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肿瘤

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As the exosomes are derived from tumor cells, carry tumor antigens and share characters with most of the vaccines prepared previously, they are a kind of noncellular novel vaccine.

由于这种EXOSOME来自于肿瘤细胞,携带有肿瘤抗原,又有几乎所有目前研制的高效肿瘤疫苗所必须的公刺激信号的特性,强烈提示这是一种非细胞性的新型疫苗。

We study the expression levels of GLUT1 in 16 samples of esophageal cancer and their normal mucosa by reverse transcriptasepolymerase chain reaction and immunohistochemical staining, analyse the correlation between the expression level of GLUT1 mRNA and protein in the tumor cells. Then we study the expression levels of GLUT1 in 55 patients with esophageal cancer by immnohistochemical staining, analyse the relationship between GLUT1 expression and clinical features of the patients.

我们采用逆转录聚合酶链反应和免疫组化染色的方法,研究GLUT1 mRNA及蛋白在16例食管癌病人的肿瘤组织和相应正常食管粘膜的表达水平,同时分析食管癌组织中GLUT1在mRNA水平和蛋白水平表达的相关性;采用免疫组化染色的方法研究55例食管癌病人肿瘤标本的GLUT1表达水平,并分析其与肿瘤的临床特性及预后的关系。

The journal publishes reviews covers the whole field of the biology and biochemistry of cancer, emphasizing oncogenes and tumor suppressor genes, growth-related cell cycle control signalling, carcinogenesis mechanisms, cell transformation, immunologic control mechanisms, genetics of human cancer, control of cell proliferation, genetic and molecular control of organismic development, rational anti-tumor drug design.

该杂志主要发表有关肿瘤生物学和生物化学的综述。其内容包括:致癌基因和肿瘤抑制基因,与生长有关的细胞周期控制的信号转导,致癌机理,细胞转化,免疫控制机理,人类癌症遗传学,细胞增殖的控制,组织发育的遗传和分子控制,合理的抗肿瘤药物设计等。

"Learning more about the way a specific type of cancer deelops, and what proteins it produces as it grows, helps us find better ways to treat that cancer," said Dr. Lai, who is a cancer researcher at Mayo Clinic with background as an otolaryngologist."With nasopharyngeal cancer, we think this new enzyme may help sole the puzzle."

"了解更多的有关特定肿瘤发育过程的知识,以及其生长过程中产生的蛋白质,能够帮助我们找到更好的治疗肿瘤的办法,"具有耳鼻喉科医师身份,目前作为肿瘤科研人员工作在Mayo临床中心工作的Lai博士说:"对于鼻咽癌,我们认为这种新的酶能够解决这些难题。"

Allabove indicated that the more antitumor ability of PELs was not theirmount,perhaps,but their quality.

以上这些说明微环境中一定水平IL-2的存在能使肿瘤的细胞免疫应答速度加快,免疫细胞获得杀伤能力所需时间短并伤百分率高,从而使在这种微环境中肿瘤细胞的生长明显受到抑制,同时也说明mIL-2〓诱导的PEL抗肿瘤能力,并非是通过免疫细胞数量上的增加来实现。

The results indicated that after B16 and mIL-2+B16 cells inoculatingperitoneal cavity of C57BL/6 respectively,1on 1,3,6,days therewere nothing in peritoneal cavity of C57BL/6 which inoculated mIL-2+B16 cells,however on sixth day,there were distinct tumor tissuein peritoneal cavity of C57BL/6 which inoculated B16 cells.2Therewere different mount of PELs induced by mIL-2+B16 or B16 cellsrespectively.

在将〓与mIL-2〓细胞分别植入C57BL/6腹腔后,于第1,3,6天时观察其腹腔中的肿瘤生长情况,mIL-2〓一直到第6天时肉眼见不到任何肿瘤组织,而〓在第6天时,在腹腔中可以肉眼见到十分明显的黑色肿瘤组织。2.mIL-2〓和〓在小鼠腹腔中诱导免疫应答的数量水平也不同,平均每只小鼠的〓PEL数从第1天的0.75〓到第6天的2.67〓呈逐步上升趋势,每只小鼠的mIL-〓PEL数从第1天的1.13〓到第2天的2.5〓〓,而到第6天却降至2.23〓。3。

Both benign and malignant endocrine neoplasms demonstrate some degree of cellular pleomorphism, so it is not easy to tell benign from malignant on histologic grounds alone.

无论是良性内分泌肿瘤还是恶性内分泌肿瘤都显示一定程度的细胞异型性,因此仅从组织学上很难区分肿瘤的良恶性。

RESULTS: Of 233 patients, 217 (93%) never required surgical palliation of their primary tumor. Sixteen patients (7%) required emergent surgery for primary tumor obstruction or perforation, 10 patients (4%) required nonoperative intervention, and 213 (89%) never required any direct symptomatic management for their intact primary tumor.

结果:在这233名患者中,217(93%)名患者由始至终不需行原发性肿瘤姑息手术。16名(7%)患者由于原发性肿瘤阻塞或穿孔需行急诊手术,10名(4%)患者需行非手术治疗,213名(89%)患者从来不需对完整的原发性肿瘤采取任何对症治疗措施。

In this system, the consistencies of nutrition and restrainer satisfied two elliptic equations, but the tumor growth satisfied the Stefan condition on the boundary of the tumor field.

在这个问题中,肿瘤生长环境内部的营养物、抑制物浓度分别满足两个椭圆型方程,但是在肿瘤的边缘——该问题的自由边界,肿瘤的生长状态满足Stefan条件。

Methods After having successfully duplicated the animal models of Wistar rats bearing C6 glioma, we assigned the rats stochastically into three groups and gave each group different treatment respectively. The growth status of tumor, the pathohistological and ultrastructural changes were detected, so was the salic acid of rat's serum.

方法构建荷C6肢质瘤Wistar大鼠的肿瘤模型,随机分组给予不同的处理给药,观察治疗期间及治疗后的肿瘤生长情况,通过病理组织学、超微结构分析及大鼠血清唾液酸含量的测走,检测新城疫病毒HN基因核酸疫苗在Wistar大鼠体内的抗肿瘤作用。

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