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RESULTS: The expression of VCAM1 in the lung tissues of normal rats was weak, and distributed mainly in alveolar epithelial cells, bronchiole epithelial cells, alveolar macrophage and some pulmonary interstitium.

结果: 在正常对照组,VCAM1大鼠肺组织中呈弱表达,分布于肺泡上皮细胞、细支气管上皮细胞、肺泡巨噬细胞及少量的肺内间质。

After repeffusion alveolar capillaries were engorge, miM infiltration of the inflammatory cells and minimal interstitial edematous was seen in the perivascular.

仅12、18和24h组可见灶状肺泡萎陷;缺血-再灌注组的肺小动脉及血管内充血,部分肺泡壁血管充血伴周围炎性细胞渗出。

The superficial microvascular networks were sparser, while the subpleural microvascular networks were denser. The superficial blood vessels and the interlobular blood vessels were mutual transitional, and the anastomosing between the superficial blood vessels with the subpleural vessels. According to the branching sequence of the subpleural arteriole, it could be divided into the arteriole, terminal arteriole, precapillary arteriole and capillary in turn. The subpleural capillary networks were mainly web-like, while small holes were also found on the cast. The honeycomb vascular networks were various in size and form at a low magnification. The outline of alveolus, alveolar sac, alveolar duct and respiratory bronchiole and terminal bronchiole, made of microvascular networks, could be found in the cut surface.

胸膜面浅层的微血管网稀疏,深层的胸膜下微血管网致密;胸膜面浅层的微血管与小叶间隔的微血管之间相互移行,与胸膜下微血管之间形成吻合连接;根据胸膜下微动脉连续分支的顺序,常可将其分为微动脉、终末微动脉、毛细血管前微动脉和毛细血管四级;胸膜下毛细血管网主要以网络状的形式存在,但在铸型上均可见数量不等的"小孔状"结构;低倍镜下肺实质内微血管网呈现大小不等、形态各异的蜂窝状结构,可以见到由微血管网构成了肺泡、肺泡囊、肺泡管和呼吸性细支气管以及终末细支气管等结构的轮廓。

The anastomosing occurred between the pleural superficial and the subpleural vascular networks on the capillary level or the precapillary level. The honeycomb vascular networks were also various in size and form at a low magnification. The venule connected with the pulmonary capillary networks directly at a high magnification. The single capillary networks were found in the alveolar septa. The longitudinal crests and dense round imprints of endothelial nuclei and the clear circular constrictions were found on the surface of the larger vessel in the lung parenchyma. The round imprints of endothelial nuclei also occurred on the subpleural venule and capillary.

胸膜面浅层的微血管与胸膜下微血管之间形成毛细血管水平或毛细血管前水平的吻合;低倍镜下肺实质内微血管网也呈现大小不等、形态各异的蜂窝状结构;高倍镜下肺泡毛细血管与微静脉之间联系紧密;在肺泡隔内毛细血管网成单层分布;肺实质内管径较大的微血管表面可以见到纵行的嵴状结构和密集的内皮细胞核的压痕,以及明显的环形缩窄;胸膜下微静脉和毛细血管表面可见圆形内皮细胞核的压痕。

The experimental group has various changes in the different density of potentill anserine extract.

实验组不同浓度的蕨麻提取物对小鼠肺组织的影响不同,Ⅰ组小鼠肺组织表面肉眼见不同程度的散在点状出血、显微镜下肺泡腔内见散在红细胞;Ⅱ组小鼠肺组织表面肉眼无明显异常,显微镜下肺泡腔内见散在红细胞及淡伊红色液体,两组均见肺泡壁毛细血管扩张充血及毛细血管内皮细胞呈不同程度的增生肥大。

The experimental group has various changes in the different density of potentill anserine extract. The small rat pulmonary tissue surface ofⅠgroup can see sporadic petechia of different degree; pulmonary alveolus cavity can see sporadic erythrocyte under the microscope. The small rat pulmonary tissue surface of Ⅱ group is no obvious abnormality by naked eye; pulmonary alveolus cavity can see sporadic erythrocyte and thin powder color liquid under the microscope. Two groups all have the capillary vessel of alveolar wall dilation and the endothelial cell hyperplasia and hypertrophy in different degree.

实验组不同浓度的蕨麻提取物对小鼠肺组织的影响不同,Ⅰ组小鼠肺组织表面肉眼见不同程度的散在点状出血、显微镜下肺泡腔内见散在红细胞;Ⅱ组小鼠肺组织表面肉眼无明显异常,显微镜下肺泡腔内见散在红细胞及淡伊红色液体,两组均见肺泡壁毛细血管扩张充血及毛细血管内皮细胞呈不同程度的增生肥。

The experimental group has various changes in the different density of potentill anserine extract. The small rat pulmonary tissue surface ofⅠgroup can see sporadic petechia of different degree; pulmonary alveolus cavity can see sporadic erythrocyte under the microscope.

实验组不同浓度的蕨麻提取物对小鼠肺组织的影响不同,Ⅰ组小鼠肺组织表面肉眼见不同程度的散在点状出血、显微镜下肺泡腔内见散在红细胞;Ⅱ组小鼠肺组织表面肉眼无明显异常,显微镜下肺泡腔内见散在红细胞及淡伊红色液体,两组均见肺泡壁毛细血管扩张充血及毛细血管内皮细胞呈不同程度的增生肥大。

The experimental group has various changes in the different density of potentill anserine extract. The small rat pulmonary tissue surface ofⅠgroup can see sporadic petechia of different degree; pulmonary alveolus cavity can see sporadic erythrocyte under the microscope. The small rat pulmonary tissue surface of Ⅱ group is no obvious abnormality by naked eye; pulmonary alveolus cavity can see sporadic erythrocyte and thin powder color liquid under the microscope. Two groups all have the capillary vessel of alveolar wall dilation and the endothelial cell hyperplasia and hypertrophy in different degree.

实验组不同浓度的蕨麻提取物对小鼠肺组织的影响不同,Ⅰ组小鼠肺组织表面肉眼见不同程度的散在点状出血、显微镜下肺泡腔内见散在红细胞;Ⅱ组小鼠肺组织表面肉眼无明显异常,显微镜下肺泡腔内见散在红细胞及淡伊红色液体,两组均见肺泡壁毛细血管扩张充血及毛细血管内皮细胞呈不同程度的增生肥大。

Acute diffuse lung injury were identified in toxication control group, intra-pul

结果 中毒组大鼠肺的病理学改变为急性弥漫性肺损伤,表现为肺泡腔内出血、渗出、炎性细胞浸润,肺泡隔炎性细胞浸润及纤维组织增生,⌒秃廷⑿蜕掀は赴坏死脱落。

The experimental group has various changes in the different density of potentill anserine extract. the small rat pulmonary tissue surface ofⅰgroup can see sporadic petechia of different degree; pulmonary alveolus cavity can see sporadic erythrocyte under the microscope. the small rat pulmonary tissue surface of ⅱ group is no obvious abnormality by naked eye; pulmonary alveolus cavity can see sporadic erythrocyte and thin powder color liquid under the microscope.

实验组不同浓度的蕨麻提取物对小鼠肺组织的影响不同,ⅰ组小鼠肺组织表面肉眼见不同程度的散在点状出血、显微镜下肺泡腔内见散在红细胞;ⅱ组小鼠肺组织表面肉眼无明显异常,显微镜下肺泡腔内见散在红细胞及淡伊红色液体,两组均见肺泡壁毛细血管扩张充血及毛细血管内皮细胞呈不同程度的增生肥大。

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