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The results showed that the contents of glutamic-pyruvic transaminase and glutamic oxaloacetic transaminase in part of the dogs were high and spontaneous pathologic changes occurred in the important organs, such as lung, kidney and brain. The incidences of interstitial pneumonia, cerebral ependymitis and vascular infiltration were high. Cloudy swelling and vasular degeneration appeared in part of hepatocytes and epithelial cells of renal tubules.

实验结果为部分犬的肝功能谷丙转氨酶和谷草转氨酶偏高;肝、肺、肾和大脑等重要脏器有自发性病理改变;肺的间质性肺炎和大脑室管膜炎及血管围管性浸润发生率较高,部分肝细胞和肾小管上皮细胞呈现浊肿或空泡变等。

Cases healthy subjects served as control. In addition, density of glomerular matrix membrane and quantity of cell in glomeruli were measured with CMIAS image analysis system by computer. Global sclerosis, cellular crescents, fiber or fibrocellular crescents were measured with Memphis scope. Tubulointerstitial lesions were examined with semi-quantitative grades (including O-III grades).Results Compared to normal control, there was a significant increase of urinary TGF-betaK IL-6 and Col-lV levels in patients with IgAN (p. 01). There were also significantly positive correlation between the levels of urinary TGF-betaK Col-IV and density of glomerular matrix membrane ., interstitial fibrosisp.

采用酶联免疫吸附法测定尿TGF-β1(Transforming growth factor-β1)、尿IL-6(interleukin-6)和尿Col-Ⅳ(type Ⅳ Collagen);采用免疫组织化学法检测肾组织TGF-β1、Col-Ⅳ表达;应用CMIAS多功能真彩色病理图像分析系统对肾小球基质基底膜面密度和细胞个数进行半定量测定;对球性硬化、节段硬化、细胞新月体及纤维或纤维细胞新月体所占肾小球百分数和肾小球IgA沉积免疫荧光强弱的判断采用Memphis法进行评分;肾小管间质病变程度采用光镜下半定量分级法(包括0-Ⅲ级)。

To measure the renal interlobar arterial bloodflow parameters via Doppler ultrasonography may act as an approach to the evaluation of renal function and the awareness of disease condition.

通过彩色超声多普勒法测定肾叶间动脉血流参数可以用来评价肾功能和把握肾脏疾病的状态。

Methods:The blood flow spectrum of main renal arteries,segmental arteries,interlobar arteries and arcuate arteries were measured in 51 cases of serologically proved EHF and 40 normal subjects using color Doppler ultrasonography.

用彩色多普勒超声诊断仪检测了 40例正常人和 5 1例经血清学证实的 EHF患者,测定了病程中各期肾门部肾主动脉、段动脉、叶间动脉、弓形动脉的血流频谱参数。

Objective: To observe the expression of bone morphogenic protein-7 (BMP-7) in the kidney of rats with unilateral ureteral obstruction, and to explore the relationship between BMP-7 and renal tubulointerstitial lesion.

目的:观察单侧输尿管梗阻大鼠模型中骨形态发生蛋白7(BMP-7)在肾组织中的表达部位,动态变化及其与肾小管间质损害的关系。

It was reported that OP-1 was responsible for the induction of nephrogenic mesenchyme during the development of embryonic kidney. Absence of OP1 would lead to kidney dysplasia. With OP-1 gene knock-out, nude mice died of renal failure within the first 24 hours after birth.

研究发现,OP-1在胚胎肾脏发育期间与肾原性间充质的诱导有关,其缺乏导致肾脏发育不良,OP-1基因敲除突变型的裸鼠在出生后24小时内死于肾功能衰竭。

Methods Twenty four patients with chronic renal diseases and 48 healthy volunteers were examined with SS-EPI DWI at 3.0T MR. In chronic renal disease group, RIF of 14 patients who received renal biopsy was determined as grade Ⅰ and Ⅱ based on the tubule- interstitial damage degree, while RIF of 10 patients with uremia, who did not receive biopsy but had nephrogenic renal atrophy, was categorized as grade Ⅲ.

对照组(48例正常志愿者)和慢性肾病组(24例慢性肾脏疾病患者)在肾脏常规MR扫描后行DWI扫描,慢性肾病组14例行穿刺活检,根据病理结果将肾小管间质损害程度分为Ⅰ、Ⅱ级;另10例肾脏体积缩小的慢性肾功能衰竭尿毒症期患者定为Ⅲ级。

Simvastatin may suppress interstitial fibrosis by effect CTGF、suppress cell proliferation、redue extracellular matrix accumulation.

辛伐他汀可以抑制CTGF、抑制肾小管上皮细胞的转分化、减轻细胞外基质的积聚,从而减轻间质纤维化,发挥肾保护作用。

ResuIt:1. JDD can significantly improve the digestive system symptoms and physical strength of CRF patients. It can also reduce the urine protein.plasma lipids,BUN and Scr notably.The total effective rate of treatment group is 86.67%,better than that of control group(P.05).2.The experiment revealed JDD can restrain the crescendo-developed mechanism of CRF,which is achieved by decreasing blood ET-1,plasma lipids,urine protein etc.lt also can lighten glomerular sclerosis,inhabit uriniferous tubule-interstitial fibrosis.

结果:1。降氮汤能明显改善消化道症状及体力等一般情况,显著降低尿蛋白,血脂和血Scr、BUN,其总有效率86.67%,显著优于尿毒清对照组(P<0.05)。2,实验发现降氮汤可通过降低血ET-1、血脂、尿蛋白等途径抑制CRF的渐进性发展机制,减轻肾小球硬化和肾小管-间质纤维化,具有肾保护作用。

Perfusion characteristics, including blood flow, blood volume, and permeability of renal mass parenchyma and renal cortex in affected and normal kidneys were calculated from Siemens Body PCT (VB20B) software, and the perfusion characteristics among renal mass parenchyma and renal cortex in affected and normal kidneys were compared.

比较不同病理类型肾脏占位病变实质间灌注特征的差异,以及占位病变实质、患侧正常肾皮质及健侧肾皮质灌注特征的差异。

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