肾素

The pathogenesis of diabetic nephropathy is multifactorial, and the renin angiotensin aldosterone system plays an important role.

糖尿病肾病的发病是多因素的，其中肾素-血管紧张素-醛固酮系统在其中扮演重要角色。

Objective To observe the effects of Losarten on plasma renin, Angiotensin Ⅱ and Aldosterone in hypertensive patients.

目的 观察氯沙坦治疗轻中度高血压病的临床疗效及对血浆肾素、血管紧张素-醛固酮的影响。

Therefore, it suggests that angiotensin system may play an important role in the form of PAH.

提示肾素-血管紧张素系统可能在PAH形成中起较为重要的作用。

Methods 48 patients were given valsartan 80 mg/d for 12 weeks, the heart function parameter, the amount of rennin, angiotonin and aldosterone were tested before and after therapy.

48例chf患者均口服缬沙坦，80 mg/d，疗程12周，比较治疗前后心功能指标变化，并检测治疗前后肾素、血管紧张素及醛固酮的含量。

Foundation research also suggested that low protein diet keto-acids produced renal protective effects not only through the hemodynamic effect of extenuation of high infusion and high pressure in glomeruli, but also through the non-hemodynamic effects, such as reducing the expression of renin and TGF-β, ameliorating of oxidative stress and lessening the excretion of cellular matrix of mesangial cell.

基础研究也证实低蛋白饮食或合并酮酸治疗既能通过改善高灌注高滤过的异常血流动力学来延缓肾功能恶化的进展，还能通过降低肾素表达、改善氧化应激、减少转化生长因子(TGF-β1)表达和减轻系膜细胞分泌细胞外基质等非血流动力学效应发挥肾脏保护作用。

International Circulation: What about direct renin inhibition and its effect on cardio-renal protection?

国际循环》：直接的肾素抑制剂是如何发挥心肾保护作用的？

Could you please discuss the mechanism of direct renin inhibition in antihypertension and cardio- renal protection?

请您谈谈直接肾素抑制剂在降压和心肾保护方面的作用机理。

The present study investigated the interaction between sodium loading and enalapril on renin synthesis and secretion in hydronephrotic mice.

本文应用肾积水小鼠，探讨了钠负荷及依那普利对肾素合成及分泌的相互作用。

Additional｜y, although the polymorphism of angiotensin-converting enzyme liD is related with and cardi disease, the research results in different races, nations even the same race and nation are not exactly the same.

血管紧张素转换酶是肾素一血管紧张素系统的关键酶，其基因I/D多态性在不同种族、不同民族等正常人群中分布存在差异，与某些心脑血管疾病的易感性，严重性及预后相关。

objective to observe the protective effect of qiliqiangxin capsule in rabbit heart ventricle reconstitution of chronic heart failure.methods using the method of giving rabbit abdomen aorta half ligations to build the chronic heart failure model to observe qiliqiangxin capsule the effect to blood flow mechanics index,room wall thickness,heart exponent and heart ventricle reconstitution biochemistry index.results qiliqiangxin capsule could reduce effectively bp,lvsp,lvedp,t wave,improve room wall thickness and heart exponent,reduce angii and alt,all the paramenters ahd notable difference,composed to those of model group (p＜0.05,p＜0.01).conclusion qiliqiangxin capsule can improve the blood flow mechanics change of chronic heart failure rabbit,which has notable inhibitory action on heart ventricle reconstitution which originate from chronic heart failure.inhibition of ang ii,alt of immune nerve endocrine system may be a mechanism of qiliqiangxin capsule.

观察血流动力学、标志心室重构的室壁厚度及心脏指数及肾素―血管紧张素―醛固酮系统相关生化指标的变化。结果芪苈强心胶囊可有效降低血压、左室压、左室末期舒张压、t波，改善室壁厚度和心脏指数，降低血清血管紧张素ii及醛固酮水平，与模型组比较均有显著性差异(p＜0.05，p＜0.01)。结论芪苈强心胶囊可改善慢性心力衰竭兔血流动力学的变化，对慢性心力衰竭引起的心室重构具有显著抑制作用，其机制可能与该药发挥抑制神经内分泌免疫系统rass中angii、ald的水平有关。

The labia have now been sutured together almost completely.The drains and the Foley catheter come out at the top.

此刻阴唇已经几乎完全的缝在一起了，排除多余淤血体液的管子和Foley导管从顶端冒出来。

To get the business done, I suggest we split the difference in price.

为了做成这笔生意，我建议我们在价格上大家各让一半。