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In this paper, statins pleiotropism at radiation-induced lung injury, lung tumor, pulmonary hypertension, pulmonary fibrosis, acute lung injury, chronic lung injury and other lung diseases will be reviewed.

本文综述了他汀类药物的多效性在放射性肺损伤、肺肿瘤、肺动脉高压、肺纤维化、急性肺损伤、慢性肺损伤等肺疾病中应用的研究进展。

There were high density images shaped as rope and slip in lungs of model control group rats and the pleura near the images were a little thickening. In MTX treated group, there were high density images shaped as slice along pulmonary veins. The veins of the blood vessels were obscure and the edges were unclear. In TPT treated group,there were multiple high density images shaped as tubercle and slice and the boundary were not clear. In XFC treated group, the lungs' outlines were clear and the veins were welldistributed. High density images shaped as spot were found in part lungs.

结果:HRCT表现为模型对照组大鼠肺轮廓欠清晰,肺部血管影扩张,边缘模糊且不规则,两肺有索条状密度增高影,邻近胸膜轻度肥厚;甲氨喋呤组大鼠肺部可见沿着肺纹理分布的斑片状密度增高影,肺血管纹理模糊,边缘不清楚;雷公藤多苷片组大鼠两肺可见多发性结节状及斑片状密度增高影,境界欠清晰;新风胶囊组大鼠肺轮廓清晰,肺纹理分布均匀,部分肺组织显示斑点状密度增高影。

The distribution was different in various multiple cavitary lung diseases.Local multiple onset was particularly prevalent in cavitary pulmonary tuberculosis,scattered multiple onset was particularly prevalent in various infected cavitary lung diseases,diffuse multiple onset was particularly seen in cavitary pulmonary metastases.

多发性肺空洞病变的肺内分布形式不同,局部多发多见于结核性肺空洞病变,散在多发多见于感染性肺空洞病变,弥漫多发多见于肺转移瘤空洞。

Results The CT findings of pulmonary distomiasis included:(1)unilateral or bialteral mottling,patchy and nodular shadows with hazy border.

结果 肺吸虫病肺内CT表现包括:(1)单侧或双侧肺野出现斑片状、结节状影,边缘模糊,部位、状态易变,少数病例可见特征表现的&隧道&征;(2)肺门影增大,肺纹理紊乱或病灶呈成簇状窟穴状影;(3)胸腔积液常见,特征表现为交替性胸腔积液和心包积液。

X displays right pulmonary tuberculosis accounted for 30.4% the left lung accounted for 18.8% the double lung accounted for 50.8% between the lung nature venereal diseases changes the performance is two lung textures increases thickly the edge is fuzzy the lung hilus increases the disorganization accounted for 62.3%; The lobulous lung essence infiltration pathological change performance is in two lungs retires the inner tube spot laminated shape and the cloud cotton wool shape shadow the focus of infection fusion may assume the ground glass density to account for 30.5%; The lung section substantive infiltration pathological change displays for the boundary clear triangle or the fan-shaped big laminated high density was 7.2%.

胸部X线表现右肺病变者占30.4%,左肺占18.8%,双肺占50.8%,肺间质性病变表现为两肺纹理增粗,边缘模糊,肺门增大,结构紊乱占62.3%;小叶性肺实质浸润病变表现为两肺中、下野内带斑片状及云絮状阴影,病灶融合可呈磨玻璃密度占30.5%;肺段实质性浸润病变表现为边界清楚的三角形或扇形大片状高密度阴影占7.2%。

X displays right pulmonary tuberculosis accounted for 30.4% the left lung accounted for 18.8% the double lung accounted for 50.8% between the lung nature venereal diseases changes the performance is two lung textures increases thickly the edge is fuzzy the lung hilus increases the disorganization accounted for 62.3%; The lobulous lung essence infiltration pathological change performance is in two lungs retires the inner tube spot laminated shape and the cloud cotton wool shape shadow the focus of infection fusion may assume the ground glass density to account for 30.5%; The lung section substantive infiltration pathological change displays for the boundary clear triangle or the fan-shaped big laminated high density was 7.2%.

结果 7个月~1岁发病例数占4.3%;1~3岁占17.4%;4~7岁占46.4%;8~13岁占31.9%。咳嗽占100%;发热占63.8%;56.5%无肺部体征。胸部X线表现右肺病变者占30.4%,左肺占18.8%,双肺占50.8%,肺间质性病变表现为两肺纹理增粗,边缘模糊,肺门增大,结构紊乱占62.3%;小叶性肺实质浸润病变表现为两肺中、下野内带斑片状及云絮状阴影,病灶融合可呈磨玻璃密度占30.5%;肺段实质性浸润病变表现为边界清楚的三角形或扇形大片状高密度阴影占7.2%。

Histomorphometric studies were done to measure the following indexes: the IOD values of pulmonary, skeletal muscular and pleural small vascular walls from staining of AT1 and AT2 receptors, the pulmonary vascular density, muscularization of the nonmuscular vessels, percent wall thickness and proliferation of pulmonary small vascular walls.

结果:先心病患儿肺小血管壁AT1、AT2受体染色的IOD值均高于对照组(P=0.000);先心病患儿骨骼肌和胸膜小血管壁AT1、AT2受体染色的IOD值均高于肺小血管(P<0.05);先心病患儿肺小血管壁AT1受体染色的IOD值与肺血管密度、非肌性肺血管肌化程度、肺小血管壁厚百分比和肺小血管壁细胞的增殖度相关(r分别为-0.783、0.742、0.521、0.657),AT2受体仅与肺血管密度和血管壁厚百分比相关(r分别为-0.487、0.516)。

The contents of mineral elements, like Fe, in LMTCMs were higher than that of nor-LMTCM. The result of analysis of mineral element of 14 LMTCMs by ICP-MS method also showed the content of Fe have something to do with lung meridian tropism effects. The result of the study of platycodon radix approved the laws too. These laws were used to predict if the marine medicines have the lung meridian tropism effects.2. The Compatibility laws of Medicines and their chemical composition in LSP were studied by mining the data of the constituent herbs and their chemical composition. The results showed that the most constituent medicines of lung system prescriptions have lung meridian tropism. Radix glycyrrhizae, herba ephedrae, semen armeniacae amarum, fructus schisandrae Chinese and their compatibility are common in lung system prescriptions. Terpene, alkaloid, steroid, and flavanoid compounds and their compatibility are common in lung system prescriptions.3. The marine phycophyta medicines of LSP were studied by the same method.

对比归肺经中药及肺系方剂主要化学成分构成,萜类、生物碱、甾体类成分可能是归肺经中药及肺系方剂的主要药效成分;结合君臣佐使药的化学成分构成特点及肺系方剂组成中药的归经构成情况,肺系方剂组方设计应该考虑以下几个方面:一、优先考虑归肺经中药,在应用不归肺经中药时要配伍归肺经中药;二、组方时应考虑含萜类、甾体及生物碱类化合物的中药;治疗肺咳病及咳嗽症状时可以考虑含萜类化合物的中药,治疗气喘症状时可以考虑含生物碱类化合物的中药;三、在确定组方中药或化学成分配伍关系时,君药多考虑含生物碱、黄酮类化合物的中药;臣药、佐药可以考虑含萜类及甾体类化合物中药;使药可以考虑含萜类、甾体类及黄酮类化合物的中药。

Results The typical manifestations of PCP was bilateral diffuse infiltration distributing in perihilar regions and presenting as radiate shadows from hila to lung fields.

结果 双肺弥漫性渗出性病变分布于肺门周围,而肺尖及周围肺野清晰,病灶由肺门向周围肺野发展且呈明显的融合趋势,为典型的影像学表现。

Methods: Twenty-four rabbits were randomly divided into three groups:① the control group(group C, n=8): received sternotomy only and no ischemia;② the ischemia/reperfusion group(group I/R, n=8): the left lungs of rabbits were rendered ischemia by ligating the left pulmonary hili for 60 minutes followed by 60 minutes reperfusion;③ the edaravone group(group E, n=8): the left lungs were rendered ischemia for 60 minutes followed by 60 minutes reperfusion, and 10 mg/kg edaravone was administered intravenously 5 minutes prior to ischemia. Blood MDA and SOD were measured. Protein concentrations, WBC count, and PMN percentage in broncho-alveolar lavage fluid were determined. Samples of left lung tissue were sent for determining the left lung dry-to-wet weight ratio and evaluating the pathologic changes.

采用兔肺原位热缺血再灌注损伤模型进行研究。24只大白兔随机分为三组:①对照组(C组, n=8),开胸后不阻断肺门,静脉缓慢推注生理盐水5ml/kg;②缺血再灌注组(I/R组, n=8),左肺接受60min的缺血,然后接受60min再灌注,于缺血前5min静脉缓慢推注生理盐水5ml/kg;③依达拉奉干预组(E组, n=8),于缺血前5min静脉缓慢推注依达拉奉10mg/kg(5ml/kg),左肺接受60min的缺血,然后接受60min再灌注。120min实验结束时,留取各组动物血液标本,测定血浆丙二醛含量及超氧化物歧化酶活性;收集支气管肺泡灌洗液,检测支气管肺泡灌洗液中白细胞计数、中性粒细胞百分比及肺通透性指数;留取肺组织标本,测定肺组织湿、干重量,计算干/湿重比及行肺组织病理检查。

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