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A pulmonary acinus is defined as that portion of lung distal to the terminal bronchiole, and up to 12 acini can make up one secondary pulmonary lobule.

腺泡是指终末支气管远端的部分,12个腺泡组成一个次级小叶。

We further evaluated the synergistic cytotoxicity of TRAIL in combination with actinomycin D, cisplatin and paclitaxel in A549 cell lines in vitro and in vivo.

本实验选择了人腺癌A549细胞瘤株作为我们实验研究的对象,通过TRAIL对人腺癌A549细胞诱导凋亡研究,在A549的荷瘤裸鼠的动物模型上研究了其体内的抗肿瘤活性,并进一步研究了TRAIL与化疗药物放线菌素D(actinomycin D,Act D)、紫杉醇和顺铂(cisplatin,CDDP)的联合作用对人腺癌A549细胞的体外协同抗肿瘤活性,通过化疗药物协同增强TRAIL抗肿瘤活性作用机制的初步研究,为降低临床化疗药的用药量,减轻其对机体的不良反应提供一定的理论基础。

In this experimental conditions, the VEC had not damnified obviously by perfusion with IECS in 4 hours. The pulmonary vascular resistance could decreased by POE1 and so vascular endolhelial cells would be protected. Mannitol not only increase osmotic pressure but also cleanse OFR. The addition of mannitol, POE1, glucose and osmotic pressure to IEC solution contributes to reduce the quantities of OFR.

2在本实验条件下所采用的IECS进行犬灌洗、离体保存4h之内血管内皮细胞无明显损伤,PGE;具有保护血管内皮细胞的作用;甘露醇具有增加渗透压和清除自由基的作用;灌洗前动脉内注射PGE;及增加 ECS渗透压和代谢底物、提高PH值使之略微偏碱均有助于抑制供体离体、低温、冷缺血保存期间OFR的产生。

Methods The chest of the confirmed diagnosis of 101 cases of silicosis and 6 objects of observation were radiographed by the CR high thousand voltageand and the tradition high thousand voltage. Refereing to Diagnostic Criteria of Pnemoconioses and 23 chest standard films, we evaluated every radiograph quality and divided the period of silicosis at random.

将已确诊的101例尘埃沉着症患者和6例O+患者,采用CR高千伏和传统高千伏两种方法,各摄胸部正位片1张,由尘埃沉着症诊断小组,按照尘埃沉着症病诊断标准(GBZ 70-2002)及23张标准片,随机对每张胸片质量和尘埃沉着症诊断及其分期进行评定。

A total of 60 male Sprague-Dawley rats were randomly divided two groups, each group was further subdivided into sham, control, SS group (n=6, per subgroup), animas were sacrificed at different reperfusion periods of 2 h and 24 h, respectively. Oxygenation indexes, lung injury scores, wet/dry ratio, myeloperoxidase activity, Malondialdehyde and cytokine-induced neutrophil chemotactic factor in the transplanted lung and serum were measured.

雄性SD大鼠60只,随机分2组,每组又分3个亚组(n=6):假手术组、0.9%氯化钠液对照组、西维来司钠组,分别在冷缺血4 h后再灌注2 h和24 h收集标本,测量移植氧合指数(PO2/FiO2)、损伤病理评分、移植湿干重比、髓过氧化物酶活性(MPO、组织和血清中丙二醛、细胞因子诱导的中性粒细胞趋化因子。

Histologic analyses showed intra-alveolar edema, capillary hyperemia and neutrophil accumulated in the control group, whereas no significant changes in the lung protective group.

组织活检病理检查结果,对照组组织可见中性粒细胞浸润、间质水肿、泡壁小血管扩张、充血;保护组组织病理改变较轻微。

The oxygen index was higher in the lung protect group than that of in the control group at 0, 6, 12 and 24 h after CPB (P.05). In both groups, compared with the baseline values, plasma levels of MDA, IL-6 and TNF-α were gradually increased after CPB. Compared to the control group, the level of MDA, IL-6 and TNF-α were lower in the protective group at different time point after CPB (P.01). Histologic analyses showed intra-alveolar edema, capillary hyperemia and neutrophil accumulated in the control group, whereas no significant changes in the protective group.

结果 保护组各时点血氧指数均高于对照组(P.05),CPB后血浆MDA、IL-6和TNF-α水平较术前升高(P.05);在CPB后各时间点,保护组患者血浆IL-6、TNF-α和MDA均低于对照组(P.05);对照组组织可见中性粒细胞浸润、间质水肿、泡壁小血管扩张、充血,保护组组织炎性反应较轻微。

These animals were killed after 24 hours of treatments and instillation of meconiums. The measurements included lung tissue wet/dry ratio,lung injury score,the expression and level of AngⅡ,lung myeoperoxidase activity and TNF-α level.

模型制备后24h取材,观察其组织病理损伤并检测湿/干重比及进行病理评分;检测AngⅡ在组织的表达情况及用图像分析方法检测其含量;测定组织中肿瘤坏死因子-α的含量及匀浆髓过氧化物酶活性。

Results:Compared with the normal controls, manifestations of severe right heart failure,well-elevated pulmonary arterial pressure and serious right heart hypertrophywere observed in the pulmonary hypertensive rats 28 days after left lungresection and MCT injection.

结果:与对照组相比,MCT 注射后28 天大鼠出现重度右心衰竭征象,平均动脉压、右室肥厚度均明显升高;镜下可见明显血管重构,表现为右纤维化、小动脉内皮和中膜平滑肌层增生、血管密度降低;组织中HGF、eNOS 表达明显减少、TGF-β和ET-1 显著升高(P0.05),这些细胞因子表达量的改变与血管重构存在着明显的相关性。

The morphologic changes were observed with microscopy. It was observed that the values of NOS, MPO, MDA of the muscle and lung in LIR group increased significantly and the content of PC decreased obviously compared with those of the normal control.

结果显示,与对照组比较,LIR组骨骼肌和组织NOS活性均增强,MDA值、MPO活性增加,W/D值增大,PC含量降低;光镜下,间质多形核粒细胞聚集和浸润,间隔面密度值增加。

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