肾小体

Results Growth and differentiation occurred and mature renal corpuscle emerged for seperated metanephroi by both histoculture and transplantation.

供体后肾肾小体出现之前是移植的最佳时间；后肾移植物内的毛细血管袢是由其自身的间质细胞分化而来的。

The cell body was from column to thin and flat form, cell gibbosity grew out of nothing and changed from small quantity to large quantity, the extracellualr space expanded from small to large.

随着发育过程中形态的变化，上皮细胞逐渐参与了肾小体滤过屏障的组成。

The kidney is composed of renal corpuscle , neck segment , proximal tubule, middle segment, distal tubule and collecting tubule.

肾脏由肾小体、颈段、近曲小管、中间段、远曲小管和收集管6部分构成，肾小体由肾小球和肾小囊组成，在肾小体附近可见致密斑样结构，未见髓袢结构。

The results showed that , the ratio of thickness of the renal cortex to the medulla in Felis bieti is 1∶2.35, the ratio of the number of the proximal tubule to the distal convoluted tubule in the cortical labyrinth in Felis bieti is 2.26∶1, the density of the renal capsule in the cortex deep layer is bigger than that of the shallow layer, the number of the thin segment is high both in the medulla and medullary ray.

结果显示：荒漠猫肾脏皮质与髓质的厚度比为1∶2.35，皮质迷路内近曲小管与远曲小管的断面数量比为2.26∶1，皮质中肾小体的分布密度近髓大于浅表，髓放线和髓质中细段分布较多。

Cases healthy subjects served as control. In addition, density of glomerular matrix membrane and quantity of cell in glomeruli were measured with CMIAS image analysis system by computer. Global sclerosis, cellular crescents, fiber or fibrocellular crescents were measured with Memphis scope. Tubulointerstitial lesions were examined with semi-quantitative grades (including O-III grades).Results Compared to normal control, there was a significant increase of urinary TGF-betaK IL-6 and Col-lV levels in patients with IgAN (p. 01). There were also significantly positive correlation between the levels of urinary TGF-betaK Col-IV and density of glomerular matrix membrane ., interstitial fibrosisp.

采用酶联免疫吸附法测定尿TGF-β1(Transforming growth factor-β1)、尿IL-6(interleukin-6)和尿Col-Ⅳ(type Ⅳ Collagen)；采用免疫组织化学法检测肾组织TGF-β1、Col-Ⅳ表达；应用CMIAS多功能真彩色病理图像分析系统对肾小球基质基底膜面密度和细胞个数进行半定量测定；对球性硬化、节段硬化、细胞新月体及纤维或纤维细胞新月体所占肾小球百分数和肾小球IgA沉积免疫荧光强弱的判断采用Memphis法进行评分；肾小管间质病变程度采用光镜下半定量分级法(包括0-Ⅲ级)。

Theurinary IL-6 level positively correlated with density of glomerular matrix membrane, global sclerosis, fiber or fibrocellular crescents and interstitial fibrosis (p. 05). According to the degree of density of glomerular matrix membrane and interstitial fibrosis, urinary Col-IV level had better correlation than urinary TGF-betal and IL-6 levels.In IgAN, Col-IV showed increased expression in diseased renal tissue whereas the site of expression of TGF-betal was mainly localized within the cytoplasm of tubular epithelial cells. Interstial expressionwas also present but glomerular TGF-betal expression was found only in patients with heavy mesangial proliferation. There was a significant correlation between glomerular positivity for Col-IV and severity of histological damage. There was also a significant correlation between positivity for TGF-betal and Col-IV in the tubular epithelial and interstitial lesions. In contrast, there was no ralationship between glomerular positivity for TGF-betal and severity of histological damage.The urinary TGF-betal level paralleled tubular TGF-betal expression.

结果 ①IgAN患者尿TGF-β1、IL-6、Col-Ⅳ水平较健康人明显增高(P＜0.01)，该变化与血中的浓度无关(P＞0.05)；②尿TGF-β1水平与小管间质TGF-β1阳性表达呈正相关(P=0.000)，而与小球TGF-β1阳性表达无关(P＞0.05)，尿Col-Ⅳ水平与小球和小管间质Col-Ⅳ阳性表达均呈良好的相关性(P＜0.01)，还与小管间质TGF-β1阳性表达呈正相关(P＜0.05)：③小球Col-Ⅳ阳性表达与肾组织慢性病变密切相关(P＜0.05)，小管间质Col-Ⅳ和TGF-β1阳性表达均与肾小管间质病变呈良好的相关性(P＜0.01)，而小球TGF-β1阳性表达与肾组织损伤无关(P＞0.05)；④尿TGF-β1、Col-Ⅳ水平与肾小球基质基底膜面密度、小管间质病变呈正相关(P＜0.01)，与小球内细胞数呈负相关(P＜0.05)，该结果与其在组织中的表达一致；尿IL-6水平浙江大学硕士学位论文尿TGF一B一、IL一6和Col一IV在IgA肾病中的应用价值与基质基底膜面密度、球性硬化、纤维或细胞纤维新月体所占肾小球百分数及小管间质病变均有显著的相关性(F.05)；在轻度肾病理损伤时，尿'l'G卜pl、I卜6、Col一IV水平即升高，而尿Col一W在反映细胞外基质积聚和间质纤维化程度上比尿TGF一pl和IL一6有更好的相关性。

Glomerular changes are both frequent and severe.

肾小体的病变是常见而严重的。

Suis was found in all identifiable crypt areas; SS2 also appeard in marginal zone and periarterial lymphoid sheath of spleen, hepatic sinusoid of liver, interstitium of lung; presence of SS2 was at the cortex where histopathological lesions and expression of inflammatory mediators were observed.

实验表明，SS2主要定殖于扁桃体的隐窝附近；在脾的边缘区和动脉周围淋巴鞘附近、淋巴结的生发中心和皮质内、肝血窦、肺间质和肾小体中均可见菌体状荧光颗粒；在脑组织中发生脑膜炎的区域，如皮层等可检出细菌。

Objective: To explore morphological origin during the development of rat renal corpuscles.

目的：探讨大鼠肾小体发生发育过程中的形态变化规律。

Methods: Light and electron microscopy combined with stereology methods were used to investigate the rat renal corpuscles at different growing stages.

采用光镜、电镜技术并结合体视学测量方法，对不同发育阶段大鼠肾小体进行形态观察和体视学计量。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。