肿瘤

All 5 patients of benign polyp were found to have excellent effect after Nd-YAG laser therapy, and so for, there was no recurrence. Two (esophageal cancer 1 and rectal cancer 1) of 19 patients of G-I cancer had excellent results with tumor size reduced over 90% and endoscope could pass through the stenotic area smoothly after Nd-YAG laser treatment. Six (esophageal cancer 2, gastric cancer 4) of them had good results with tumor size reduced 50-90% and patient could take semiliquid food after laser management. Eight patients (esophageal cancer 2, gastric cancer 4, rectal cancer 2) had fair effects with tumor size reduced less than 50%, but the oral intake or stool passage was improved. Three patients (15.8%) refused further endoscopy and laser management because of poor tolerance.

这5例良性息肉经雷射治疗后，肿瘤完全消失且目前无后发现象。19位恶性癌中，经Nd-YAG雷射治疗后，效果极佳（肿瘤大小减少90%以上，内视镜可通过肿瘤狭窄处）者2例（食道癌及直肠癌各1；效果佳（肿瘤大小减少50~90%，且病人可进食半流体食物）者6例（食道癌2，胃癌4）；效果尚可（肿瘤大小减少50%以下，但饮食进步或排便较过去进步）者8例（食道癌2，胃癌4，直肠癌2；3例患者(15.8%)因不能忍受内视镜及雷射治疗之痛苦，拒绝进一步的治疗而失败。

Method］twelve cases with extremities invasion bone tumor were reviewed,including 6 male and 6 female.the average age was 37.1 years old.according to the mri,typeⅰtumor located in metaphysic and growth eccentricity,and was treated with outside tumor osteotomy with reservation of one side as integumentale,the cut line was shape of "匚".type ⅱ tumor was with invasion part articular surface,and was operated with part joint osteotomy with reservation of one side as integumentale,the cut line was shape of"l".type ⅲ was with invasion total joint surface and as integmentale,all tumor segment including joint could be cut,but the shape of cut close to the diaphysis was echelonment.

方法］12例侵袭性骨肿瘤患者男6例，女6例；平均年龄37.1岁。根据mri表现选择不同截骨方法，ⅰ型肿瘤位于干骺端偏心性生长，采用保留一侧皮质骨的肿瘤外截骨，截骨线呈&匚&形。ⅱ型病例肿瘤侵蚀部分关节面，采用保留一侧皮质的部分关节截骨，截骨线呈&l&形。ⅲ型病例肿瘤侵蚀整个关节面和骨皮质，可切除包括关节在内的整个瘤段骨，只是近骨干侧截骨呈阶梯状。

Results:17 rats were confirmed successful transplantation by MRI,the capacity of the tumor was 88.40±7.62mm3 on 8th day, 986.80±114.46mm3 on 16th day,the volume growth was 8-12 folds;on 8th day following transplantation,the tumor tissue was gray in color with fish homogen state without interior necrosis, the tumor cells were nest-distributed by HE staining,large dense staining of nucleus with manifest heteromorphism,tumor microvessel count increased by immunohistochemistry with buffy yellow staining, VEGF high expressed in the tumor cells with buffy yellow granule shape.

结果：17只大鼠经MRI检查证实均种植成功，肿瘤体积第8天为88.40±7.62mm3，第16天为986.80±114.46mm3，体积增长8-12倍之间；种植第8天，肿瘤组织呈灰白色、鱼肉均质状，内部未见坏死，HE染色肿瘤细胞呈巢状分布，胞核大浓染，异型性明显；免疫组织化学示肿瘤微血管数目较多，呈棕黄色染色，肿瘤细胞VEGF高表达，呈棕黄色细颗粒状。

Cancer-Testis antigens are specifically expressed in various types of human tumors but not in normal tissues except for testis. Among the CT antigens, NY-ESO-1 is the most immunogenically identified so far.

肿瘤免疫治疗，由于其具有抑制肿瘤细胞生长、杀灭残存肿瘤细胞和微转移灶的功效，因此辅助手术和化疗进行的肿瘤免疫治疗有可能成为肿瘤治疗中一个新的热点。

The mRNA expression of MMP-2 in more than 4 lymphnodes positive is lower than in lymphnode 1-3 positive （P＜0.05）.The MMP-2 mRNA expression is irrelated with tissue grade,pathologic type,ER,PR and Her-2.Conclusion MMP-2 mRNA expression is upregulated in early clinical stage,lymph node metastatic early stage,and down regulated with tumor progressing.MMP-2 mRNA expression is related with the metastasis of breast cancer.

MMP-2 mRNA转录水平的表达与乳腺癌转移有关，MMP-2在转录水平的表达在肿瘤较小时上调，随着肿瘤的增其转录水平表达下调，随着肿瘤恶性程度的增加，其转录水平的表达量在下降，在肿瘤发生的早期表达上调，随着肿瘤的进展表达量下调。

The best quality of MRS is that the MRS is the only noninvasive and in vivo means in detecting the changes in metabolism state and special biochemical compounds in living animal and human body, and that make it possible for us to observe the physiological and biochemical characteristic of brain neoplasma ,and the development of neoplasma.

脑肿瘤是较为常见的肿瘤，其发病率占全身肿瘤的1.8％，其中以脑胶质瘤为最多，占43.7％，脑肿瘤的诊断及治疗一直是临床及基础研究的难点及热点，为了更好的了解胶质瘤的生物学特征，寻找有效的治疗方法，人们一直在寻求建立稳定安全的脑动物模型，大鼠C6胶质瘤具有与人脑胶质瘤相似的生物学特征，且模型较为稳定，被广泛用于肿瘤生物学及实验性治疗的研究中。

Methods:Human CD80 cDNA was transfected into B16 melanoma cells by lipofectin-mediated gene transfer before the expansion of tumor cells were tested by MTT method in vitro;C57BL/6 mice were inculated subcutaneously either mock-transfected B16 cells (B16-neo)or CD80-transfected B16 cells (B16-CD80),then the latency,survival times and tumor mass growth were investigated.The lymphocytes were examined for both proliferation indices and specific cytotoxic activity by MTT method and improved LDH-releasing method,after syngenic Mixed Lymphocyte tumor cultures.

通过脂质体介导将CD80基因导入小鼠黑色素瘤B16细胞后，利用SABC法检测CD80的表达；MTT法测定肿瘤细胞体外增殖能力；将肿瘤细胞接种至同源小鼠皮下后观察成瘤期、荷瘤小鼠存活期及肿瘤结节生长速度；在同源淋巴细胞肿瘤细胞混合培养后，通过测定淋巴细胞增殖指数和CTL杀伤活性检测肿瘤细胞的免疫原性。

Tuberculum sellae meningiomas can be removed completely and safely with higher total resection rate, less postoperative complications and better operative results in majority of cases.

结论大多数鞍结节脑膜瘤可以完全及安全地切除，小、中型肿瘤宜采用眶上匙孔入路，中、大型肿瘤宜采用单侧额下或翼点侧裂入路，大型肿瘤或侵犯肿瘤视神经管者宜采用眶颧入路切除肿瘤。

Comparison of recurrent tumors at the time of the primary diagnosis and of recurrence showed that histologic subtype and grade were identical in 76% of the cases and converted to a higher grade tumor in 24% of the cases, especially, in patients treated with local excisions and circumcisions.

复发性患者的首发肿瘤与复发肿瘤相较，其中76%患者两次肿瘤的组织学亚型和级别相同，另外24%患者复发的肿瘤进展至更高级别，尤其是那些接受肿瘤局部切除加包皮环切的患者。

The rationals of anti-angiogenesis are the following: the therapeutic target is tumor endothelial cells which are more genetically stable, more homogeneous, and with lower mutation rate; the anti-angiogenesis drugs can contact endothelial cells directly, with higher potency and lower drug barriers and side effects; the aim of anti-angiogenesis therapy is to block the oxygen and nutrition supply from vessels, instead of killing tumor r ells per se; the aim of anti-angiogenesis is to reduce tumor size instead of eradicate tumor which are different from traditional chemotherapy.

使用抗血管新生疗法根据的理论基础为以肿瘤血管的内皮细胞为治疗药物的攻击标的；肿瘤血管的内皮细胞基因比较稳定、同质性高、而且突变率低；投与的药物可以直接接触内皮细胞，减少投与药物屏障，因此增加有效投与药物的能力及减少药物副作用；以截断供应肿瘤氧气养分的血管为目标：以减小肿瘤的体积大小为目的，与传统化学疗法以根除肿瘤的目标不同。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。