肾小球

This method could increase molecular weight of the medicamentous protein and decrease the immunogenicity of the heterogenesis protein, thereby it could diminish glomerular filtration rate and clearance rate in vivo.

该方法增大了蛋白药物的分子量，降低了异源蛋白的免疫原性，从而可以减少肾小球滤过率和体内清除率，有效提高IL-2在体内的半衰期，具有非常广阔的生产以及临床应用前景。

Under transmission electron microscope, cellular swelling in brain tissue, nuclear membrane of neuron has incisures, some chromatic agglutination, group A mainly appears endoplasmic reticulum distention and glial cell endocytosis, while group B mainly appears histolysis; cardiac fibrous structure is chaotic, Z line concentrates, mitochondria swelling, nucleus deform; the ecphyma of podocyte becomes thinner and longer like villus, some mix together, plasma membrane infolding of renal cells decreases, mitochondria malformation, cells in lumens.

透射电镜观察显示，试验组动物脑组织细胞肿胀，神经元核膜出现切迹，部分染色质凝集，A组动物出现内质网扩张及胶质细胞吞噬现象，B组动物以组织溶解为主；心肌纤维结构紊乱，Z线聚集，收缩带形成，线粒体肿胀，核变形；肾小球足突细长，绒毛化，并可见足突融合，肾小管上皮细胞质膜内褶减少，线粒体畸形，管腔可见脱落细胞，上述改变均以B组为著。

Objective To investigate the effect of rapamycin on cholesterol homeostasis of glomerular mesangial cells and the underlying mechanism.

目的 研究雷帕霉素对炎性反应状态下肾小球系膜细胞内脂质稳态的影响及探讨其可能机制。

Results: Compared with control group, the level of Glu, KW/BW, 24 hUP, Scr, UPC in DN group were significantly increased. The expression of Ezrin in glomeruli statistically decreased.

结果：与对照组相比，DN组Glu、KW/BW、24 h UP、Scr、UPC显著升高；肾小球Ezrin表达显著下降，足细胞数目减少。

Renal glomeruli had hyaline changes suggestive of an immunologic process.

肾小球有表明免疫学过程的玻璃样变化。

Methods Expression of bFGF mRNA and protein were examined by in situ hybridization and immunohistochemical staining.

探讨碱性成纤维细胞生长因子在人类增殖性肾小球肾炎中的表达及作用。

Methods The thickness of retinal capillary basement membrane and glomerular basement membrane and their anionic sites were quantitatively analyzed by electron microscopy and immunohistochemical methods.Results RBM and GBM became gradually thickened with the development of diabetes. The thickened basement membrane was accompanied with decrease of anionic sites in number.Conclusion DR and DN share partly the pathological process, and there are also some incoordinate phenomena in the microvascular lesion.

我们采用普通电镜和免疫组化电镜等方法对糖尿病动物模型进行了系统观察，着重对比分析视网膜和肾小球微血管病变，试图寻找DR和DN的相关性，以期阐明其发生、发展的规律，为临床探索或延缓糖尿病患者并发DR或DN的手段提供理论依据。

Results: Expression of PAI-1, TIMP-1 and FN in kidney of diabetic rats began to increase in the second week of diabetes; PAI-1 and TIMP-1 mainly expressed in intracytoplasm of renal tubular epithelial cells, while FN mainly expressed in renal tubule matrix and glomerului; Their expression showed a tendency of increasing along with the progression of diabetes.

结果：PAI-1、TIMP-1及FN表达从糖尿病2周起较正常对照组明显增多(P.01)，PAI-1和TIMP-1阳性表达主要位于肾小管上皮细胞胞浆内，FN阳性表达主要位于肾小管间质和肾小球，且随着糖尿病进展有逐渐增加的趋势。

Objective: To investigate the role of intercellular adhesion molecule-1(ICAM-1) in glomerular inflammation and effects of losartan on it.

目的：探讨细胞间粘附分子-1（ICAM-1）在肾小球炎症过程中的作用及氯沙坦对其影响。

Results In the ANCA negative group, 2 cases were without malignant hypertension ,1 was acute tubular necrosis caused by herbs, 6 were scleroderma renal crisis, including 4 with renal biopsy, indicating hypertrophic arterial media, edema, thickened intima, onion- skin lesion in interlobular arteries and afferent arterioles, as well as ischemic lesion in glomeruli.

结果 11 例SSc急性肾损伤患者中，ANCA阴性9 例，6 例临床表现为硬皮病肾危象，其中4 例肾活检示小叶间动脉和入球小动脉内皮细胞增生、肿胀，内膜黏液性水肿，内弹力纤维断裂，"洋葱皮样"改变和肾小球弥漫性缺血；无恶性高血压表现2 例；急性肾小管坏死1 例。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐