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Results AQP1 is expressed at the apical and basolateral membrane of the microvascular endothelium; AQP3 was detected at basal cells of both the bronchiole epithelium and submucosal gland acinus; AQP4 is present in the basolateral membrane of columnar cells in bronchiole; while AQP5 is expressed in the apical membrane of type Ⅰ pneumocytes, and also at the apical of columnar cells of superficial epithelium and submucosal gland acinar cells.

结果本研究发现AQPs基因在羊肺中的表达分布与人相似,AQP1在肺内的毛细血管内皮细胞表达;AQP3在小支气管黏膜上皮的基底细胞的基侧膜表达,AQP4存在于小支气管黏膜上皮的柱状纤毛细胞的基侧膜;AQP5存在于Ⅰ型肺泡上皮细胞的顶质膜,存在于小支气管黏膜上皮柱状纤毛细胞,以及在气道黏膜下腺的腺细胞的顶质膜表达。

Ping chuan-fang prescription is carefully composed accordingly. The clinical investigation shows that PCHF can not only alleviate symptoms and physical sign of the patients effectively, but also shorten the course of disease and obviously can not only alleviate symptoms and physical sign of the patients effectively, but also shorten the course of disease and obviously improve the pulmonary function of the patient. The animal experiment showed that PCHF can prolong the asthmatic time and low the concentration of WBC, EOS, IL-4, ET-1 in the blood and BALF. It can restrain the collection of EOS in the lung and relieve the inflammation caused by EOS. It also can cut down the secretion of the respiratory air-way and relieve the obstruction of it.

动物实验表明:平喘方能明显延长卵蛋白造模大鼠的引喘潜伏期,且与氨茶碱对照有非常显著性差异(P<0.01);能降低哮喘模型大鼠血浆及肺泡灌洗液中白细胞、嗜酸性粒细胞及IL-4、ET-1的含量;能抑制肺局部EOS的聚集,明显减轻由EOS浸润引起的慢性变应性炎症反应;能减少气道分泌物,减轻细支气管及小血管管壁的增厚,减轻周围组织的水肿,从而减轻气道的阻塞,最终改善肺通气,缓解喘息症状。

In nonsmokers without pulmonary disease at baseline, there were no severe decreases in lung function attributed to Exubera, and high-resolution chest computed tomography revealed no evidence of notable lung changes. Completed phase 2 and 3 studies that followed patients for up to 4 years indicate that the differences over time in pulmonary function changes between patients treated with Exubera and control patients are small, nonprogressive, clinically insignificant, and reverse after discontinuation of Exubera therapy.

Feb。 9, 2006 --尽管一开始对於肺功能影响的顾虑,美国食品药物管理局仍然批准辉瑞药厂生产的吸入性胰岛素Exubera使用於成人第1、2型糖尿病;该核准案於1月27日通过,也就是欧盟核准该药物上市后隔天;自从胰岛素於1920年代被发现以来,吸入型粉状的基因重组人类胰岛素是第一个新的胰岛素投与选择;临床试验数据显示,使用exubera一开始会使肺功能下降,但是并非进行性的,其效果与一般胰岛素相当,而且具有病患顺从性较高的优点。

①The key of success is using the sharp incision biopsy needle and choosing the place of focus denseness to incise.②The key to reduce the complication is using"3 quick"means.③Pulmonary percutaneous biopsy is a diagnostic measure of permeative pathological changes in lung.

(1)使用锋利的切割针、选择病灶密集的部位切割是取材成功的关键;(2)采用快进快出快切割的&三快&操作方法是减少并发症的关键;(3)经皮肺穿刺切割活检是肺内弥漫性病变可以选择的一种确诊方法。

Results: The primarily incipient symptoms of MCTD were Raynauds phenomenon, the next symptoms were febrile、 arthralgia/ arthritis and myositis. Myositis and sclerodactyly/finger swollen were easy to be seen in patients with pulmonary artery hypertension / pulmonary interstitial fibrosis.

结果:MCTD最常见的临床表现为雷诺现象,其次为发热、关节肿/痛和肌炎,有肺间质病变朋市动脉高压的患者肌炎和硬指/手指肿胀的出现率高;对于MCTD患者,需早期进行肺部HRCT的检查,排除有无肺间质病变的出现。

Up to now however, there has been no evidence that PET leads to improved management of patients in routine clinical practice. We did a randomised controlled trial in patients with suspected non-small-cell lung cancer, who were scheduled for surgery after conventional workup, to test whether PET with 18FDG reduces number of futile thoracotomies.

首先,在原发瘤的评估方面,其作用目前仅限于对单发肺内结节的良恶性鉴别,并且阳性预测值相对较低,在肿瘤可切除性评估方面的作用远逊于CT;更何况肺内良性肿瘤也需要手术切除,而那些不需要手术的病灶,比如活动性结核瘤及炎性肿物,PET 的假阳性率又太高。

The results showed that the sheep had fibrinous pneumonia and lymphocyte interstitial pneumonia, which were typical pathologic changes of this disease. Remarkable changes were observed in the lung: fibrinous exudates, infiltration of inflammatory cells, pleura thickening, interstitial edema, hemorrhage and formation of thrombiand lymph clot. The heart, liver and kidney had different degeneration degree. Reactive hyperplasia presented in bronchales lymphonodi.

结果发现该病例具有胸膜肺炎的典型病理变化,呈现纤维素性肺炎和淋巴细胞性间质肺炎,纤维素性物质的渗出和炎性细胞的浸润很明显,肺胸膜增厚,同时在肺间质还可见水肿、出血、血栓和淋巴栓的形成;另外心、肝、肾也均有不同程度的变性,淋巴结呈反应性增生。

Results: The age of onset, the proportion of smoke, the proportion of cough, expectoration, polypnea, cyanosis, rhonchi and moist rale in two lungs were higher in OS patients than OSAS group, the level of body mass index, neck circumference, the proportion of polypnea, nighttime snore, nighttime apnea, daytime hypersomnolence were higher in OS patients than COPD group, the proportion of heart、pulmonary、kidney、 encephalopathy were higher in OS patients than OSAS group and COPD group, FVC, FEV1, FEV1/FVC, MVV, PaO2, SaO2 were lower in OS patients than OSAS group, FRC, PaCO2 were higher in OS patients than OSAS group, AHI was inversely related to the FEV1, FVC, MVV in Group OS, LSaO2 in Group OS was inversely related to the AHI.

结果:OS组的发病年龄、吸烟者比例、咳嗽咳痰、气促、紫绀、肺罗音比例均高于OSAS组,BMI、NC、夜间打鼾、夜间呼吸暂停、白天嗜睡的比例均高于COPD组;OS组合并心、肺、肾、脑等疾病的比例均高于OSAS组及COPD组;OS组的FVC、FEV1、FEV1/FVC、MVV、PaO2、SaO2的值均低于OSAS组,FRC、PaCO2均高于OSAS组;OS组AHI与FEV1、FVC、MVV呈负相关,LSaO2与AHI呈负相关,LSaO2与FEV1、FVC、MVV呈正相关;OS组的最长呼吸暂停时间、S1+2、NREM均高于OSAS组,而LSaO2、REM均低于OSAS组,AHI、最长呼吸暂停时间、S1+2均高于COPD组,LSaO2、S3+4均低于COPD组。

The metabolism of plasma ANP in lung increases in patients with left to right shunt C.H.

①左向右分流的先心病患者血浆ANP在肺部的代谢量增加,可能用于发挥其扩张血管、支气管等作用,但在不同程度肺高压时,其代谢量有差异,提示ANP在肺部的代谢可能与肺高压的形成有一定的关系。

The use of binomial nomenclature for human pneumocystis may be of less importance currently, given that visualization of the organism is required for the diagnosis of pneumonia.42,43 When PCR has been applied to pneumocystis pneumonia in humans, only P. jirovecii has been found, and for that reason, specifying the name of the species will become important only if additional species of pneumocystis are found to infect humans.

使用二项式命名为人类卡氏肺孢子可能不太重要,目前,由于可视化的生物体是所需的诊断pneumonia.42 , 43时, PCR技术已应用于卡氏肺炎在人类中,只有第jirovecii已发现,并基于这个原因,指明该人的姓名的物种将成为重要的,只有如果额外种卡氏肺孢子被发现感染人类。

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