肾心的

CaN Aβ gene silencing can reduce myocardial hypertrophy in cultured cells, si1280 (21bp) of CaN Aβ gene is the most effective target site for siRNA. The method of intrapericardial injection of plasmid, microbubbles and erzymes can improve transfection efficiency of non-viral plasmid with satisfying targeted transfection. But the scope of transfected myocytes is still limited. CaN Aβ shRNA expressing plasmid transfection in vivo by pericardial injection results in decreased CaN Aβ protein expression of small part of myocytes, and CaN Aβ mRNA only shows decreased trend. The dosage of non-viral vector and the parameters of ultrasound energy should be optimized in further study.

结论RNAi技术抑制CaN Aβ基因表达可有效减轻Ald诱导的心肌细胞肥大程度；CaN Aβ基因中si1280(21bp)片段为实现RNAi的更有效片段；微泡+酶类心包腔内注射超声导入的方法可有效改善非病毒载体在体心肌的转染效率，同时具有一定的靶向性，但总的转染范围仍然有限；采用这一方法进一步进行&一肾一夹&心肌肥大模型大鼠在体心肌细胞的CaNAβ的RNAi干预，发现心肌肥大大鼠心外膜下局部心肌细胞CaN Aβ蛋白水平降低，CaN AβmRNA水平虽有下降趋势，但无统计学差异，提示质粒的用量及超声导入的参数有待进一步研究使其优化。

Results: The age of onset, the proportion of smoke, the proportion of cough, expectoration, polypnea, cyanosis, rhonchi and moist rale in two lungs were higher in OS patients than OSAS group, the level of body mass index, neck circumference, the proportion of polypnea, nighttime snore, nighttime apnea, daytime hypersomnolence were higher in OS patients than COPD group, the proportion of heart、pulmonary、kidney、 encephalopathy were higher in OS patients than OSAS group and COPD group, FVC, FEV1, FEV1/FVC, MVV, PaO2, SaO2 were lower in OS patients than OSAS group, FRC, PaCO2 were higher in OS patients than OSAS group, AHI was inversely related to the FEV1, FVC, MVV in Group OS, LSaO2 in Group OS was inversely related to the AHI.

结果：OS组的发病年龄、吸烟者比例、咳嗽咳痰、气促、紫绀、肺罗音比例均高于OSAS组，BMI、NC、夜间打鼾、夜间呼吸暂停、白天嗜睡的比例均高于COPD组；OS组合并心、肺、肾、脑等疾病的比例均高于OSAS组及COPD组；OS组的FVC、FEV1、FEV1/FVC、MVV、PaO2、SaO2的值均低于OSAS组，FRC、PaCO2均高于OSAS组；OS组AHI与FEV1、FVC、MVV呈负相关，LSaO2与AHI呈负相关，LSaO2与FEV1、FVC、MVV呈正相关；OS组的最长呼吸暂停时间、S1+2、NREM均高于OSAS组，而LSaO2、REM均低于OSAS组，AHI、最长呼吸暂停时间、S1+2均高于COPD组，LSaO2、S3+4均低于COPD组。

The two can cause ultrastructural pathogenesis widely in many organs and tissues such as hepar, pancreas, lien, ren, pulmo, cerebral, cerebellum, cor, muscular and so on, of them ,caused by i~olates YG97 and Y98 more obvious in epithelial cells of digestive tract and unobvious in epithelial cells of respiratory tract ,but ultrastructural pathogenesis caused by NDV strain F48E8 ,more obvious and more serious in glandularis and muscularis ventriaculi and in epithelial cells of respiratory tract .

将鹅源分离株YG_(97)、鸡源分离株Y_(98)和NDV强毒株F_(48)E_8感染SPF鸡，运用扫描电镜和透射电镜观察该二株病毒对机体细胞的影响，结果显示三株禽副粘病毒均引起机体肝、胰、脾、肾、肺、小脑、大脑、心和肌肉等实质器官组织细胞的超微病变，其中YG_(97)和Y_(98)引起消化道粘膜上皮细胞发生微绒毛脱落、纤毛脱落、分泌颗粒增多、细胞游离面破溃等显著的超微病变，引起气管粘膜上皮细胞的不显著超微病变；F_(48)E_8强毒株引起胃粘膜显著而严重的超微病变；还引起气管粘膜上皮严重的超微病变。

Background: New studies showed that changes in the balance between haemostatic and antithrombotic processes, including a prethrombotic state might contribute to the development of atherosclerotic lesions which occured in hypertensive vascular complications. This may be one of the causes that satisfactory blood pressure reduction with antihypertensive drugs does not lead to an equal reduction in heart attacks and strokes. With the development of traditional presentation of blood coagulation, the role of tissue factor pathway has been emphasized.

中文题名原发性高血压患者组织因子途径变化与血栓前状态关系的临床与实验研究副题名外文题名 Clinical and experimental study of relation between changes of tissue factor pathway and prethrombotic state in hypertensive patients 论文作者张卫茹导师孙明教授学科专业内科学研究领域\研究方向学位级别博士学位授予单位中南大学学位授予日期2002 论文页码总数70页关键词血栓组织因子高血压馆藏号BSLW /2003 /R544 /3 背景：新近的研究表明，凝血与抗凝系统失衡所导致的血栓前状态与高血压并发症的发生关系密切，这可能是高血压病人虽经有效的降压治疗但发生心、脑、肾、血管并发症的危险仍很高的主要原因之一。

Bitter medicinal herbs are for the heart, acidic herbs for the lungs and bronchial tube, and salty ones for the kidneys. As soon as one tastes it, one can get a general idea of whether the medicine obtained is the correct one.

大略地说，味酸的治肝脏，风疾，味甜的治脾胃，郁闷等病，味苦的治心，味辛辣的治肺，气管诸疾，味咸的治肾；把药汁一尝，马上可以试验出医生的药方，或药房抓的药，有没有被搞错。

The labia have now been sutured together almost completely.The drains and the Foley catheter come out at the top.

此刻阴唇已经几乎完全的缝在一起了，排除多余淤血体液的管子和Foley导管从顶端冒出来。

To get the business done, I suggest we split the difference in price.

为了做成这笔生意，我建议我们在价格上大家各让一半。