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Mesangial cells might derive from mesenchymal cells in the metanephrogenic blastema. The expression of α-SMA in developing mesangial cells is a transient phenomenon associated with the maturation of mesangial cells.

系膜细胞可能来源于生后肾组织的间充质细胞,α-SMA的表达短暂与肾小体系膜细胞的发育成熟密切相关。

Kidney pathology showed: the renal glomerulus in model group was damaged seriously, about 25% renal glomerulus was healthy. And the pathological changes involved renal glomerulus、tubulus renalis and interrenal nature. Those were broad response of inflammation.

8肾脏病理镜下见:实验组SD大鼠肾小球严重破坏,健全肾小球在25%左右,肾脏病理改变涉及肾小球、肾小管及肾间质,是广泛的炎性反应连续性破坏病变。

Methods Primary metanephric mesenchyme stem cells were cultivated and multi-directional differentiation was induced.

方法原代分离培养后肾间充质干细胞,在体外特定诱导条件下观察细胞向成骨细胞、脂肪细胞及肾小管上皮细胞的分化及其形态演变,采用细胞免疫荧光检测细胞表面特定蛋白的表达变化。

Objective To investigate the effects of piperazine ferulate on TGF-β1-induced renal interstitial fibroblast activation, and to explore the mechanism of PF in the prevention of renal tubulointerstitial fibrosis.

目的 观察阿魏酸哌嗪对转化生长因子-β1(TGF-β1)诱导肾成纤维细胞表型活化的影响,探讨其抗肾间质纤维化的可能机制。

At high magnification, many neutrophils are seen in the tubules and interstitium in a case of acute pyelonephritis .

高倍镜下,急性肾盂肾炎的病例中在肾小管和肾间质区可以看到有大量的中性粒细胞浸润。

After 2 years' follow up, the above measurements were performed again. The correlation of changes of GFR and changes of interlobar artery RI and PI was analyzed.

随访2年后再行一次上述超声和肾功能检查,比较叶间动脉RI、PI和肾功能的变化情况,作RI、PI变化值与GFR变化值的相关性分析。

The changes of RI and PI of interlobar artery measured by Doppler ultrasonography can be used to predict the changes of GFR in noncomplicated renal transplantation.

多普勒彩超动态监测移植肾叶间动脉的RI和PI变化能够预测移植肾肾功能的变化。

Results: The expression of CTGF protein and CTGF mRNA in the nomal and sham operation group is low in the intracytoplasm of Mesangial cells, renaltubular epithelial cells and renal interstitial cells. Compare with sham operation group, the expression of CTGF protein and CTGF mRNA as yellow particulate in the mode group was markedly increased, and the fibrosis of nephridial tissue is obvious. Panaxnotoginseng could significantly decrease the expression of CTGF protein and CTGF mRNA(P.05), and there was no significant difference between Panaxnotoginseng treatment group and Benazepril treatment group.

结果:正常组及假手术组肾小球系膜细胞、肾小管上皮细胞以及肾间质细胞胞浆内有少量CTGF蛋白及其mRNA的黄色颗粒状阳性反应物,模型组上述部位的CTGF蛋白及其mRNA呈强阳性表达,三七总皂苷组上述指标表达较模型组显著减少,有统计学差异(P.05),与阳性药物组比较差异不显著。

Results: Tubulointerstitial damage index, tubulointerstitial fibro- sis index, and expression of TGF-β1 in group U were significantly higher than those in group S (P.01). These indexes were obviously lower in group A than those in group U (P.05). TDI and TFI positively correlated with expression of TGF-β1 respectively.

结果:U组肾小管间质损伤指数及肾间质纤维化指数均明显高于S组(P.01);U组TGF-β1的表达均明显高于S组(P.01);A组的上述各指标分别较U组降低(P.05);TDI、TFI分别与TGF-β1的表达呈正相关。

At high magnification, many neutrophils are seen in the tubules and interstitium in a case of acute pyelonephritis.

高倍镜下,见急性肾盂肾炎的肾小管和肾间质中有中性粒细胞。

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