肿瘤

The features of ultrasound image of adrenal cortex carcinoma were 1The tumor was big,mainly isoechogenic,more than 8.2cm in diameter;2The tumor shape was varied,irreqular or multilobar;3Color Doppler showed plenty blood supply of the tumor and its surroundings and 4Tumor necrosis frequently seen.

1。肾上腺皮质腺癌的声像图特征为：①肿瘤是以等回声为主的较大肿瘤，本组均大于8.2cm；②肿瘤形态多样，以不规则形及分叶状常见；③彩色多普勒血流显示瘤内及瘤周血流丰富；④肿瘤内多见液化坏死。2。

Result: A 77-year-old female presented at our hospital for blurred vision in her right eye. The intraocular pressure was 46 mmHg and slit lamp examination showed a protruding mass with papillomatous appearance near pupil margin. On chest X-ray examination, only prominent left hilum was noted. Iris tumor excisional biopsy was performed. Pathology investigation of the surgical specimen revealed carcinoma and immunohistochemical study demonstrated thyroid transcription factor-1 (TTF-1) positive. Chest-computed tomography showed left upper lung tumor and primary pulmonary adenocarcinoma was confirmed after CT-guided biopsy. She was placed under treatment with Genfitinib. Recurrent iris tumor mass was noted during follow-up, and chest CT revealed shrinkage of adenocarcinoma.

结果：一位七十七岁女性因右眼视力模糊至本院就诊，当时眼压为46毫米汞柱，细隙灯检查发现虹膜靠近瞳孔边缘有一乳突状肿块，胸部X光摄影仅见左肺门稍明显并未发现明显病灶，患者接受虹膜肿瘤切除手术，病理报告显示为恶性肿瘤，且免疫组织染色为thyroid transcription factor-l阳性，进一步的胸部电脑断层显示左上肺肿瘤，经电脑断层指引之切片检查证实为原发性肺腺癌，她接受Genfitinib药物治疗，后续追踪发现虹膜肿瘤复发，胸部电脑断层扫描显示肿瘤体积缩小。

Signalling through CXCR4 mediates actin polymerization and pseudopodia formation in cells, and induces chemotactic and migration to target organs. In addition, CXCR4-SDF-1 axis can promote tumor angiogenesis and growth.

CXCR4在肿瘤组织中的表达明显高于正常组织，而肿瘤常见转移部位均为CXCR4的配体基质细胞衍生因子-1(stromal cell derived factor-1，SDF-1)表达丰富的器官，SDF-1与CXCR4结合后可使细胞肌动蛋白丝聚合，形成伪足，从而定向诱导肿瘤细胞迁移到特定的靶器官；此外，CXCR4与其配体SDF-1相互作用可以促进局部新生血管作用，利于肿瘤生长。

Other patients has been observed for two years and none recure. Conclusions: Retroperitoneal laparoscopic adrenalectomy is a standard treatment of curing adrenal tumer. We must select the manner of adrenalectomy, according to the structure of adrenal and the character of tumor.

后腹腔镜下肾上腺肿瘤切除术是治疗肾上腺肿瘤的标准手术，术中应根据肾上腺本身结构及肿瘤的性质决定行肾上腺全切除或仅行肾上腺肿瘤切除术。

Results 5 cases of ependymocytoma, 3 cases of astrocytoma, 1 medulloblastoma hemangioblastoma in 10 cases of intra-medullary tumor; 36 cases of neurogenic tumor, 11 cases of spinal meningioma in 47 cases of subdural extramedullary tumor; 2 cases of neurogenic tumor strided over scleromeninx;2 cases of extradural metastatic tumor, 1 cestodiasis, 2 cases of epidural hematoma, which were mistaken for hemangioma before surgical operation and 1 vascular malformation in 4 cases of intraspinal nontumorous occupying lesion.

结果：10例髓内肿瘤中，室管膜瘤5例；星形细胞瘤3例；血管母细胞瘤1例；成神经管细胞瘤1例。47例脊髓外硬膜下肿瘤中，神经源性肿瘤36例；脊膜瘤11例。2例跨硬膜内外生长的神经源性肿瘤2例。硬膜外的转移瘤2例。4例椎管内非肿瘤性占位性病变中，椎管内绦虫病1例；硬膜外血肿2例，术前误为血管瘤；血管畸形1例。

Because of having tumor specificity, apoptin can be transferred enough to tumor-cell in vivo, selectly kill the tumor as a potential anti-tumor biological preparation.

根据凋亡素的肿瘤特异性，可将其作为一种极具潜力的杭肿瘤生物制剂，在人体内大量传递给肿瘤细胞，有选择性地根除肿瘤细胞。

Results:(1) The 90Y activity was higher while the contumination of 90Sr was less than 0.0031%;(2) The efficiency of 90Y-labeled antibodies was over 90%,the activity of labeled antibody maintained 82.3%;(3) Tumor size of all 90Y-antibody-treated model was significantly less than that of all 90Y-Cl3-treated model, the average survival time of the mice of the 90Y-antibody-treated group was significantly longer than that of the 90Y-Cl3-treated group;(4) In the tissue sections extensive necrosis was observed in all 90Y-antibody-treated tumor, the living tumor cells were immunohistochemically stainable with PcNA.

结果：(1)EDTA淋洗法制备90Y纯度高，其相对含量可达99.997％；(2)单克隆抗体的90Y标记率达90％以上，抗体蛋白活性保持82.3％；(3)治疗结果表明治疗组肿瘤明显小于对照组，原肿瘤的指数生长规律遭到破坏，治疗组生存期明显长于对照组；(4)组织学切片显示治疗组肿瘤有广泛坏死，PcNA免疫组化显示治疗组肿瘤细胞增殖受到明显抑制。

In order to settle such predicament, the author put forward a new idea that research of TCM may be carried out as Systems biology. To take tumor as an example, tumors occur, then develop into a big one, during which experiences a multifactorial 、multifactorial processes, so Tumor Systems biology typifies holistic、kinetic、stratose and integrate characters.

文章以肿瘤系统生物学的研究思路与中医肿瘤学理论的结合点为线索，从肿瘤的发生、中医的调整阴阳的治则、现代医学的靶向治疗及肿瘤诊治的医学信息等方面为切入点对肿瘤系统生物学建立及其与中医理论结合的可行性与必要性作一初步探讨。

These results indiacated that tranferring macrophages combinedwith cytokines could be a new adoptive immunotherapy protocol foradvanced cancer,and rTNF used in vivo locally could induce andactivate macrophages to kill tumor cells.Monocytes when activatedunderwent a series of phenotypic and functional changes includingthe expression of IL-2R which may provide an important immunoregu-latory pathway.The presence of lectin-like molecules on thesurface of monocytes and tumor cells may bring theeffector/target cells together,thus facilitating the inductionof apoptosis in target cells by triggering the production ofcytolytic factors and the modification of target of targer cell surface anti-gens.(such as HLA-DR).

综合以上结果可以得出以下结论：转输巨噬细胞并结合细胞因子的联合应用是肿瘤继承性免疫中的又一新的、有潜力的方法；抗肿瘤细胞因子rTNF可通过激活巨噬细胞在体内抑制对其不敏感的肿瘤细胞的生长；人单核细胞在一定条件下激活后，可表达IL-2R，进而一方面增强其自身对IL-2的敏感性，另一方面在体内也具有调节T细胞功能的作用；单核细胞和肿瘤细胞上存在的凝集素类受体可促使两种细胞之间在凝集素介导下相互接近，并诱发单核细胞产生细胞毒因子，以及通过调节靶细胞上表面抗原的表达，促进诱导靶细胞的细胞凋亡。

Tumor incidence and tumor weight , defined as the weight of the tumored bladder , were determined on day 6 and 10 after GCV intraperitoneal injection for 6 days .

肿瘤生长情况观察：治疗前后，膀胱肿瘤超声检查大小，及以称量膀胱总重量作为肿瘤发生率、肿瘤大小的指标。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。