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肾腺瘤

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In contrast, AMACR expression was detected in 14 of 18 nephrogenic adenomas (78%) and in 96 of 100 prostatic adenocarcinomas (96%).

相反,18例肾源性腺瘤中的14例(78%)和100例前列腺腺癌中的96例(96%)表达AMACR。

We conclude that (1) S100A1 is a specific and sensitive immunohistochemical marker to differentiate nephrogenic adenoma from prostatic adenocarcinoma;(2) AMACR immunostaining does not seem to be a useful marker in distinguishing between these 2 lesions;(3) given that both S100A1 and AMACR have been reported to be expressed in renal tubular cells and in a subset of renal cell neoplasms, our findings confirm the histogenetic relationship between nephrogenic adenoma and renal tubular epithelium.

我们总结认为:(1)鉴别肾源性腺瘤和前列腺腺癌,S100A1既特异又敏感;(2)AMACR免疫染色鉴别这两种病变,效用不佳;(3)文献报道S100A1和AMACR均表达于肾小管上皮和部分肾细胞肿瘤,在此前提下,我们的结果证实了肾源性腺瘤和肾小管上皮之间的组织发生关系。

In this study, we investigated the expression of S100A1 and AMACR in 18 nephrogenic adenomas and in 100 prostatic adenocarcinomas. A strong and distinct cytoplasmic or nucleocytoplasmic staining of S100A1 was found in 17 out of 18 cases of nephrogenic adenoma (94%), but never in prostatic adenocarcinoma.

本研究中,我们研究了S100A1和AMACR在18例肾源性腺瘤和100例前列腺腺癌的表达情况。18例肾源性腺瘤中的17例(94%),瘤细胞胞浆或胞浆加胞核强烈、独特表达S100A1,而前列腺腺癌无一例表达。

The compositions are useful in contraception and hormone replacement therapy and in the treatment and/or prevention of uterine myometrial fibroids, benign prostatic hypertrophy, benign and malignant neoplastic disease, dysfunctional bleeding, uterine leiomyomata, endometriosis, polycystic ovary syndrome, and carcinomas and adenocarcinomas of the pituitary, endometrium, kidney, ovary, breast, colon, and prostate and other hormone-dependent tumors, and in the preparation of medicaments useful therefor.

所述组合物也可用于避孕和激素替代治疗和治疗和/或预防子宫的子宫肌层纤维瘤、良性前列腺肥大、良性和恶性肿瘤性疾病、功能异常性出血、子宫肌瘤、子宫内膜异位、多囊卵巢综合征和垂体、子宫内膜、肾、卵巢、乳房、结肠和前列腺的癌和腺癌及其它激素依赖性肿瘤,以及用于制备对其有用的药物。

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