肺癌

This study of polymorphism of human hereditary genes that associate with lung caner and alteration of related factor in lung cancer tissue will lay a foundation to reveal more secrets of lung cancer development.

我们研究人类先天遗传的、与肺癌相关的基因多态性及其相关因子在肺癌组织中的变化，将为揭开肺癌发生的奥秘提供有力依据。

9The sieve that scanning of 9mTc-MDP nuclide bone can check in installment as lung cancer checks the method; progress as lung cancer course of diseases, tumor labels the level of content CEA, CA125, NSE and CYFRA21-1 rises gradually. Other people of number of tumour of combination of 99mTc-MDP bone scanning has fundamental value in be not cellule lung cancer to be diagnosed in installment.

99mTc-MDP核素骨扫描可作为肺癌分期检查的筛查手段；随着肺癌病程的进展，肿瘤标记物CEA、CA125、NSE和CYFRA21-1的水平逐渐上升。99mTc-MDP骨扫描联合肿瘤标记物在非小细胞肺癌分期诊断中具有重要的价值。

Expressions of ChAT mRNA and protein were enhanced in 9 of the 18 lung tumor specimens; and expressions of ChoK mRNA and protein were increased in 14 of 18 lung tumor specimens compared with those of normal lung tissues. 8 of 18 lung cancer specimens were obvious increased in expressions of both ChoK and ChAT.

结果 18例肺癌的PET/CT图像均显示胆碱放射性摄取明显增高，18例肺癌组织细胞中，14例Chok mRNA及蛋白质的表达比正常肺组织升高，9例肺癌组织细胞ChAT mRNA及蛋白质表达升高，其中8例Chok及ChAT表达均升高。

We can use CT scan and GC system to establish the correlation between lung cancer patient and the marker VOCs in their exhaled breath. Detecting Benzene,Propyl benzene and Decane helps making diagnosis of lung cancer.

临床上应用颇成熟的CT检查对肺癌的检出其敏感性和特异性都较高，笔者通过CT检查和气相色谱系统的联用，探讨肺癌与肺癌患者呼吸气体中的特征性有机成分的对应关系。

Compared the VOCs in lung cancer patients and normal people and metabolic product of lung cancer cells to analyze the correlation between lung cancer and its marker VOCs.Results 7 lung cancer patients were detected three marker VOCs in their breath: Benzene,Propyl benzene and Decane.

在肺癌患者的呼吸气体中所含的特征性有机成分的检测方面［1～3］，已经有部分科研人员做了尝试，也有培养肺癌组织细胞并探测其代谢气体成分的研究［4］，期望能建立通过检测患者的呼吸气体即能够初筛肺癌患者的简便方法。

Five models were used to investigate the "Changdong"" s anti-tumor effect: mice S180 sarcoma solid model, mice liver cancer H22 solid model, mice Lewis lung cancer model, as well as human liver cancer QGY and colon cancer LOVO implanted in naked mice; mice liver cancer H22 was also used to evaluate the enhancive effect of "Changdong" when it was co-applied with other anti-tumor agent or with radiotherapy; The "Changdong"" s cytotoxic effect in vitro on such tumors as QGY, LOVO, lung cancer A549, breast cancer MCF-7, as well as mice leukemia P388 was observed through MTT method. And investigate the effect of "Changdong" on proliferation of spleen lymphocyte, on activity of NK cell and on synthesis of IL-2 in mice bearing Lewis lung cancer, respectively. With propidium iodide straining, cell aigptosis and cell circle were analyzed by flow cytometry. Result:"Changdong" has an evident tumor inhibitive effect on mice tumor model as well as human tumor implanted in naked mice with a quantity-effect relationship.

使用小鼠S180肉瘤、小鼠肝癌H22实体瘤和小鼠Lewis肺癌模型，以及人体肝癌QGY和人体肠癌LOVO裸鼠异种移植模型，进行"长动"的抗肿瘤药效学研究：用小鼠肝癌H22进行"长动"合并放疗和化疗的增效作用研究；用MTT法进行"长动"对肝癌QGY、肠癌LOVO、肺癌A549、乳腺癌MCF-7、小鼠白血病P388等10株人体和动物肿瘤细胞的体外细胞毒性作用研究；用淋巴细胞转化试验、小鼠NK细胞活性试验、小鼠胸腺细胞增殖法分别测定"长动"对荷Lewis肺癌小鼠的脾淋巴细胞增殖的影响、自然杀伤细胞活性的影响和对小鼠产生白介素-2(IL-2)的影响；用流式细胞仪PI单染色法进行"长动"对人体肝癌QGY细胞的体外诱导凋亡作用和对肿瘤细胞周期的影响的研究。

objective to investigate the reasons of misdiagnosis on the young patients with non-typical lung cancer,to enhancing the cognition of the disease.methods the data of incidence,clinical manifestation,imageology,bronchoscope,surgical pathologic examination of 32 cases with non-typical lung cancer were analyzed.results 8 cases of 32 patients were misdiagnosed as tuberculosis,7 cases were misdiagnosed as pneumonia,6 cases were misdiagnosed as tuberculosis pleurisy,3 cases were misdiagnosed as omarthritis,2 cases were misdiagnosed as arthritis,2 cases were misdiagnosed as transient ischemic attack,2 cases were misdiagnosed as hemicrania,2 cases were misdiagnosed as intervertebral disk hernia.conclusion the clinical symptom of young patients with non-typical lung cancer was non-typical,and the misdiagnosis rate was high.

目的 探讨不典型青年肺癌误诊的原因，以期提高对本病的认识。方法对32例误诊的青年肺癌(5岁)患者的发病情况、临床表现、影像学检查、支气管镜及手术病理检查进行分析。结果 32例患者中，误诊为肺结核8例，肺炎7例，结核性胸膜炎6例，肩周炎3例，关节炎2例，短暂性脑缺血发作2例，偏头痛2例，椎间盘突出2例。结论青年肺癌临床症状不典型，误诊率较高。

Results The PET/CT imaging was performed for 62 patients including 7 cases with central bronchial carcinoma, and 55 cases with peripheral lung cancer. 59 cases with confirmed diagnosis, the diagnostic accuracy rate was 95.16%. Some abnormal enrichment can be seen by 18F-FDG PET/CT. The largest SUV is 1.0～22.3. Radioactivity intussuscept can be seen by 11C-MET and PET-CT, and SUV is 0.5～4.9. Vessel bunch is available by CT enhancement scan that can clear the borderline of lession. Sublobe,spicule sign,depressed pleura,and bronchia obstruction can be seen by HRCT.

结果 62例肺癌患者中，中央型肺癌7例，周围型肺癌55例，明确诊断59例，诊断率95.16%。18F-FDG PET/CT检查见病灶有不同程度放射性异常浓聚，最大SUV1.0～22.3； 11C-MET PET/CT检查的病灶均见不同程度放射性摄取，SUV0.5～4.9；CT增强扫描病灶边界清晰，明显强化，可见血管"集束征"， HRCT检查见病灶有分叶、毛刺征、胸膜凹陷征及支气管阻断。

CT scanning can provide more information about peripheral pulmonary carcinoma than routine X-ray.The lobulation,spicules and pleural indentation around the mass suggest the diagnosis of pulmonary carcinoma.

CT诊断周围型肺癌比常规X线检查提供更多的信息；若CT发现肺部周围结节或肿块有分叶、毛刺及胸膜凹陷征等应考虑为肺癌，肺门、隆突下及纵隔淋巴结肿大且无钙化时，要考虑肺癌向淋巴结转移。

Tobacco smoke contains more than 60 carcinogens, among which polycyclic aromatic hydrocarbons and the tobacco-specific nitrosamine are likely to play major roles in lung carcinogenesis.

研究表明80%以上的肺癌可归咎于烟草暴露，而仅仅不到10%的吸烟者发展为肺癌，提示个体对于肺癌具有遗传易感性。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。