中肿瘤直径均大于或等于5 cm，其中4例伴有囊性变、出血或坏死，1例伴有黏液样变。2例核分裂像在2~5/50HPF者均为上皮样细胞型，其中1例伴有黏液样变，肿瘤直径均2~4 cm。

Our research work investigated the possibility of applying the vaccine to gene therapy of CEA positive tumors and set the foundation for further study of its clinical application.

为解决上述问题、提高基因治疗的安全性，本研究采用细胞移植免疫用隔离工具-微胶囊包裹转染部分CEA基因的人成纤维样骨髓基质细胞HFCL，制备出CEA微囊化转基因细胞疫苗，并进行了疫苗在小鼠体内的表达及其免疫学性质的研究，探讨该疫苗应用于CEA阳性肿瘤治疗的可能性，并为进一步的临床应用研究奠定了基础。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。