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Results AQP1 is expressed at the apical and basolateral membrane of the microvascular endothelium; AQP3 was detected at basal cells of both the bronchiole epithelium and submucosal gland acinus; AQP4 is present in the basolateral membrane of columnar cells in bronchiole; while AQP5 is expressed in the apical membrane of type Ⅰ pneumocytes, and also at the apical of columnar cells of superficial epithelium and submucosal gland acinar cells.

结果本研究发现AQPs基因在羊肺中的表达分布与人相似,AQP1在肺内的毛细血管内皮细胞表达;AQP3在小支气管黏膜上皮的基底细胞的基侧膜表达,AQP4存在于小支气管黏膜上皮的柱状纤毛细胞的基侧膜;AQP5存在于Ⅰ型肺泡上皮细胞的顶质膜,存在于小支气管黏膜上皮柱状纤毛细胞,以及在气道黏膜下腺的腺细胞的顶质膜表达。

Between P14 and P21,CIAPIN1 immunoreaction in the brain,heart and liverbecame much lower. However,between P21 and P28,CIAPIN1 immunoreactionin the heart,brain,liver and skeletal muscle became much lower,while with thekidney development,CIAPIN1 immunoreaction in the kidney became higher. Invarious tissues from adult mouse,CIAPIN1 immunoreaction could be seen incardiac muscle cell,brain,hepatocyte,epithelium of renal tubule,skeletal muscle,lung tissue,gastric mucosa and gland,acinus lienalis.2. Distribution of CIAPIN1 in normal fetal and adult human tissuesTo reveal the possible physiological role of CIAPIN1,we examined theexpression and distribution of CIAPIN1 in fetal and adult human tissues usingimmunohistochemistry. We found that CIAPIN1 was ubiquitously distributed infetal and adult tissues,and was localized in both the cytoplasm and the nucleus.

然而,在3个月大的成年鼠中,CIAPIN1阳性反应物在心、脑、肝和肾小管中的表达强度要低于P28小鼠;但CIAPIN1阳性反应物在成年鼠骨骼肌中较P28小鼠高。2、CIAPIN1蛋白在人5个月胚胎及成人多器官组织内的表达在人5月胚胎多器官组织中,CIAPIN1阳性反应物见于心脏、胆囊单层柱状上皮和粘膜、结肠粘膜、小肠粘膜和绒毛、肝脏、直肠腺体、胃粘膜、肾上腺束状带、甲状腺滤泡、脾索、胸腺小叶间隔、皮肤真皮层和汗腺、睾丸白膜和间质、脑组织内神经元和神经胶质、肺小支气管和肺泡、骨骼肌、肾脏皮髓质和肾小管、子宫内膜、胰腺腺泡和胰岛、卵巢、输卵管粘膜等绝大多数组织细胞。

Pulmonary alveolus: Any of the 300 million or so small air spaces in the lung s where carbon dioxide leaves the blood and oxygen enters it.

肺泡:肺内的约3亿个小气囊,于此,二氧化碳从血中排出,氧气进入血液。

Surfactant is produced by alveolar type II cells, stored intracellularly in organelles known as lamellar bodies, and secreted by exocytosis.

肺表面活性物质由肺泡Ⅱ型细胞生成,储存于细胞内的一些细胞器中,由胞外排泌形式分泌。

Expressed as a fraction ofthe minimum alveolar anesthetic concentration preventingmovement in 50% of rats, the amnestic 50% effective dose (ED50)for fear to tone in control rats inhaling isoflurane and injectedwith saline intraperitoneally i.p.

用能防止50%大鼠动反应的最小肺泡浓度的一个分数来表示的遗忘音调恐惧的50%有效剂量( ED50),在吸入异氟醚且腹膜内

Results 6 patients with PAP presented with ground-glass opacification of the bilateral lungs on HRCT. Typical chest HRCT scan showed "map-like" lesions in 3 cases and "cobble stone-like" lesions in 3 cases. Multifocal consolidative opacities in the lungs were seen on HRCT in 3 cases. Lung biopsies from 6 patients with PAP revealed a prominent positive periodic acid-Schiff intra-alveolar exudates. There were normal alveolar spetasis in 3 patients while interstitial thickening, fibroblast hyperplasia, interstitial fibrosis in the others.

结果 6例患者在不同层面可见磨玻璃影,其中2例可见小结节影;3例表现为两肺斑片状磨玻璃影与周围肺组织分界清楚,呈地图样改变;3例因磨玻璃影与小叶间隔增厚交织成铺路石样改变;3例可见肺泡实变融合成密度较高的斑片状阴影,1例在肺泡实变区可见&空气支气管征&。6例患者活检肺组织在光镜下显示肺泡腔内充满大量块状或颗粒状嗜伊红物质,PAS染色阳性,AB染色阴性,其中3例肺泡间隔正常,3例肺泡间隔增宽,可见慢性炎性细胞浸润、成纤维细胞增生和胶原沉积。

At high magnification, the alveoli in this lung are filled with a smooth to slightly floccular pink material characteristic for pulmonary edema.

高倍镜显示,肺泡内充满表面光滑并且泡沫状粉红色物质,这是肺水肿的特征。

A cleft or infolding of the visceral pleura will form if the rate of pleural fluid formation exceeds that of alveolar air absorption.

如果胸膜渗液形成的速度超过肺泡吸收的速度,在脏层胸膜将形成裂隙或内折。

A cleft or infolding of the isceral pleura will form if the rate of pleural fluid formation exceeds that of aleolar air absorption.

如果胸膜渗液形成的速度超过肺泡吸收的速度,在脏层胸膜将形成裂隙或内折。

The time courses of intra-alveolar cells,protein, albumin, IL-8, elastase, and IL-10 did not differ betweenthe groups after OLV and postoperatively.

单肺通气后和术后肺泡内细胞、蛋白质、球蛋白、 IL-8、弹性蛋白酶和 IL-10的时间过程在两组间没有差异。

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