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Results: 32 patients with PNS suffered from acute oliguria or anuria,acute deterioration of renal function and rising of serum BUN and SCr, excluding secondly glomerular disease and acute tubular necrosis?

结果 :原发性肾病综合征在病情中突然发生少尿或无尿,肾功能急骤恶化,血尿素氮及肌酐上升,排除继发性肾小球疾病及其他原因引起的急性肾小管坏死、急性间质性肾炎和双肾静脉主干血栓形成,经甲基强的松龙和环磷酰胺或吗替麦考酚酯及标准疗程泼尼松、血液透析等对症治疗,32例患者肾功能均改善。

They were diagnosed as chronic tubulointerstitial nephropathy accompanied with renal tubular acidosis, renal glucosuria, hyposthenuria and different degree of chronic renal dysfunction.

结果:9例均为中老年患者,临床上均表现为慢性小管间质性肾病,均有肾小管酸中毒、肾性糖尿、低渗尿和不同程度的慢性肾功能减退。

In addition, glomerular enlargement, hypertrophy, and glomerular mesangial deposits lead to a progressive glomerulosclerosis and eventual nephron loss.

因此,肾丝球体的扩大,肥大,和肾丝球间质沈积,导致累进式肾丝球体硬化,以及最后一个肾脏小过滤器丧失。

Mmol/L and 385±24. 6 mmol/L. At 3, 7 and 14 days after transplantation, the grafts were removed for a morphological observation under histological studies. In 7d, the macro pathology in control group's renal allograft was packed by gastrocolic omentum thickly, open the package and dissect the kidney, the color was paleness and interstitial edema.

对移植后第3、7、14d移植肾的形态学观察:对照组在移植后7d打开大鼠腹腔,可见移植肾被受体的大网膜包裹,网膜明显增厚,剖开移植肾脏,外观色泽苍白间质水肿明显,呈&大白肾&样改变,对照组动物一般在移植后12d左右死亡,死亡时移植肾组织包裹更加严重,肾脏部分发生液化。

BACKGROUND: Bone marrow mesenchymal stem cells can differentiate into renal parenchymal cells including renal intercapillary cells. BMSCs can repair kidney structure and function after damage.

摘要背景:研究发现骨髓间充质干细胞可向包括肾脏系膜细胞在内的肾实质细胞分化,且肾损伤后骨髓间充质干细胞具有修复肾脏结构和功能的作用。

Methods RI and PI of interlobar artery in 100 noncomplicated renal transplantation recipients were obtained by color Doppler ultrasonography at one month after transplantation.

在100例无并发症肾移植患者中,应用彩色多普勒超声,于肾移植术后1月测量移植肾叶间动脉的RI和PI。

Methods RI and PI of main renal artery and interlobar artery were obtained by color Doppler ultrasonography within the first week of transplantation.Then they were correlated with allograft glumerular filtration rate at 1 year.

在100例无并发症肾移植患者中,应用彩色多普勒超声,于肾移植术后1周内,测量移植肾肾动脉和叶间动脉的阻力指数和搏动指数,并与术后1年的移植肾肾小球滤过率进行相关分析。

FGFR4 expression was faint in renal vesicle and primitive tubules of S-shaped body, irrecognizable in urteric bud and podocyte of C-stage, negative in mesenchyme and condensing mesenchyme.

胚胎肾发生带内FGFR4表达微弱,肾囊泡和S型小体的上支和中间支,即原始肾小管上皮细胞部位有微弱表达,间充质、压缩间充质未见表达,输尿管芽及其末端壶腹和C-期足细胞表达不明显。

The second, many coccus in kidney, heart and pancreas were found besides liver cell degeneration, congestion of liver, epithelium cell degeneration, necrosis of tubuli tenales, kidney hemorrhage, cardiac muscle cell degeneration, heart hemorrhage.

病例2,肝细胞变性,肺淤血,肾小管上皮细胞变性、坏死,间质出血,心肌纤维变性,间质出血,肾、心、胰脏均可见到散在分布的球菌。

This may be explained by follows: First, Decoction Shenkangling can regulate the homeostasis of NEI network and reduce the increased activity of NF-κB to restrain the action of inflammatory-sclerotic media; Second, it can redress the disequilibrium of the ratio of TXA2/PGI2 to reform the hypercoagulable state; Third, it can enhance albumin and reduce cholesterol and triglyceride; Fourth, it can amend the renal damage and protect the function of renal tubule and stroma to prevent the transformation from MCD to FSGS; Last, it can lessen urine protein in AN rats markedly and relieve the side effects of prednisone.4. NF-κB, TXA2 and PGI2, along with the renal pathomorphology and so on can all be the indexes of the diagnosis of Symptom of "Kidney Deficiency and Blood Stasis" and the application of Methods of "Benefiting the kidney and Promoting blood circulation" in TCM.5. The curative effects on AN rats by treatment of integrating Traditional Chinese Medicine with prednisone are much better than using prednisone only. And the curative effects on AN rats by treatment of matching Decoction Shenkangling, having the function of "Benefiting the kidney and Promoting blood circulation", with Prednisone are much better than using Prednisone only.6. When it referred to decreasing urine protein, cholesterol and triglyceride and increasing albumin, Decoction Zhibodihuang excesses Decoction Taohongsiwu. However, when it referred to regulating the disequilibrium of TXA2/PGI2 and meliorating renal lesion, Decoction Taohongsiwu exceeds Decoction Zhibodihuang.7. The curative effects on AN rats by treatment of matching Methods of "Benefiting the kidney and Promoting blood circulation" with Prednisone overmatches using Prednisone matching Method of "Benefiting the kidney" or Method of " Promoting blood circulation" only.

益肾活血中药肾康灵能显著改善AN鼠的肾虚血瘀证的临床表现和实验指标,这可能与中药肾康灵能调理AN鼠机体的NEI网络功能稳态,降低异常升高的NF-κB活性,抑制免疫炎症/硬化介质环节,纠正失衡的TXA2/PGI2,改善AN鼠血液高凝状态,提高AN鼠的血清Alb,降低Ch和TG,减轻AN鼠的肾脏组织病理学变化,保护肾小管-间质功能,阻止MCD向FSGS转化;显著减轻AN鼠的尿蛋白水平以及减轻激素副作用有关。4、NF-κB、 TXB2和6-keto-PGF1α以及肾脏病理形态学改变等,都可作为中医肾虚血瘀证诊断和益肾活血法应用的客观指标。5、中西医结合干预AN鼠疗效优于单纯激素治疗;强的松配合益肾活血中药肾康灵组的综合疗效显著优于单纯强的松组。6、知柏地黄汤组在降低尿蛋白、提高血清Alb、降低Ch和TG疗效上优于桃红四物汤组;桃红四物汤组在纠正失衡的TXA2/PGI2和减轻肾脏病理损害方面优于知柏地黄汤组。7、激素配合益肾活血法干预AN鼠在一定程度上优于激素配合益肾法或活血法。

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