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肾溶解

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I love the amniotic fluid when it spills out of the bag. I love the kidney with its painful gallstones, its gravel and whatnot; I love the urine that pours out scalding and the clap that runs endlessly; I love the words of hysterics and the sentences that flow on like dysentery and mirror all the sick images of the soul; I love the great rivers like the Amazon and the Orinoco, where crazy men like Moravagine float on through dream and legend in an open boat and drown in the blind mouths of the river. I love everything that flows, even the menstrual flow that carries away the seed unfecund. I love scripts that flow, be they hieratic, esoteric, perverse, polymorph, or unilateral. I love everything that flows, everything that has time in it and becoming, that brings us back to the beginning where there is never end: the violence of the prophets, the obscenity that is ecstasy, the wisdom of the fanatic, the priest with his rubber litany, the foul words of the whore, the spittle that floats away in the gutter, the milk of the breast and the bitter honey that pours from the womb, all that is fluid, melting, dissolute and dissolvent, all the pus and dirt that in flowing is purified, that loses its sense of origin, that makes the great circuit toward death and dissolution.

我爱从羊膜中溅出的羊水;我爱生着引起痛苦的的结石、肾砂和诸如此类东西的肾脏;我爱撒出的热呼呼的尿和久治不愈的淋病;我爱歇斯底里的疯话、像拉痢疾一样一泻而出的句子和灵魂全部病态的映像;我爱亚马逊河和奥里诺科河这样的大河,那儿摩拉瓦基乃之流的狂人在一只无顶的小船上漂过了梦和古老的传说,淹死在瞎眼的河口中;我爱流动的一切,甚至爱女人来月经时流出的血,它冲走了生育能力不强的精子;我爱会流动的手稿,不论它们是用象形文字写的、深奥的、反常的、多形体的或是单边音的;我爱流动的一切,一切其中有时间的和适当的东西,它们把我们带回永远不会结束的开始中,即先知们激烈、令人狂喜的猥亵,宗教狂的智慧,牧师和他的橡皮连祷文,妓女的下流话,从排水道里漂走的唾液,乳房里的奶汁和子宫里流出的带苦味的蜜水,以及一切流质的、溶化的、放荡的和有溶解力的,所有在流动中得到静化的脓和脏物,那些失去其出身意识的东西和那些将大循环驱向死亡和瓦解的东西。

I love the amniotic fluid when it spills out of the bag. I love the kidney with its painful gallstones, its gravel and what not; I love the urine that pours out scalding and the clap that runs endlessly; I love the words of hysterics and the sentences that flow on like dysentery and mirror all the sick images of the soul; I love the great rivers like the Amazon and the Orinoco, where crazy men like Moravagine float on through dream and legend in an open boat and drown in the blind mouths of the river. I love everything that flows, even the menstrual flow that carries away the seed unfecund. I love scripts that flow, be they hieratic, esoteric, perverse, polymorph, or unilateral. I love everything that flows, everything that has time in it and becoming, that brings us back to the beginning where there is never end: the violence of the prophets, the obscenity that is ecstasy, the wisdom of the fanatic, the priest with his rubber litany, the foul words of the whore, the spittle that floats away in the gutter, the milk of the breast and the bitter honey that pours from the womb, all that is fluid, melting, dissolute and dissolvent, all the pus and dirt that in flowing is purified, that loses its sense of origin, that makes the great circuit toward death and dissolution.

我爱从羊膜中溅出的羊水;我爱生着引起痛苦的的结石、肾砂和诸如此类东西的肾脏;我爱撒出的热呼呼的尿和久治不愈的淋病;我爱歇斯底里的疯话、像拉痢疾一样一泻而出的句子和灵魂全部病态的映像;我爱亚马逊河和奥里诺科河这样的大河,那儿摩拉瓦基乃之流的狂人在一只无顶的小船上漂过了梦和古老的传说,淹死在瞎眼的河口中;我爱流动的一切,甚至爱女人来月经时流出的血,它冲走了生育能力不强的精子;我爱会流动的手稿,不论它们是用象形文字写的、深奥的、反常的、多形体的或是单边音的;我爱流动的一切,一切其中有时间的和适当的东西,它们把我们带回永远不会结束的开始中,即先知们激烈、令人狂喜的猥亵,宗教狂的智慧,牧师和他的橡皮连祷文,妓女的下流话,从排水道里漂走的唾液,***里的奶汁和子宫里流出的带苦味的蜜水,以及一切流质的、溶化的、放荡的和有溶解力的,所有在流动中得到静化的脓和脏物,那些失去其出身意识的东西和那些将大循环驱向死亡和瓦解的东西。

Under transmission electron microscope, cellular swelling in brain tissue, nuclear membrane of neuron has incisures, some chromatic agglutination, group A mainly appears endoplasmic reticulum distention and glial cell endocytosis, while group B mainly appears histolysis; cardiac fibrous structure is chaotic, Z line concentrates, mitochondria swelling, nucleus deform; the ecphyma of podocyte becomes thinner and longer like villus, some mix together, plasma membrane infolding of renal cells decreases, mitochondria malformation, cells in lumens.

透射电镜观察显示,试验组动物脑组织细胞肿胀,神经元核膜出现切迹,部分染色质凝集,A组动物出现内质网扩张及胶质细胞吞噬现象,B组动物以组织溶解为主;心肌纤维结构紊乱,Z线聚集,收缩带形成,线粒体肿胀,核变形;肾小球足突细长,绒毛化,并可见足突融合,肾小管上皮细胞质膜内褶减少,线粒体畸形,管腔可见脱落细胞,上述改变均以B组为著。

We also have observed some organs pathological changes of juvenile Jian Carp, such as pancreas acinous gland and zymogen granules of acinous gland cell disappearing, intercellular substance hyperplasia and inflammatory cells soakage, hepatatrophia, liver cell granular or vacuolar degeneration and necrosis, karyolysis or pyknosis, glycogen granules decreasing, metanephros atrophy, metanephric canaliculus epithelium granular or vacuolar degeneration and necrosis, mitochondrion swelling and mitochondrion cristae disappearing, karyolysis, distal convolutal tubule microvilli desquamating, spleen marrow cell degeneration and necrosis, intercellular substance of spleen hyperplasia, spleen atresia, blood corpuscle disappearing.

后肾土黄色、淡褐色或苍白色,肾小管上皮细胞肿胀、颗粒或水泡变性、坏死,细胞内有大量血细胞流出,线粒体肿胀,嵴结构消失,细胞核溶解,肾间质甲状腺滤泡和拟淋巴细胞增生,远曲小管微绒毛脱落、管道细胞界限不清。心脏肌纤维肿胀、颗粒或空泡变性,严重的肌纤维溶解、变细或断裂,肌纤维间水肿、炎性细胞浸润,部分心肌细胞核浓缩。脾脏暗褐色,脾髓质细胞变性、坏死,拟淋巴细胞明显减少,淋巴细胞岛少见、岛中细胞成份减少,黑素巨噬细胞中心减少、体积缩小,脾脏网状基质水肿,脾窦闭锁,血细胞减少。

Very rarely, this myopathy leads to muscle breakdown and fatal kidney failure.

非常罕见的,这种肌病会导致肌溶解和致死性肾衰。

Resent studies have highlighted the effect of propofol infusion syndrome. Nevertheless, studies of mechanisms of PRIS are still few. Propofol infusion syndrome is a rare and often fatal syndrome described in critically ill patients undergoing long-term propofol infusion at high doses.

异丙酚输注综合征(propofol infusion syndrome,PRIS)是指对危重患者长时间、大剂量静脉输注异丙酚后引起的严重代谢性酸中毒、心衰、横纹肌溶解和肾功能衰竭等严重并发症,甚至导致死亡。

The liver cell and renal tubular cell showed to dissolve putrescence.

肝细胞、肾小管细胞呈现溶解性坏死。

Results:①All gallstones type Ⅰ and Ⅳ in animal models were dissolved quickly, however, MTBE showed somewhat toxicity in inhibiting CNS, so that the dose of MTBE should be controlled precisely.②No abnormal change of liver and renal functions of dogs were found before and after operations.③Choloecyst pathological sections of gallbladder suggested that no evident of damage and inflammation of gallbladder was of found. Hemopexis with reversible histological change was observed in hepatic sinusoid and centeral vein short time after administation of MTBE.

结果:①动物模型的Ⅰ、Ⅳ型结石均全部迅速溶解,但MTBE有一定毒性,其对中枢神经系统有一定的抑制作用,应用时须严格掌握单位时间内的灌注剂量及总量(控制在60ml左右);②实验犬实验前后的肝、肾功能检查无异常;③病理检查结果提示MTBE对胆囊组织无明显损伤,无严重炎性反应,给药后短期内肝窦和中央静脉有凝血现象,但其组织学变化是可逆的。

Micrococcal lysis assay of the milk samples showed that the cDNA was efficiently expressed in the mammary glands with similar expression levels ranging from 60 to 87 mg/L. Different tissues of each vector-injected mouse were assayed for transcription of hLYZ mRNA by dot-blotting and for expression of hLYZ activity by Micrococcal lysis assay. The results showed that expression of the three recombinant vectors was mainly restricted to mammary glands with some degrees of ectopic expression in spleen, intestines and/or kidney.

注射后72 h采集乳样,经微球菌溶解实验证明,3组小鼠乳汁中hLYZ的表达量分别为87、69、60 mg/L;从每组小鼠的12种组织提取总RNA,经Dot blotting检测证明,三种重组载体除在乳腺中表达外,p205C3LYZ还在小鼠的脾和肠、pBJLYZ在脾、pBCLYZ在脾和肾中具有一定的异位表达;在有hLYZ mRNA转录的上述脏器中用微球菌溶解试验均可检测到hLYZ活性。

ABSTRACT] Objective To establish a stable, useful culture system for human osteoclasts and to investigate the effect of osteoblasts on the differentiation, proliferation and activation of osteoclasts so as to provide a base for the studies on prevention and treatment of osteolysis and osteoporosis.

摘要] 目的建立成人破骨细胞体外培养的方法,观察成骨细胞对破骨细胞分化、增殖和功能的影响,为进一步研究补肾中药防治骨溶解和骨质疏松症提供基础。

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