肽

Adopt Fmoc solid-phase synthesis method to synthesize the linear peptide,and use DCC-HOBT method to cyclize the antamananide the result of study shows: the resulting that the linear peptide is 64%,the purity is 95%;the content of Antamananide is above 25% in the products.

采用Fmoc固相合成法合成直链多肽，并用DCC-HOBT环化法合成了抗鹅膏肽，结果表明：所得的直链多肽收率为64%，纯度为95%；所得的环化产品中抗鹅膏肽的含量在25%以上

Cefaclor is a kind of cephalosporin antibiotics which is extensively used for anti-infection. It will devitalize transpeptidase, disturb the final step synthesis of the cell wall and prevent the cross bonding of mucopeptide.

头孢克洛是广泛应用于抗感染的头孢菌素类抗生素药物，它的杀菌作用是使转肽酶失活，干扰细菌细胞壁最终阶段的合成，阻止粘肽原的交联。

While the PNA is neither classical nucleotide nor classical protein, and can resist the discomposing of nuclease and proteinase.

肽核酸与双螺旋脱氧核糖核酸更易形成三螺旋的一个重要原因是肽核酸不带净电荷。

E. , ACTH antagonizes the analgesia mediated byμand δ opioid receptors, but notκreceptor;(2) The antagonizing effect of ACTH on opioid analgesia is proposed to be mediated by ACTH receptors, although the latter has not been characterized;(3) A contradictory interaction on intracellular cAMP content may constitute one of the postreceptor mechanisms underlying ACTH antagonism of opioid analgesia;(4) Another proposed mechanism of the anti-opioid effect of ACTH is that ACTH can modulate opioid-induced suppression of calcium influx;(5) ACTH has been shown to induce Fos protein expression in selected areas of the rat brain including the nuclei involved in pain regulation as well as the ependyma of the third ventricle and the aqueduct.

根据以上实验结果，本论文首次提出以下论点：（1）ACTH在脊髓水平对抗阿片镇痛具有受体选择性，即ACTH可对抗μ受体和δ受体介导的镇痛，不对抗κ受体所介导的镇痛；（2）由于ACTH与阿片μ受体的肽类配体的结合位点仅有很低的亲和力，与μ受体的非肽类配体的结合位点以及δ受体无亲和力，推测ACTH是通过中枢内的ACTH受体介导发挥抗阿片效应的；（3）ACTH抗阿片作用的受体后作用机制之一是在cAMP信使通路水平与阿片发生相互作用；（4）ACTH抗阿片作用的另一受体后机制是在〓水平影响阿片的效应；（5）通过Fos蛋白的诱导揭示：ACTH可以作用于脑内多个核团，其中包括许多与痛觉调制有关的核团，推测ACTH可能通过激活这些核团的神经元而发挥其中枢效应。

Complete acid hydrolysis of the peptide followed by amino acid analysis yielded equimolar amounts of Leu, Orn, Phe, Pro, and Val. Orn is ornithine, an amino acid not present in proteins but present in some peptides .

此肽完全水解，然后经氨基酸分析产生等摩尔的Leu，Orn，Phe，Pro和Val，Orn为鸟氨酸，是蛋白质中不存在而存在于某些肽中的一种氨基酸。

To synthesize the octreotide, Phe-Leu-Glu-Glu-Leu and C_(15)H_(31)-CO-Lys-Thr -Thr-Lys-Ser peptides, the strategies are as followings: Fmoc- group as protective group for α-NH_2; TBTU, DIEA and HOBt as coupling reagent; and ethanedithiol -phenol - thioanisole - H_2O - TFA ( 2.5:5:5:5:82.5 , V/V ) as cleaving solution.

采用Fmoc固相合成法，以苯并三哗四甲基脲四氟硼酸盐、二异丙基乙胺和1-羟基苯骈三氮唑为缩合剂；苯酚—乙二硫醇—苯甲硫醚—水—三氟乙酸(5：5：2.5：5：82.5，V/V)为切割试剂，合成了奥曲肽、Phe-Leu-Glu-Glu-Leu及C_(15)H_(31)-CO-Lys-Thr-Thr-Lys-Ser三种小分子多肽，并对奥曲肽的合成规模进行了放大。

The structure-activity relationship of DSIP and con formational study of this peptide in solution were also presented.

概述了Delta－诱眠肽的构效关系及溶液构象的研究进展，展望了Delta－诱眠肽的研究方向。

Stein I A%Svein J H%Vincent G H Enzymatic hydrolysis of Atlantic cod(Gadus morhua L.)viscera 10.1016/j.procbio.2004.07.011 Process Biochemistry , 2005,null

汪涛%曾庆祝%谢智芬内肽酶与端肽酶水解扇贝边蛋白质工艺的研究大连水产学院学报， 2003，2

Administration of methotrexate to rats caused severe enterocolitis with 66. 7% and 16. 7% mortality within 72 hours in the first group and the second group (2% Gln), respectively. But the sucrase and aminopeptidase activities, protein content, DNA and RNA content of small intestine in rats of group 3 and group 4 were significantly higher than those in rats of group 1 and group 2. These meant that GEON enhanced digestion processes, so it can be used to improve nutritive conditions of the small intestine.

用氨甲蝶呤诱发小肠炎后，分别饲喂Gln含量不等的氨基酸营养液，实验结果表明，氨甲蝶呤诱发的小肠炎是一种较严重的应激状态，在72小时内，零剂量组大鼠的死亡率高达66.7％，2％Gln组的死亡率为16.7％，其它测定指标也相对较低，说明对小肠炎模型而言，营养液中2％的Gln含量可能偏低，第三组和第四组（结晶氨基酸组，Gln含量同第三组）的死亡率为零，体重有所恢复，蔗糖酶活、氨肽酶活、DNA和RNA含量增加，这说明，Gln活性肽营养液对小肠炎具有一定的治疗作用，可作为小肠损伤后的辅助治疗药物。

SPWSG contains α-glucosidic bonds;furthermore the type of the glucosidicbonds was pyranose;protein was covalently linked with carbohydrate by O-glycosyllinkage.

红外光谱和β-消去反应表明：甘薯糖蛋白中含有α-糖苷键，糖苷类型主要为吡喃型；糖与蛋白的肽链之间的连接点类型是O-糖肽键。

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。