肿瘤

Tumor associated protein N35 was located on the centriole of the chromosomal domain at the S-G2 phage.Conclusions The tumor associated protein N35 might be a tumor cell growth regulator, expressed only it's the cancer cells and related with the proliferation of cancer cells. It is one of tumor markers.

肿瘤相关蛋白N35可能是一种只存在于肿瘤细胞并与其增殖活动密切相关的重要的肿瘤细胞生长调节蛋白，其功能可能与肿瘤细胞无限制增殖活动有关，是肿瘤标志物之一。

During the curing process, first,to inject the Harmony No.1 at focus of patient directly to let medicine go inside of tumour, and after 24hours, the medicine will damage and dissolve the tumour cells; second, prick the area has been injected and make it as cinquefoil, use minus-pressure puller to drain gore of dead tumour cell out of body; third,to inject Harmony No.1 at focus again, then inject in mainline to clear virus and tumour cells haven't been formed in blood.

在对病人治疗过程，首先对肿瘤癌症病灶部位直接注射和谐一号核子注射液，使药物直接进入肿瘤内部，经过24小时药物对肿瘤细胞的杀死破坏及溶解；第二步，对注射处扎针，使其呈梅花状，用负压吸引器把含有坏死肿瘤细胞的瘀血排出体外；第三步，给病人病灶部位注射和谐一号注射液，再对病人注射静脉针液，用来清除血液中的病菌病毒及杀死血液中未形成的肿瘤细胞。

How to induce apoptosis in these never-die cell in order to cure cancer is the consistency principle of the cancer researchers.

肿瘤耐药的研究一直是肿瘤研究的热点问题，如何让这些不可死亡的肿瘤细胞发生凋亡而最终达到治愈肿瘤的目的是研究肿瘤耐药的学者们一贯的思路。

Giant cell tumor of bone is a kind of common bone tumor,which has characteristics of high recurrence rate and invasion.recently,tumor vessel angiogenesis has been the warm spot of research.genesis,development and metabasis of solid tumor have close relationship with tumor vessel angiogenesis; extracellular matrix degradation is the key point for tumorous infiltration and metabasis;the significant biology characteristic of tumor cell is the disorder of tumor cell differentiation and apoptosis.the correlated research has very important significance for judging gct prognosis and guiding therapy.

骨巨细胞瘤（giant cell tumor of bone，gct）是一种常见骨肿瘤，由于其高复发率和强侵袭性，备受临床骨科工作者的关注。骨巨细胞瘤血管生成是近年来研究热点，实体瘤的发生、发展及转移与肿瘤的血管生成密切相关；细胞外基质降解在肿瘤的浸润和转移中起到关键作用；肿瘤细胞的分化凋亡障碍与无限增殖能力是肿瘤细胞的重要生物学特征。骨巨细胞瘤生物大分子研究的不断深化对判断gct的预后及指导治疗有重要意义。

Comparison of recurrent and nonrecurrent tumors showed that high grade tumors tended to be significantly associated with recurrent tumors, whereas low grade variants were more frequent in the nonrecurrent group; recurrent tumors invaded into deeper anatomic levels than nonrecurrent tumors.

复发性肿瘤与非复发者相较，高级别肿瘤与复发显著相关，而低级别肿瘤更易出现在非复发组中；复发性肿瘤浸润正常组织的深度大于非复发性肿瘤。

objective to observe the antitumor activities of different solution extracts of plumbago zeylanica l.in vitro.method mtt method was used to detect the inhibitory effects on four kinds of cancer cells.results chloroform extracts had significant inhibitory effects on the breast cancer cell(bre-04),the nerve cancer cell(n-04) and the lung cancer cell(lu-04),ic50 were 0.2699mg/ml and 0.2634mg/ml,0.4961mg/ml respectively.ic50 of chloroform extract on the hepg2 was 0.9379mg/ml.ic50 of petroleum ether extracts on bre-04,n-04,lu-04 and hepg2 was 0.5902mg/ml,0.5725mg/ml,0.7938mg/ml,0.6374mg/ml;ethyl acetate extracts had fairly inhibitory effects on the lu-04,ic50 was 0.7343mg/ml;n-butanol extracts and water-solubility extracts had notsignificant inhibitory effects on the four kinds of cancer cells.conclusion the antineoplastic effective parts of plumbago zeylanica l.were chloroform and petroleum ether extracts.

目的 探讨白花丹体外抗肿瘤作用的活性部位。方法 mtt染色法对白花丹五种溶剂提取物体外抗肿瘤活性进行了初步的研究。结果氯仿提取物对乳腺癌细胞（bre-04）、神经癌细胞（n-04）、肺癌细胞（lu-04）有较好的抑制生长作用，ic50分别为0.269 9 mg/ml、0.263 4 mg/ml、0.496 1 mg/ml，对肝癌细胞hepg2抑制作用差， ic50为0.937 9 mg/ml；白花丹石油醚提取部位对乳腺癌细胞（bre-04）、神经癌细胞（n-04）、肺癌细胞（lu-04）、肝癌细胞hepg2的ic50分别为0.590 2 mg/ml、0.572 5 mg/ml、0.793 8 mg/ml、0.637 4 mg/ml；乙酸乙酯提取物对肺癌细胞（lu-04）有一定的抑制作用，ic50为0.734 3 mg/ml；水溶性提取物以及正丁醇提取物无明显抑制肿瘤作用。结论白花丹氯仿提取部位、石油醚提取部位体外抗肿瘤作用较好，值得对其提取部位进一步分离纯化并研究其抗肿瘤作用机制。

Nephrometry Score consists ofadius,xophytic/endophytic properties of the tumor,earness of tumor deepest portion to the collecting system or sinus,nterior/posterior descriptor and theocation relative to the polar line.

结果：肾脏散色比浊法评分由下列部分组成：半径（以肿瘤最大直径作为衡量肿瘤大小的依据），肿瘤的外生/内生特性，与肿瘤最深处接近肾集合系统或肾窦的距离，对肿瘤前方/后方部位的描述以及与极线相关的定位。

Recently the traditional cancer therapies were realized to be lack of selectiveness and efficiency,as a result the targeted anti-cancer therapies have been studied as a new way.In this review gene therapy of cancer which is selective and oncolytic virus and the problems lie in which were introduced.

肿瘤是类严重危害人类健康的疾病，然而传统的治疗手段因缺乏靶向性，不能达到良好的抗肿瘤效果，因而靶向性抗肿瘤疗法成攻克肿瘤的新的发展方向本文对肿瘤的靶向性基因治疗和溶癌病毒的研究进展及其存在的问题做一阐述。

mitochondrial dnais the only inheritant substance except for the nuclear dna in a euˉkaryon cell,which is related to the oxidative phosphorylation of a cell.mitochondrial dna is the important target of carcinogens and is vulnerable because of its structure and function.the mutation of mtdna could reduce the nomal respitation and release large quantities of ros,whichincrease the danger of cancer happening.so,mtdna has been thought to be involved in carcinogenesis and recently more and more studies in this aspect have comeout.in this paˉper,we review the researches for relationship among mtdna mutation and tumors in digestion system,woman system,head and neck,urinary systemand blood system.

线粒体dna（mitochondrial dna，mt dna）是真核细胞中唯一存在的独立于核dna之外的遗传物质，与细胞的氧化磷酸化功能密切相关。mtdna自身的结构和功能特点决定了它是致癌物作用的重要靶点，易受致癌因素的损伤而发生突变。mtdna的突变可削弱正常的呼吸功能，释放高水平的活性氧，进而增加肿瘤发生的危险性，所以mtdna被认为与肿瘤发生有密切关系。近年来，这方面的研究越来越多，本文现就mtdna突变与消化系统肿瘤、妇科肿瘤、头颈部肿瘤、泌尿系统肿瘤等实体瘤以及血液系统恶性肿瘤之间的关系作一简单的综述。

Vulvae tumor, vagina tumor, womb tumor, ovary tumor, oviduct tumor and other diseases will have adversely affect women' health and may even threaten their lives.

外阴肿瘤、阴道肿瘤、子宫肿瘤、卵巢肿瘤、输卵管肿瘤等疾病，对女性身体乃至生命影响极大，防止肿瘤侵害，必须预防。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。