肾病变的

Yi Shen Granule could protect renal functions, depress BUN and Cre, ameliorate a series of clinical symptoms which were caused by decompensate, restrain hypertrophy of the remains kidney, decrease the incidence of glomerular, delay the development of CRF, strengthen anti-stressor and immune ability.

益肾颗粒具有保护肾脏功能的药理作用，它可以减缓慢性肾功能衰竭引起的肾脏实质性病变恶化过程，降低血中BUN和Cre的含量，改善慢性肾功能衰竭引起的氮质血症、代谢紊乱和各系统受累表现的一系列临床症状。

Kidney pathology showed: the renal glomerulus in model group was damaged seriously, about 25% renal glomerulus was healthy. And the pathological changes involved renal glomerulus、tubulus renalis and interrenal nature. Those were broad response of inflammation.

8肾脏病理镜下见：实验组SD大鼠肾小球严重破坏，健全肾小球在25%左右，肾脏病理改变涉及肾小球、肾小管及肾间质，是广泛的炎性反应连续性破坏病变。

To master basic and complex pathological change of atherosclerosis; the characteristic of coronary AS, brain AS and nephridium

掌握动脉粥样硬化症的基本病变和复合病变，冠状动脉、脑动脉及肾动脉粥样硬化病变特点；冠状动脉性心脏病的类型、病变及后果

After being treated with Nephritis NO.1 Prescription, NO and the ET-1 contents in Model group recovered(P〈0.05)2、Nephridial tissue examination indicated that there were lessened microscopic structural pathological changes ,cellular proliferation and widening mesangial region in mesangial cells through treatment compared to Model Control , Conclusions :1 For Mesangial Proliferative Nephritis , Manshen NO.1Prescription has satisfactory therapeutic effects, It can improve symptoms, restrain accrementition in intercapillary cells and mesangial region, thus prevent nephric tubule's indurascent and prevent renal failure.2、Manshen NO.1 Prescription can increase NO contents; reduce ET-1 contents in Model control.

结果：1、与正常对照组相比，模型组血清NO含量减低(P〈0.05)，而ET-1的含量升高P〈0.05〉，给予慢肾1号方治疗后，可明显提高系膜增生性肾炎模型组血清NO(P〈0.05〉，减低血清ET-1的含量P〈0.05〉，2、肾组织学检查显示：经慢肾1号方治疗后，与模型组相比，肾小球系膜细胞增生及系膜区增宽等超微结构病变均有所减轻。

Cases healthy subjects served as control. In addition, density of glomerular matrix membrane and quantity of cell in glomeruli were measured with CMIAS image analysis system by computer. Global sclerosis, cellular crescents, fiber or fibrocellular crescents were measured with Memphis scope. Tubulointerstitial lesions were examined with semi-quantitative grades (including O-III grades).Results Compared to normal control, there was a significant increase of urinary TGF-betaK IL-6 and Col-lV levels in patients with IgAN (p. 01). There were also significantly positive correlation between the levels of urinary TGF-betaK Col-IV and density of glomerular matrix membrane ., interstitial fibrosisp.

采用酶联免疫吸附法测定尿TGF-β1(Transforming growth factor-β1)、尿IL-6(interleukin-6)和尿Col-Ⅳ(type Ⅳ Collagen)；采用免疫组织化学法检测肾组织TGF-β1、Col-Ⅳ表达；应用CMIAS多功能真彩色病理图像分析系统对肾小球基质基底膜面密度和细胞个数进行半定量测定；对球性硬化、节段硬化、细胞新月体及纤维或纤维细胞新月体所占肾小球百分数和肾小球IgA沉积免疫荧光强弱的判断采用Memphis法进行评分；肾小管间质病变程度采用光镜下半定量分级法(包括0-Ⅲ级)。

Results CsA clearly decreased creatinine clearance and increased urinary excretion of N-acetyl-β-D-glucosaminidase in rats as compared with those in the vehicle group. Morphologic changes consisted of vacuolization of tubular cell, expansion of the interstitium and interstitial fibrosis, hyalinization of afferent arterioles. Severity of the injury was related to the dosage of CsA. Striped interstitial fibrosis and arteriolopathy were more severe in the rats treated with CsA and low-salt diet than with CsA and normal diet.

结果 用CsA的大鼠出现尿量增多、内生肌酐清除率下降、尿N-乙酰-β-D-氨基葡萄糖苷酶排泄增多等；病理上表现为不同程度的细胞浊肿、空泡变性及灶性分布的间质纤维化和小动脉病变，随CsA剂量的增加，病变呈加重趋势；结合低钠饮食，CsA慢性肾毒性病变明显加重。

Ons:Therapy integrated traditional Chineses and western medicine can decrease the damage of nephric tubule's interstitial substance in NS

征可以减轻肾综时肾小管损伤，减少肾小管病变所带来的不良预后，提高疗效，有较高的临床应用价值。

All rats were killed twelve weeks later, the right kidneies were used for observing pathological change, and the expression of MCP-1 in nephridial tissue were detected by immunohistochemical method. Results (1) Change of morphology: the structure of renal tubule was normal in control group, most glomcruluses were segmented sclerosis in GS group, the renal lesions in valsartan group was minorer than this in GS group.

结果 (1)形态学改变：对照组大鼠肾小管结构正常；肾小球硬化组多数肾小球呈节段性硬化，许多肾小球及肾小管受累；缬沙坦治疗组肾脏病变轻于肾小球硬化组，且肾小球硬化指数明显低于肾小球硬化组(P.01)；(2)MCP-1的表达：对照组肾小管中有少量MCP-1的表达，在肾小球内几乎不表达，在肾小球硬化组和缬沙坦治疗组肾小球及肾小管内表达皆强于正常对照组(P.01)。

The location, the spectrum, the shape of tumer and the degree of uretal hydrocele, the change of surrounding tissue are right demonstrated in MSCT. The enhancement scan can supply indirectly information to understand function of the kidneys. MSCT can supply very valuable information for clinic in treatment planning and prognosis evaluation, especially, CPR and MPR imaging have great value in exhibiting the whole of lesions.

MSCT可准确显示输尿管移行细胞癌的发生部位、病变范围、形态、病侧输尿管积水扩张和周围侵犯情况，增强扫描间接评价患侧肾脏及对侧肾脏肾功能情况，为外科手术方案选择提供指导依据；MPR和CPR图像在显示病变全貌上具有显著优势。

The two can cause ultrastructural pathogenesis widely in many organs and tissues such as hepar, pancreas, lien, ren, pulmo, cerebral, cerebellum, cor, muscular and so on, of them ,caused by i~olates YG97 and Y98 more obvious in epithelial cells of digestive tract and unobvious in epithelial cells of respiratory tract ,but ultrastructural pathogenesis caused by NDV strain F48E8 ,more obvious and more serious in glandularis and muscularis ventriaculi and in epithelial cells of respiratory tract .

将鹅源分离株YG_(97)、鸡源分离株Y_(98)和NDV强毒株F_(48)E_8感染SPF鸡，运用扫描电镜和透射电镜观察该二株病毒对机体细胞的影响，结果显示三株禽副粘病毒均引起机体肝、胰、脾、肾、肺、小脑、大脑、心和肌肉等实质器官组织细胞的超微病变，其中YG_(97)和Y_(98)引起消化道粘膜上皮细胞发生微绒毛脱落、纤毛脱落、分泌颗粒增多、细胞游离面破溃等显著的超微病变，引起气管粘膜上皮细胞的不显著超微病变；F_(48)E_8强毒株引起胃粘膜显著而严重的超微病变；还引起气管粘膜上皮严重的超微病变。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。