肺癌

Methods The BHD vector and the small interfer RNA targeting BHD was constructed and transfected into the cell line A549. The expression of BHD was examined by immunofluorescence. Transwell test was used to detect the invasion ability of A549 cells. Results After transfected BHD vector into A549 cells, immunofluorescence showed the expression of Folliculin located in cellular plasma.

制备BHD真核表达质粒，转染肺腺癌细胞，用免疫荧光法检测Folliculin蛋白在肺癌细胞中的表达位置；筛选sRNAi片段，选取有效抑制片段转入肺癌细胞，与转入BHD质粒的肺癌细胞对比，用Transwell实验了解BHD基因对肺癌细胞运动方面的影响。

The 1,3,5-year survival rates of regular lobectomy were higher than that segmentectomy and wedge resection.

按1997年国际抗癌联盟肺癌分期标准，肺癌各个期别间的5年生存率差异有统计学意义[2]，其中Ⅰ期肺癌的诊断与治疗在整个肺癌治疗策略中尤为重要。

Abstract］ objective to study the knowledge of the imaging manifestation of x-ray and ct in peripheral small lung cancer.methods to collect twenty cases with no symptom in early time diagnosed by clinic and to retrospectively analyze their imaging features.results x-ray appeared patch,small node.ct appeared patch,small node,light lobulation,peripheral vessel convergence,pleural indentation sign.most of the diameter was 1.5 to 2 cm,with no mediastinum and pulmonary hilar lymph nodes diversion.furthermore the clinical symptom was not obviously.conclusion to be familiar and handling the sign mentioned above is the key to boost the diagnosis of small peripheral lung cancer.

目的 探讨周围型小肺癌的x线、ct影像学表现。方法收集临床和病理证实的早期无症状肺癌20例，对其影像学进行回顾分析。结果本组早期肺癌x线为斑片状、小结节状。ct表现为斑片状、小结节状、轻度分叶状肿块，小毛刺、血管集束征、胸膜凹陷征，大多直径在1.5～2 cm。无纵隔淋巴及肺门转移，且临床症状不明显。结论熟悉并掌握上述征象是提高小肺癌早期诊断率的关键。

Results Compared high kV X-ray chest film with spiral CT,to simplex silicosis,X-ray films coincided with CT scans;to mixed silicosis,the effect of CT scans were better than X-ray's;to large nodule,coalesced progressive massive fibrosis,the detected ratio of CT scans were higher than X-ray chest films;to silicosis complication,for example,emphysema,pleural thickening,phthisic,mediastinal impairment lympy node etc,CT scans were more reliable than X-ray films,especially HRCT can earlier find silicotic nodule and fine structure of focus.Selective application of CT scan,had great diagnostic value in complicated silicosis and silco-tuberculosis and lung cancer complicated with silicosis etc.

结果 高千伏X线胸片与螺旋CT作对比，结果对单纯矽肺并发肺癌，CT片与X线胸片基本一致；对于复杂矽肺并发肺癌CT优于X线胸片；对于大结节、肺内进行性大块纤维化(progressive massive fibrosis，PMF)融合、空洞及钙化CT检出率明显高出胸片；对矽肺并发肺癌的合并其他如肺气肿、胸膜肥厚、结核、纵隔淋巴受累等CT均较胸片可靠；特别是HRCT能早期发现矽肺肿块样病灶中细微结构，选择性应用CT，对复杂矽肺并发肺癌合并结核等鉴别诊断有很大价值。

Results: 15 cases of nodule-type underpleura lung cancer were provided with representative CT appearance. The mainly CT appearance of 23 cases consolidation-type underpleura lung cancer were consolidation under pleura, pleural change, fibre gathering and emphysematous spaces.

结果：15例结节型临近胸膜周围型肺癌具有典型的周围型肺癌的CT表现，23例实变型临近胸膜周围型肺癌以临近胸膜实变影、胸膜改变、纤维条索聚集及肺大泡为主要CT征象，5例渗出型临近胸膜周围型肺癌表现为炎症CT征象。

In the current study, we have detected the mtDNA mutation in lung cancer, investigated the correlation between the mtDNA mutations and carcinogenesis, and explored the possibility of mtDNA mutations as a biomarker. We also analyzed the reasons for the homoplasmic mutations of mtDNA.

为了探讨mtDNA突变在肺癌发生中的意义、mtDNA突变在肺癌早期诊断中作为分子标记的可能性以及mtDNA多态性与肺癌易感性的关系，我们检测了肺癌mtDNA突变，分析了肿瘤中mtDNA同质性突变的形成原因。

Results showed that the CT expressions as:① 3 big cavity and peripheral pleated shadow;②60 parenchymatous degeneration of pulmonary segments in lobes of lung, atele...

表明原发性肺癌不典型CT表现与肺癌的类型有关；与肺癌本身的生长方式有关；与合并结核病有关；与肺癌的恶性程度及胸膜胸壁转移有关。

Objective Pulmonic carcinoma is the most common thoracic cancer,including small cell lung cancerand non-small cell lung cancer.

目的肺癌为胸外科常见恶性肿瘤，可分为小细胞肺癌与非小细胞肺癌；目前肺癌的发病机理尚未纯粹明了，肺癌的早期诊断、治疗效果均较差。

There is not a significant difference in these groups by one-way analysis of variance. 2 Among 51 cases with lung cancer, 7 specimens showed malignant cells in bronchial lavages, including 4 cases in central lung cancer and 3 cases in peripheral lung cancer. Concordant results were observed in 20 cases. 6 specimens showed malignant cells on cytological analysis, and NMSP was positive in at least one gene tested. 14 samples did not show malignant cells on cytological analysis, and the NMSP results were correspondingly negative. The results of cytology and NMSP were discordant in 31 samples. 30 samples were cytologically negative, but NMSP positive in one or more genes. In addition, there was one case that the cytology was positive for malignant cells, but the NMSP was negative in all of the three gene tested.

51例肺癌患者支气管灌洗液细胞学检查发现肺癌细胞7例，其中27例中心型肺癌患者4例支气管灌洗液发现肺癌细胞，24例周围型肺癌患者3例支气管灌洗液发现肺癌细胞。20例支气管灌洗液细胞学检查和过甲基化检测得到一致结论。6例支气管灌洗液发现肿瘤细胞，过甲基化分析至少一个基因阳性。14例灌洗液未发现肿瘤细胞，三个基因过甲基化分析均为阴性。31例支气管灌洗液细胞学检查和过甲基化检测得到不一致结论，30例细胞学检查为阴性，但过甲基化分析一个或一个以上基因为阳性。1例细胞学检查阳性但过甲基化分析阴性。

We extracted DNA from bronchial lavages cells and supernatants, and made a quantitative analysis of free DNA from supernatants, then analyzed hypermethylation of three genes in bronchial lavages supernatants and cells. Our objective is to investigate the possibility of bronchial lavages supernatants used in molecular biology diagnosis of lung cancer, and the value of hypermethylation of gene in the diagnosis of primary lung cancer.

本研究选取北京胸部肿瘤结核病医院收治怀疑肺癌患者78例，包括肺癌51例，其中鳞癌23例，腺癌20例，小细胞癌5例，腺鳞癌3例，中心型肺癌27例，周围型肺癌24例，男性32例，女性19例，平均年龄(57.1±13.5)岁，良性病变患者27例，其中肺结核17例，肺炎5例，肺部良性肿瘤5例，男性16例，女性11例，平均年龄(39.5±10.7)岁。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。