肾小球

Some recent researches of abroad have found bone marrow cells can also differentiated into glomeruli cells in some conditions, differentiated into intercapillary cells, endothelium or podocyte in different animal models, but these reports are rare in the domestic.

国外的一些研究表明，骨髓细胞在一定条件下还可以向肾小球细胞分化，在不同的动物模型中分化成为肾小球的系膜细胞、内皮细胞和足细胞，但国内却鲜有报道。

Results The model showed serious edema, proteinuria, hypoproteinemia, and hyperlipidemia. Podocytes were swollen and mesangial cells developed mild hyperplasia at the end of the fourth week. The nephric tubule atrophied at the end of the eighth week accompanied with adhesion between glomeruli and Bowman's capsule. Glomeruli sclerosis of mild or medium degree was observed at the end of the twelfth week with obvious lymphocyte infiltration in the renal interstitium as well as the formation of collagen fibers.

结果 该模型表现为严重水肿、大量蛋白尿、低蛋白血症和高脂血症；病理学检查显示，4周末肾小球足细胞肿胀，系膜细胞轻度增生；8周末有球囊粘连，肾小管上皮细胞萎缩；12周末部分肾小球节段性轻、中度硬化，间质内有明显灶性淋巴细胞浸润，并有轻度纤维化。

Results In the 102 males,84 females,who are average 13~65(30.7±13) years old,there are 76(41%) cases of nephrotic syndrome,59(32%) cases of chronic glomerulonephritis,41(22%) cases of latent glomerulonephritis,10(5%) cases of acute nephritic syndrome.

结果 本组资料中男102例，女84例，年龄13~65岁，平均(30.7±13)岁，其中肾病综合征76例，慢性肾小球肾炎59例，隐匿性肾小球肾炎41例，急性肾炎综合征10例；所占比例分别为41%、32%、22%、5%。

This study is to observe the effect of of Fluvastatin in adriamycin-induced nephropathic rats. Methods The 45 male rats were randomly divided into three groups:normal control group、non-treated nephropathy group、Fluvastatin-treated group.

本课题旨在通过阿霉素肾病大鼠肾小球硬化模型的建立，并应用氟伐他汀治疗，观察其对血脂、尿蛋白的影响，以及对促进ECM降解的基质金属蛋白酶-9(MMP-9)表达的影响，探讨氟伐他汀延缓肾小球硬化的作用机制。

Fluvastatin not only can decrease lipid and 24-hour urinary protein excretion in adriamycin-induced nephropathic rats, but also retard chronic progressive kidney damage by increasing expression of MMP-9 in renal tissues.

结论在阿霉素肾病大鼠肾小球硬化模型中，氟伐他汀具有降血脂、减少尿蛋白的作用外，还可以通过上调MMP-9在肾组织的表达和减少ECM积聚，延缓肾小球硬化的进展。

Results The according perception of Normocytic, Microcytic and Non-classified RBC between phase contrast microscope and UF-100 urine sediment analytic instrument RBC-info are 91.4%, 94.4%, 83.3% respectively, the according perception between phase contrast microscope and RBC-P70Fsc are 94.9%, 95.7%, 94.7% respectively, and the according perception between phase contrast microscope and RBC Fsc-DW are 84.4%, 86.8%, 90.5% respectively, the specificity of UF-100 and phase contrast microscope in glomerular hematuria and non-glomerular hematuria are 84.3%, 88.1% and 83.3%, 87.9% respectively.

结果 观察相差显微镜与流式细胞分析仪RBC-info尿红细胞均一型、变异型、混合型形态符合率分别为91.4%、94.4%、83.3%，与RBC-70Fsc符合率分别是94.9%、95.7%、94.7%，与RBC-Fsc-DW符合率分别是84.4%、86.8%、90.5%，流式细胞分析仪与相差显微镜的特异性在肾小球性血尿和非肾小球性血尿分别是84.3%、88.1%和83.3%、87.9%。

In this study, we evaluated pathology, cytoplasmic factor and the phenotypic transition of primary kidney cells in the glomerulosclerosis rats, to explore the mechanism of the glomerulasclerosis and the effects of Shenshuning of smoothing shaoyang and treating both the primar...

本研究从肾脏病理、细胞因子网络和肾脏固有细胞的表型转化方面等探讨肾小球硬化的病理机制和疏利少阳标本兼治法之肾疏宁对阿霉素肾小球硬化大鼠的作用和作用机理。

And the most severe pathological change was shown in patients of Speen –kidney Yang Deficiency , all grade 3 renal interstitial fibrosis belonged to it.

1、BMP-7表达与慢性肾小球肾炎肾间质纤维化程度有密切关系，它可以作为慢性肾小球肾炎肾间质纤维化程度的标志。

The relationships of VEGF with the indices of renal damage, including renal/body weight, urinary protein excretion, glomerular volume and glomerular area, were analyzed. Results The expression of VEGF mRNA in diabetic kidney was significantly up-regulated after operation from 2 weeks to 24 weeks with the peak level at 20weeks, when compared with control at the same time- points. The positive results of VEGF staining in diabetic glomeruli was increasingly observed after operation from 2 weeks to 24 weeks, with the peak at 20 weeks. The positive results of VEGF staining in diabetic tubuli was increasingly seen from 2 weeks to 24 weeks, with the peak at 8 weeks.

结果 VEGF mRNA在糖尿病模型组大鼠肾脏中持续高表达，各时点与对照组相比差异均有统计学意义(P.05)；糖尿病组2~24周肾小球VEGF蛋白表达强于对照组(P.05)，24周时有所减弱，但仍强于对照组；糖尿病组各时点肾小管VEGF蛋白表达均强于对照组(p.05)， 8周后表达明显增强；VEGF表达变化与肾质量／体质量(r=0.518， P＝0.001)、尿蛋白(r=0.409， p=0.001)、肾小球面积(r=0.499， P-0.000)和体积(r=0.499， P-0.000)呈正相关。

The therapeutic effect of HYJDT on glomerulosclerosis was observed by way of five aspects:(1) Effect on renal tissue morphology;(2) Effect on urine protein and blood creatinine and blood uria nitrogen ;(3) Effect on superoxide dismutase and malonydialdehyde in reual cortex;(4) Effect on matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-l (TIMP-1) in glomerulus;(5) Effect on MMP-9 mRNA and TIMP-lmRNA and type-1 plasminogen activator inhibitor (PAI-1) mRAN in glomerulus.

用药治疗12周取肾，HE、PAS染色，在光镜下观察肾组织形态学变化，并在透射电镜下观察肾小球超微结构的变化。用半自动生化分析仪检测肾皮质匀浆中SOD活力、MDA含量。用免疫组化技术检测肾小球中MMP-9、TIMP-1的蛋白表达，用原位杂交技术检测MMP-9mRNA、TIMP-lmRNA、PAI-lmRNA的基因表达。免疫组化和原位杂交结果，采用计算机图象分析系统测量各自的平均吸光度。所有的实验数据均用SAS6.12统计软件包进行统计学处理。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。