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肾上腺素

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The hemodynamic changes after peritoneal insufflation of CO2 were measured with Swan-Ganz catheterization,and the plasma concentration of epinepherine and nonepinepherine were measured before and after CO2 being insufflated into peritoneal cavity with high performance liquid chromatography-electrochemical method.

20例行腹腔镜胆囊切除患者,随机分成全麻组(A组,11例)和硬膜外+全麻组(B组,9例),采用Swan-Ganz导管技术,监测气腹时血液动力学变化,用高效液相色谱——电化学检测气腹前后血浆肾上腺素和去甲肾上腺素浓度。

HR、MAP、ECG、SPO_2、PETCO_2 and Ppeak were monitored and the venous blood samples were obtained to measure serum concentrations of epinephrine, NE, IL-6 and IL-10 by ELISA at different perioperation time: 5 min before anesthesia (T_0), before the CO_2 was insufflated into peritoneal cavity (T_1)and 5 minutes after(T_2),20 minutes after(T_3), the end of peritoneal insufflation (T4)and 30 minutes after the end of peritoneal insufflation(T_5). Blood samples from artery were obtained atT_1、T_2、T_3、T_4、T_5 for blood gas analysis.

于麻醉前5min(T_0)、气腹前5min(T_1)、气腹开始后5min(T_2)、气腹开始后20min(T_3)、气腹结束时(T_4)及气腹结束后30min(T_5),抽静脉血标本,分离血浆,用ELISA法测肾上腺素、去甲肾上腺素、细胞因子IL-6、IL-10浓度,并于T_1、T_2、T_3、T_4、T_5各时点抽动脉血行血气分析。

To determine whether α1 and α2-adrenoceptors are located postsynaptically on renal vascular smooth muscle, a new method was developed as the following: the right renal vascular beds in the pithed rats were perfused with blood drawn from carotid artery at constant rate by a pump.

本实验用颈动脉血恒速满流毁脑脊髓大鼠单侧肾脏的方法,观察了高度选择性α_1受体阻断剂哌唑嗪和α_2受体阻断剂育亨宾与去甲肾上腺素肾上腺素及电刺激肾交感神经对肾血管平滑肌的相互作用。哌唑嗪明显抑制电刺激引起肾灌流压升高,但尚存留一小部分既不能被增加哌唑嗪的剂量所阻断也不能被育亨宾所阻断。

Norepinephrine ; epinephrine ; prazosin ; yohimbine ; pithed rat ; renal blood vessel perfusion ; electric stimulation ;α1 and α2receptors

去甲肾上腺素肾上腺素;哌唑嗪;育亨宾;毁脑脊髓大鼠;肾血管灌流;电刺激;突触后膜α_1和α_2受体

Beta blockers halt this process by blocking adrenaline receptors and slowing the heart rate.

beta-受体阻断剂通过阻断肾上腺素受体而阻断肾上腺素的这种正性肌力作用,减缓心率。

Epinephrine, also called "adrenaline," is the medication of choice for controlling a severe reaction.

肾上腺素,也称&肾上腺素&是一个严峻防治用药选择反应。

Kg or less: Consider use of ampule of epinephrine with needle and syringe to draw correct dose (0.01 mg/kg) of epinephrine.

10kg及以下:考虑使用肾上腺素安瓿,用注射器和针头抽吸肾上腺素正确剂量(0.01 mg/kg)。

2AR knockoutmice and wild-type congenic FVB/N controls were studied, aswell as 2 groups of wild type mice given either ICI 118,551(0.2 mg/kg) or 0.9% saline intraperitoneally 30 min before MCAO( n = 10 per group).

大鼠分为两组,分别为β2-肾上腺素能受体缺乏小鼠及野生型同类系小鼠作为对照组,两组野生型小鼠在 MCAO 30分钟前分别腹腔内随机注射选择性β2-肾上腺素能受体阻滞剂 ICI118,551(0.2mg/kg )或0.9%生理盐水(每组 n=10)。

Results: It is showed that Xiaokeping Jiaonang is a effective prescription in treating diabetes mellitus by the experiment. The prescription could be anti- hyperglycaemia which is caused by adrenaline and increase the content of hephormone of Jimpy mice, and has positive curative effect in treating rabbit of Diabetes mellitus which is caused by alloxan by improving blood rheology and Ang of biochemistry etc.

消渴平胶囊能够对抗肾上腺素引起的小鼠高血糖,增加其肝糖原的含量;改善四氧嘧啶性糖尿病家兔的一般状况,增加体重,降低血糖,改善血液流变学,纠正脂质代谢紊乱,增强SOD的保护作用,对肾上腺素引起的高血糖小鼠和四氧嘧啶所致的糖尿病家兔具有肯定的防治疗效。

Results In 3T3-L1 adipocytes, isoproterenol at the concentration of 10 μmol/L reduced the adiponectin secretion and insulin at the concentration of 5 nmol/L could block the inhibitory effect of isoproterenol. In 313-Li adipocytes expressed myrAkt, adiponectin secretion decreased significantly, isoproerenol treatment increased adiponectin and insulin couldn't block the effect of isoproterenol.

结果 异丙肾上腺素可明显降低3T3-L1脂肪细胞脂联素的蛋白质表达,胰岛素可纠正这一变化;表达myrAkt的3T3-L1脂肪细胞中脂联素明显减少,异丙肾上腺素可增加脂联素蛋白的表达,胰岛素不能纠正这一变化。

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