肿瘤

Hypoxia induces the resistance of tumor cells[4];and the heterogeny of solid tumors result in the appearance of subpopulations of differentproliferative potency in the same tumor tissue, so that the target cells sensitive to cell cyclespecific drug are reduced.

目前有研究认为：实体瘤部分细胞缺氧和肿瘤组织的异质性可能是导致肿瘤对放疗和化疗产生耐受的主要原因之一，缺氧可以诱导肿瘤细胞对放疗和化疗的耐受性[4]，实体肿瘤的异质性可使同一瘤组织内具有不同增殖潜能的癌细胞亚群存在，导致细胞周期特异性化疗药物作用的靶细胞减少。

Genesis,development and metabasis of solid tumor have close relationship with tumor vessel angiogenesis; extracellular matrix degradation is the key point for tumorous infiltration and metabasis;the significant biology characteristic of tumor cell is the disorder of tumor cell differentiation and apoptosis.

骨巨细胞瘤血管生成是近年来研究热点，实体瘤的发生、发展及转移与肿瘤的血管生成密切相关；细胞外基质降解在肿瘤的浸润和转移中起到关键作用；肿瘤细胞的分化凋亡障碍与无限增殖能力是肿瘤细胞的重要生物学特征。

It was demonstrated in the ECG as follows:① most tumors developed in left atrium, few in right atrium and infrequent in both atriums;②most tumors in left atrium were myxoma, of which the appearance is simple in ECG image.

左房肿瘤以粘液瘤多见，ECG图像表现单一，其它肿瘤少见；右房肿瘤虽然少见，但肿瘤病理类型多，ECG图像特征多样。

1With the increasing of the diameter of microvessel and width of tumor trabecular,the size of tumor has the tendency of increasing.(2) The MVD of the HCC having satellitic nubble and having lower differentiation degrees were higher,and the microvessels width of tumor were bigger.

1HCC肿块大小与肿瘤MVD相关，与肿瘤微血管直径和肿瘤梁索直径呈正相关趋势；(2)有卫星结节、低分化HCC的MVD较高，肿瘤微血管直径较大；(3)有门脉癌栓的HCC的MVD较高。

Correlation of histotypes of phyllode tumor with local recurrence and tumor death was statistically significant at a level of P＜0. 001; correlation of infiltrative growth of the tumor with local recurrence was statistically significant at a level of P＜0. 001. Tumor necrosis and mitotic activity were independent prognostic factors.

叶状肿瘤的病理组织学等级与肿瘤的局部复发和因瘤死亡有统计学线性关系(P＜0.01)；肿瘤的浸润性生长方式与肿瘤的复发有线性关系(P＜0.01)；肿瘤性坏死和核分裂数值是独立的预后因素；术式等11个临床病理因素为单风险预后因素。

Based on our experiences, we conclude that: 1 rhabdomyoma is the most common primary cardiac tumor in children; 2 most pediatric tumors are associated with tuberous sclerosis; 3 clinical presentation is determined by the tumor size and number of tumors, and whether expansion of the malignancy has resulted in cardiac blood-flow obstruction; 4 there is a strong possibility of regression of the primary cardiac tumor, with surgery recommended only when cardiac symptoms are severe; and, 5 unless there is a significant obstruction of blood flow, chemotherapy is still the treatment of choice for secondary cardiac tumors.

根据我们的经验，我们认为(1)横纹肌瘤是儿童最常见的心臓肿瘤，(2)临床表现的严重度取决於肿瘤的大小，数目以及是否占满了心臓腔室而有血流阻塞的现象，(4)在原发性肿瘤中是有机会自发性的变小，而且除非有严重的心臓症状，否则并不建议开刀，(5)在次发性肿瘤中化学治疗仍然是治疗上的首选，除非有血流阻塞的现象。

With a persisting development in tumor targeting viruses as a special anti-tumor agent and therapeutic gene vector for the recent years, a number of highly effective, targeting virus vectors have been exploited, which still did not satisfy the requirement for cancer targeting therapy in clinic. However, it has remained unsolved in how to effectively and veraciously deliver these targeting viruses to the tumor tissues.

肿瘤靶向性病毒作为一种特殊的肿瘤治疗药物和基因治疗载体近年来已得到长足发展，许多高效、靶向性病毒载体已被相继研究开发，但仍不能满足临床上肿瘤靶向治疗的需要，如何将这些靶向病毒准确而高效地运输到肿瘤病变部位仍然未得到充分解决。

On the other hand, ectopic expression of constitutively active AKT greatly reduced apoptosis induced by Tid1 overexpression.

此外，在肿瘤细胞族群中，只有少数的肿瘤异质化族群具有肿瘤起始能力称为肿瘤干细胞。

The standard of the well contr ol of the disease included:(1) the ocular tumor shrank or even disappeared, and the tumor had creamlike changes or calcification and cicatrisation;(2) no oc u lar tumor recurrence in patients who had undergone enucleation;(3) no metastasi s found in the followup period.

病情得到良好控制的标准为：（1）眼部肿瘤缩小乃至消失，肿瘤病灶呈软乳酪样改变或出现钙化和瘢痕化；（2）眼球摘除者未出现眼眶肿瘤复发；（3）临床检查未见肿瘤转移。

objective:our aim is to investigate the relationship of vegf c,vegf d and lymph node metastasis in pancreatic cancer,and to elucidate the role and significance of the cancerous peripheral lymphatic tissue.methods: the expression of vegf c and vegf d was assayed by means of immunohistochemistry in 30 pancreatic carcinomas.results:the positive rates of vegf c、vegf d were 73%(22/30)、57%(17/30) respectively in pancreatic cancer.the expression of vegf c、 vegf d in cancerous invasive edge was significantly higher than that in the center of cancerous tissues.there was no correlation between the expression of vegf c、vegf dand the site,differentiation,histology types.

目的：探讨胰腺癌中vegf c、vegf d蛋白表达与淋巴结转移之间的相关关系，阐明癌周淋巴管增生在胰腺癌淋巴转移中的作用及意义。方法：免疫组化检测30例胰腺癌组织中vegf c、vegf d的表达及其与临床病理、淋巴结转移的关系。结果：胰腺癌vegf c、vegf d蛋白表达阳性率分别为73%(22/30)、57%（17/30），肿瘤周边部位显著高于肿瘤中心部位，其表达与肿瘤的部位、分化程度、组织学类型无关，与肿瘤的tnm分期有关，ⅲ~ⅳ期显著高于ⅰ~ⅱ期。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。