肿瘤

Aim To study the expression of CD44V6 and Cathepsin D in early and advanced gastric carcinomas, and their prognostic significances.

肿瘤的侵袭和有无淋巴结转移是恶性肿瘤致患者死亡的主要原因，探讨能评估肿瘤转移的指标，是研究肿瘤预后的关键。

The tumor stem cell theory provide a new way for the mechanism and therapy study of tumor.

目前已有多种证据支持肿瘤的干细胞起源，肿瘤干细胞理论为肿瘤的发生机制及治疗提供了新的方向。

Many evidence suppport that tumor is origin from the stem cell .The tumor stem cell theory provide a new way for the mechanism and therapy study of tumor.

目前已有多种证据支持肿瘤的干细胞起源，肿瘤干细胞理论为肿瘤的发生机制及治疗提供了新的方向。

Resulte: In 12 infective lesions, including purulent infection (4 cases) and tuberculosis (8 cases), the correct dignosis was made in 4cases by CR and in 11 cases by CT. In 16 soft tissue tumors, including lipoma (7 cases), fibrosarcoma (4 cases), hemangioma (1 case), neurofibroma (1 case), malignant fibrous histocytoma (1case), aggressive fibromatosis (1 case) and liposarcoma (1 case), the correct diagnosis was made in 3cases by CR and in 14 cases by CT. In 11 bone lesions, including fibrous dysplasia (7 cases), chondroma (2 cases), myeloma and cosinophilic granuloma (1 case), the correct diagnosis was made in 8cases by CR and in 10 cases by CT.

结果：感染组12例中(包括化脓性感染4例，胸壁结核8例)，CR准确诊断4例，CT诊断11例；软组织肿瘤组16例中(包括脂肪瘤7例，纤维肉瘤4例，血管瘤、神经纤维瘤、恶性纤维组织细胞瘤、侵袭性纤维瘤病和脂肪肉瘤各l例)，CR准确诊断3例，CT诊断14例；骨肿瘤和肿瘤样病变组11例中(包括骨纤维异常增殖症7例，软骨瘤2例，多发性骨髓瘤和骨嗜酸性肉芽肿各1例)，CR准确诊断8例，CT诊断10例。

Among them, in tumour of glue mother cell, visible head pledges fasciculus is interrupted in vain, its stop fiber to be able to be through corpus callosum; in meningeal tumour, visible tumour oppresses the head that cause pledges the fiber shift and remaining, fasciculus; that is departed is in in vain a tumour of cell of metamorphic star form is medium, DTT expression sends place head to pledge fasciculus is interrupted in vain formerly for tumor and tumor countershaft dash forward infiltration.

其中，在胶母细胞瘤中，可见脑白质纤维束中断，其终止纤维可通过胼胝体；在脑膜瘤中，可见肿瘤压迫引起的脑白质纤维移位以及残存、被分离的纤维束；在间变性星形细胞瘤中，DTT表现为肿瘤原发部位脑白质纤维束中断以及肿瘤对轴突的浸润。

These observations may provide a vaccine strategy for cancer therapy through the induction of the autoimmunity against the molecules associated with tumor growth in a cross-reaction with a single xenogeneic homologous gene and may be of importance in the further exploration of the applications of other xenogeneic homologous genes identified in human and other animal genome sequence projects in cancer therapy.

这些结果提示，通过单个异种同源基因以交叉免疫的方式打破肿瘤生长相关分子的自体免疫耐受是一种新的肿瘤疫苗治疗途径，并显示出进一步探索人类和其他种属的异种同源基因在肿瘤免疫治疗应用中的重要性。

In 5 cases of cryptorchidism with malignant change 2 inguinal,2 ab- dominal,1 bilateral scrotal were reported.

5例隐睾恶性瘤中，腹股沟隐睾肿瘤2例，腹内隐睾肿瘤2例，双侧阴囊内肿瘤1例。

In contrast, cancer cells lacking functional P53 would be expected to be sensitive to viral replication and subsequent cytolysis. However P53 defections wildly exist in most of human cancer cell, deletion of E1B-55kD gene can make the adenovirus target at p53 mutation tumor cell.

以往的研究表明，大部分人类肿瘤中均存在p53基因突变，因此E1B55kD蛋白缺失的重组病毒只能在P53功能异常的肿瘤细胞中复制，而在正常细胞中该重组病毒由于缺乏对抗P53蛋白的病毒产物，不能有效复制，因此具有肿瘤靶向治疗的特点。

The general rule I learned from my cytopathology fellowship is that if a thyroid neoplasm looks not perfect for papillary carcinoma, follicular neoplasm, or Hurthle cell neoplasm, think about medullary carcinoma.

我从细胞同行那学习的经验是这样的，如果一个甲状腺肿瘤不完全象乳头癌，不完全象滤泡性肿瘤，也不完全象嗜酸细胞性肿瘤，这个时候，可能就是髓样癌。

To study the applicable prospect of suicide gene on tumor therapy in clinic,we cloned the gene of D-amino acid oxidase and the gene of yeast cytosine deaminase.We hope to establish the transgenic mices of DAAO gene and YCD gene,and the two transgenic strain mices are valuable animal system for studying the biological characteristic of DAAO gene and YCD gene ,for studing the killing activity of DAAO/D-Ala and YCD/5-FC gene therapy systems on tumor.The D-amino acid oxidase gene derived from R.gracilis and it could oxidize D-amino acids. Hydrogen peroxide(H2O2) is a reactive oxygen species generated in the deamination of D-Ala catalyzed by DAAO.

为了探讨自杀基因在临床肿瘤治疗中的应用前景，建立自杀基因肿瘤治疗评价的动物模型，我们克隆了D-氨基酸氧化酶(D-amino acid oxidase，DAAO)基因和酵母菌胞嘧啶脱氨酶(yeast cytosine deaminase，YCD)基因，希望建立DAAO基因及YCD基因转基因小鼠，为研究DAAO及YCD基因的生物学特性、开发和评价DAAO／D-Ala及YCD／5-FC自杀基因系统进行肿瘤治疗建立良好的实验动物模型。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。