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Objective To investigate the pulmonary vasodilator effect of adenosine triphosphate infused into pulmonary artery on pediatric pulmonary hypertension after open heart surgery.

目的探讨经肺动脉输注三磷酸腺苷(adenosinetriphosphate,ATP)对心脏术后合并肺动脉高压患儿的肺血管扩张效应。

Objective To evaluate the efficacy of cardioangiography on diagnosis of pulmonary atresia with ventricular septal defect and coronary artery fistula.

目的探讨心血管造影对肺血主要来源于冠状动脉肺动脉瘘的肺动脉闭锁合并室间隔缺损的诊断价值。

Results: Thrombus within right ventricle and main pulmonary artery was detected in 6 patients, right atrium and RV enlargement was found in 19 patients, right ventricular hypokinesis was found in 21 patients, hypokinesis of interventricular septum was detected in 13 patients, MPA and right pulmonary arterial dilation was found in 22 patients, marked tricuspid regurgitation was detected in 23 patients, pulmonary hypertension was found in 23 patients.

右心异常改变者26例(包括超声直接检出血栓的6例),其中右房室增大19例;右室收缩功能减退21例;室间隔左移、左室短轴切面室间隔向左室膨突呈&D&型改变1例;室间隔运动幅度减低13例;主肺动脉及右肺动脉增宽22例;三尖瓣中量以上返流23例;肺动脉收缩压增高23例,范围在33~81mmHg (62.87±23.46 mmHg),治疗后肺动脉压明显下降,范围在21~52 mmHg (34.26±13.52 mmHg)。

3 Can partially prevent excess collagen deposition in pulmonary arteries, attenuate hypoxia and MCT-induced pulmonary hypertension and reduce the percentage of nonmuscular intra-acinar arteries.

但对缺氧性肺动脉高压肺动脉壁胶原的抑制以及逆转右室肥厚的作用弱于BAPN.3.764-3很可能通过逆转中膜平滑肌细胞表型的改变而抑制肺动脉壁胶原的过度沉积。4。

Chronic hypoxia and MCT-induced pulmonary hypertension are associated with excess collagen deposition in pulmonary arteries; meanwhile, the muscularization of nonmuscular intra-aeinar arteries also plays an important role in maintenance of pulmonary hypertension.

1。在慢性缺氧和MCT诱发的肺动脉高压进展过程中,肺动脉壁胶原沉积过度,泡内动脉结构发生改变,动脉中层厚化,非肌性动脉肌性化。2.764-3能部分抑制胶原的过度沉积,降低缺氧性及野百合碱性肺动脉高压,从而逆转泡内动脉的结构改变。

METHODS: Twentyfour patients with congenital heart defects were divided into 3 groups: mild pulmonary hypertension group(n=8), moderate or severe pulmonary hypertension group(n=9), and nonpulmonary hypertension group(n=7). NOS mRNA expression was detected in lung tissues with reverse transcriptase polymerase chain reaction.

将24例左向右分流先天性心脏病患者分为三组:轻度肺动脉高压8例,中重度肺动脉高压9例和无肺动脉高压7例,应用逆转录多聚酶链式反应检测患者肺组织中NOS mRNA的表达。

Results Both inhibitions of PKC with 6.8 mmolL^(-1) hypericin and PKA with 0.112 mmolL^(-1) KT5720 shifted the dose-response curve of 15-HETE induced pulmonary vasoconstriction to the right, and more powerful inhibition was observed with PKC inhibitor (P.01). Denuding endothelia decreased the response of PA ring to 15-HETE in both normoxic and hypoxic PA rings (P.05, P.01, respectively).

结果 用6.8 mmolL^(-1) hypericin阻断PKC途径可使15-HETE收缩缺氧大鼠肺动脉量效曲线右移(P.01);用0.112 mmolL^(-1) KT5720阻断PKA途径使15-HETE收缩缺氧大鼠肺动脉量效曲线右移不明显;除去血管内皮细胞可降低对照组和缺氧组肺动脉血管环对15-HETE的反应性。

Skeletal muscle ventricle constructed from conditioned skeletal*muscles, lined with autogenous or bovine pericardium, and connected with valved homografts between right atrium or venae cava and main pulmonary artery, has been demonstrated to be nonthrombogenic.

经耐疲劳训练的自体骨骼肌,内衬自体心包制成骨骼肌心室,并以同种带瓣主动脉吻合于右心房或上、下腔静脉与肺动脉之间来代替或辅助右心室的功能,可提高肺动脉收缩压及肺动脉血流并使之成为波动性,而且具有不需抗凝,无血栓形成等优点。

Results The degree of pulmo nary stenosis is preperation to pulmonary flow velocity.

结果肺动脉瓣狭窄程度与肺动脉内血流速度成正比例关系,对照手术前后肺动脉内血流速度,可估价手术效果。

Results:(1) The PAP of BLM and liposome groups was higher than that of control and trans-gene groups.

结果:①肺动脉压力:BLM组及脂质体组肺动脉压力明显增高,转基因组肺动脉压力明显低於BLM组及脂质体组。

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